Format

Send to:

Choose Destination

H2-Aa histocompatibility 2, class II antigen A, alpha [ Mus musculus (house mouse) ]

Gene ID: 14960, updated on 23-Jun-2021

Summary

Official Symbol
H2-Aaprovided by MGI
Official Full Name
histocompatibility 2, class II antigen A, alphaprovided by MGI
Primary source
MGI:MGI:95895
See related
Ensembl:ENSMUSG00000036594
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A; I; I-; Ia; H-2; Ia1; H2Aa; Ia-1; H-2Aa; Aalpha; IAalpha; I-Aalpha
Expression
Biased expression in spleen adult (RPKM 791.4), large intestine adult (RPKM 638.1) and 14 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See H2-Aa in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34501718..34506797, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34282744..34287823, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34419696..34424716, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 20506 Neighboring gene histocompatibility 2, class II antigen A, beta 1 Neighboring gene histocompatibility 2, class II antigen E beta Neighboring gene histocompatibility 2, class II antigen E beta2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MHC class II protein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptide antigen binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within antigen processing and presentation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within antigen processing and presentation of peptide antigen IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IEA
Inferred from Electronic Annotation
more info
 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in immunoglobulin production involved in immunoglobulin-mediated immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptide antigen assembly with MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of T cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to interferon-gamma IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of MHC class II protein complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histocompatibility 2, class II antigen A, alpha
Names
H-2 class II histocompatibility antigen, A-B alpha chain
H-2 class II histocompatibility antigen, A-F alpha chain
H-2 class II histocompatibility antigen, A-K alpha chain
H-2 class II histocompatibility antigen, A-Q alpha chain
H-2 class II histocompatibility antigen, A-R alpha chain
H-2 class II histocompatibility antigen, A-S alpha chain
H-2 class II histocompatibility antigen, A-U alpha chain
MHC class II antigen alpha chain
MHC-II I-A(d) alpha
histocompatibility 2, class II antigen A, alpha, promoter 1
major histocompatibility protein class II alpha chain

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010378.3NP_034508.2  histocompatibility 2, class II antigen A, alpha precursor

    See identical proteins and their annotated locations for NP_034508.2

    Status: VALIDATED

    Source sequence(s)
    AK002532, BY604245, CR974422
    Consensus CDS
    CCDS28645.1
    UniProtKB/Swiss-Prot
    P14434
    Related
    ENSMUSP00000046105.7, ENSMUST00000040655.14
    Conserved Domains (3) summary
    cd05767
    Location:113206
    IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00993
    Location:31109
    MHC_II_alpha; Class II histocompatibility antigen, alpha domain
    pfam16196
    Location:204255
    C1-set_C; C1-set C-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34501718..34506797 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center