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H2-Ab1 histocompatibility 2, class II antigen A, beta 1 [ Mus musculus (house mouse) ]

Gene ID: 14961, updated on 6-May-2021

Summary

Official Symbol
H2-Ab1provided by MGI
Official Full Name
histocompatibility 2, class II antigen A, beta 1provided by MGI
Primary source
MGI:MGI:103070
See related
Ensembl:ENSMUSG00000073421
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
I; Ia; Abe; IAb; Ia2; Rmc; H-2A; H2-A; I-A<; I-Ab; Ia-2; Abeta; H-2Ab; H2-Ab; Rmcs1; H2-Ab_; I-Abeta; AI845868
Expression
Biased expression in spleen adult (RPKM 2279.6), large intestine adult (RPKM 1316.2) and 12 other tissues See more
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Genomic context

See H2-Ab1 in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34482201..34488392)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34263227..34269418)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34400172..34406363)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene histocompatibility 2, O region beta locus Neighboring gene predicted gene 20506 Neighboring gene histocompatibility 2, class II antigen A, alpha Neighboring gene histocompatibility 2, class II antigen E beta

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables peptide antigen binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein antigen binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables toxic substance binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell affinity maturation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within antigen processing and presentation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within antigen processing and presentation of peptide antigen IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to interferon-gamma IDA
Inferred from Direct Assay
more info
PubMed 
involved_in humoral immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T-helper 1 type immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of alpha-beta T cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of alpha-beta T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of alpha-beta T cell activation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of antigen processing and presentation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
part_of MHC class II protein complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in multivesicular body IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histocompatibility 2, class II antigen A, beta 1
Names
H-2 class II histocompatibility antigen, A beta chain
MHC class II H2-IA-beta-psi
histocompatibility 2, class II antigen A, beta, promoter 1
major histocompatibility complex class II beta chain
response to metastatic cancers 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207105.3NP_996988.2  histocompatibility 2, class II antigen A, beta 1 precursor

    See identical proteins and their annotated locations for NP_996988.2

    Status: VALIDATED

    Source sequence(s)
    AK077436, BB056841, BY205244, CK330363
    Consensus CDS
    CCDS37583.1
    UniProtKB/Swiss-Prot
    P14483
    UniProtKB/TrEMBL
    Q3TD53, Q8BPA0
    Related
    ENSMUSP00000041008.6, ENSMUST00000040828.7
    Conserved Domains (2) summary
    cd05766
    Location:125218
    IgC_MHC_II_beta; Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain
    pfam00969
    Location:40111
    MHC_II_beta; Class II histocompatibility antigen, beta domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34482201..34488392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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