U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

env envelope protein [ Simian immunodeficiency virus ]

Gene ID: 1490007, updated on 18-May-2019

Summary

Go to the top of the page Help
Gene symbol
env
Gene description
envelope protein
Locus tag
SIVgp6
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Simian immunodeficiency virus (isolate: 677, nat-host: Cercopithecus aethiops (African green monkey))
Lineage
Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; Lentivirus; Primate lentivirus group
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
clone: gri-1
Sequence:
NC_001549.1 (6202..8766)

NC_001549.1Genomic Context describing neighboring genes Neighboring gene Gag-Pol;gag protein Neighboring gene vif protein Neighboring gene vpx protein Neighboring gene Neighboring gene Neighboring gene nef protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001549.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Signatures in Simian Immunodeficiency Virus SIVsmE660 Envelope gp120 Are Associated with Mucosal Transmission but Not Vaccination Breakthrough in Rhesus Macaques. Smith SA, et al. J Virol, 2016 Feb 15. PMID 26676777, Free PMC Article
  2. Systematic analysis of intracellular trafficking motifs located within the cytoplasmic domain of simian immunodeficiency virus glycoprotein gp41. Postler TS, et al. PLoS One, 2014. PMID 25479017, Free PMC Article
  3. Loss of a conserved N-linked glycosylation site in the simian immunodeficiency virus envelope glycoprotein V2 region enhances macrophage tropism by increasing CD4-independent cell-to-cell transmission. Yen PJ, et al. J Virol, 2014 May. PMID 24554659, Free PMC Article
  4. A single amino acid mutation in the envelope cytoplasmic tail restores the ability of an attenuated simian immunodeficiency virus mutant to deplete mucosal CD4+ T cells. Breed MW, et al. J Virol, 2013 Dec. PMID 24027336, Free PMC Article
  5. An AUG codon upstream of rev and env open reading frames ensures optimal translation of the simian immunodeficiency virus Env protein. van der Velden GJ, et al. Virology, 2013 Feb 5. PMID 23260111

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Here, the authors show that this conserved hydrophobic patch (amino acid residues 307, 309 and 317) contributes to gp120-trimer association in HIV-1 subtype C, HIV-2 and SIV.
    Title: Contribution of the gp120 V3 loop to envelope glycoprotein trimer stability in primate immunodeficiency viruses.
  2. Residues at gp120 positions 23, 45, 47, and 70 (Ile-Ala-Lys-Asn [I-A-K-N]) emerged as signatures of mucosal transmission.
    Title: Signatures in Simian Immunodeficiency Virus SIVsmE660 Envelope gp120 Are Associated with Mucosal Transmission but Not Vaccination Breakthrough in Rhesus Macaques.
  3. 12 potential intracellular-trafficking motifs (YXXPhi or LL/LI/IL) in the SIV gp41 cytoplasmic domain
    Title: Systematic analysis of intracellular trafficking motifs located within the cytoplasmic domain of simian immunodeficiency virus glycoprotein gp41.
  4. Env internalization protects human and simian immunodeficiency virus-infected cells from antibody-dependent cell-mediated cytotoxicity.
    Title: Envelope Glycoprotein Internalization Protects Human and Simian Immunodeficiency Virus-Infected Cells from Antibody-Dependent Cell-Mediated Cytotoxicity.
  5. These findings suggest that the loss of the N173 N-linked glycosylation site increases SIVmac239 replication in macrophages by enhancing CD4-independent cell-to-cell virus transmission through CCR5-mediated fusion.
    Title: Loss of a conserved N-linked glycosylation site in the simian immunodeficiency virus envelope glycoprotein V2 region enhances macrophage tropism by increasing CD4-independent cell-to-cell transmission.
  6. GYxxO motif and S727P each contribute to SIV's ability to deplete mucosal CD4+ T cells.
    Title: A single amino acid mutation in the envelope cytoplasmic tail restores the ability of an attenuated simian immunodeficiency virus mutant to deplete mucosal CD4+ T cells.
  7. The absence of CD4 T cells results in failure to produce antibodies that neutralize CD4-independent Envs and CD4-pretriggered control Envs.
    Title: CD4+ T cells support production of simian immunodeficiency virus Env antibodies that enforce CD4-dependent entry and shape tropism in vivo.
  8. study investigated the mechanism by which SIV regulates Rev and Env protein; SIV has evolved to allow maximal Env protein translation, despite the fact that its ORF represents the third ORF on the dedicated Env mRNA
    Title: An AUG codon upstream of rev and env open reading frames ensures optimal translation of the simian immunodeficiency virus Env protein.
  9. These findings indicate that disruption of this trafficking motif by the DeltaGY mutation leads to a striking alteration in anatomic distribution of virus with sparing of lamina propria and a lack of microbial translocation.
    Title: Loss of a tyrosine-dependent trafficking motif in the simian immunodeficiency virus envelope cytoplasmic tail spares mucosal CD4 cells but does not prevent disease progression.
  10. Upstream AUG codons in the simian immunodeficiency virus SIVmac239 genome regulate Rev and Env protein translation
    Title: Upstream AUG codons in the simian immunodeficiency virus SIVmac239 genome regulate Rev and Env protein translation.
Submit: New GeneRIF Correction See all GeneRIFs (23)

General gene information

Go to the top of the page Help

Homology

General protein information

Go to the top of the page Help
Preferred Names
envelope protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001549.1 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_054372.1 envelope protein [Simian immunodeficiency virus]

    See identical proteins and their annotated locations for NP_054372.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q02837
    Conserved Domains (2) summary
    cd09909
    Location:549 → 669
    HIV-1-like_HR1-HR2; heptad repeat 1-heptad repeat 2 region (ectodomain) of the gp41 subunit of human immunodeficiency virus (HIV-1), and related domains
    pfam00516
    Location:22 → 522
    GP120; Envelope glycoprotein GP120
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.