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Hsd17b8 hydroxysteroid 17-beta dehydrogenase 8 [ Mus musculus (house mouse) ]

Gene ID: 14979, updated on 11-Apr-2024

Summary

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Official Symbol
Hsd17b8provided by MGI
Official Full Name
hydroxysteroid 17-beta dehydrogenase 8provided by MGI
Primary source
MGI:MGI:95911
See related
Ensembl:ENSMUSG00000073422 AllianceGenome:MGI:95911
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ke6; Ke-6; Ring2; H-2Ke6; H2-Ke6; D17H6S112E
Summary
Enables estradiol 17-beta-dehydrogenase activity and testosterone dehydrogenase (NAD+) activity. Acts upstream of or within androgen metabolic process and estrogen metabolic process. Located in mitochondrial envelope and plasma membrane. Is expressed in several structures, including brain; genitourinary system; heart; hemolymphoid system gland; and liver. Orthologous to human HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 155.4), ovary adult (RPKM 72.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 B1; 17 17.98 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34245007..34247029, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34026033..34028055, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 1 Neighboring gene microRNA 219a-1 Neighboring gene microRNA 219c Neighboring gene STARR-positive B cell enhancer ABC_E5594 Neighboring gene solute carrier family 39 (zinc transporter), member 7 Neighboring gene STARR-positive B cell enhancer ABC_E5595 Neighboring gene retinoid X receptor beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Abnormal regulation of the Ke 6 gene, a new 17beta-hydroxysteroid dehydrogenase in the cpk mouse kidney. Ramirez S, et al. Mol Cell Endocrinol, 1998 Aug 25. PMID 9806346
  2. Immature ovaries and polycystic kidneys in the congenital polycystic kidney mouse may be due to abnormal sex steroid metabolism. Woo D, et al. Mol Cell Endocrinol, 2001 May 15. PMID 11369455
  3. Arrested testis development in the cpk mouse may be the result of abnormal steroid metabolism. Aziz N, et al. Mol Cell Endocrinol, 2001 Jan 22. PMID 11165015
  4. Characterization of Ke 6, a new 17beta-hydroxysteroid dehydrogenase, and its expression in gonadal tissues. Fomitcheva J, et al. J Biol Chem, 1998 Aug 28. PMID 9712896
  5. Downregulation of Ke 6, a novel gene encoded within the major histocompatibility complex, in murine polycystic kidney disease. Aziz N, et al. Mol Cell Biol, 1993 Mar. PMID 8441417, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC107650

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables (3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
enables NADH binding ISO
Inferred from Sequence Orthology
more info
  
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables testosterone dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within androgen metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in estrogen biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in estrogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within estrogen metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein heterotetramerization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
part_of oxidoreductase complex ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
(3R)-3-hydroxyacyl-CoA dehydrogenase
Names
17-beta-HSD 8
17-beta-hydroxysteroid dehydrogenase 8
3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit
3-oxoacyl-[acyl-carrier-protein] reductase
H2-K region expressed gene 6
KAR alpha subunit
estradiol 17-beta-dehydrogenase 8
estrogen 17-oxidoreductase
testosterone 17-beta-dehydrogenase 8
NP_038571.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013543.2 → NP_038571.2  (3R)-3-hydroxyacyl-CoA dehydrogenase

    See identical proteins and their annotated locations for NP_038571.2

    Status: VALIDATED

    Source sequence(s)
    BC086927, CX243612
    Consensus CDS
    CCDS50071.1
    UniProtKB/Swiss-Prot
    P50171, Q5M9K0, Q60958, Q60959, Q9Z1W2
    UniProtKB/TrEMBL
    A0A068BEQ2
    Related
    ENSMUSP00000038069.8, ENSMUST00000045467.14
    Conserved Domains (2) summary
    PRK05653
    Location:12 → 259
    fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated
    cl21454
    Location:11 → 258
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34245007..34247029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50171.2 GenPept UniProtKB/Swiss-Prot:P50171

Gene LinkOut

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