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Gzma granzyme A [ Mus musculus (house mouse) ]

Gene ID: 14938, updated on 7-Jun-2021

Summary

Official Symbol
Gzmaprovided by MGI
Official Full Name
granzyme Aprovided by MGI
Primary source
MGI:MGI:109266
See related
Ensembl:ENSMUSG00000023132
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hf; SE; TS; Ctl; Hf1; SE1; TSP; Ctla; TSP1; Ctla3; TSP-1; Ctla-3; AW494114
Expression
Biased expression in large intestine adult (RPKM 10.7), thymus adult (RPKM 4.7) and 9 other tissues See more
Orthologs
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Genomic context

See Gzma in Genome Data Viewer
Location:
13 D2.2; 13 63.93 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (113230358..113237515, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (113093824..113100981, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (113884035..113891189, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene cell division cycle 20B Neighboring gene microRNA 449a Neighboring gene glutathione peroxidase 8 (putative) Neighboring gene RIKEN cDNA 1700084D21 gene Neighboring gene granzyme K

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
granzyme A
Names
BLT esterase
H factor
Hanukah factor
autocrine thymic lymphoma granzyme-like serine protease
fragmentin-1
serine esterase 1
t cell-specific serine protease 1
NP_034500.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010370.3NP_034500.1  granzyme A precursor

    See identical proteins and their annotated locations for NP_034500.1

    Status: VALIDATED

    Source sequence(s)
    BC061146, EH095037
    Consensus CDS
    CCDS26782.1
    UniProtKB/Swiss-Prot
    P11032
    UniProtKB/TrEMBL
    Q3U0N0
    Related
    ENSMUSP00000023897.6, ENSMUST00000023897.7
    Conserved Domains (2) summary
    smart00020
    Location:28252
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:29255
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    113230358..113237515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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