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H2-DMb1 histocompatibility 2, class II, locus Mb1 [ Mus musculus (house mouse) ]

Gene ID: 14999, updated on 23-Jun-2021

Summary

Official Symbol
H2-DMb1provided by MGI
Official Full Name
histocompatibility 2, class II, locus Mb1provided by MGI
Primary source
MGI:MGI:95922
See related
Ensembl:ENSMUSG00000079547
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H-2Mb1; H2-Mb1; AI385589
Expression
Biased expression in spleen adult (RPKM 164.1), large intestine adult (RPKM 97.0) and 11 other tissues See more
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Genomic context

See H2-DMb1 in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34372165..34379203)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34153191..34160229)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34290136..34297174)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene bromodomain containing 2 Neighboring gene histocompatibility 2, class II, locus DMa Neighboring gene histocompatibility 2, class II, locus Mb2 Neighboring gene proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) Neighboring gene transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MHC class II protein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MHC class II protein complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in MHC class II protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within antigen processing and presentation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chaperone cofactor-dependent protein refolding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in immunoglobulin production involved in immunoglobulin-mediated immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptide antigen assembly with MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptide antigen assembly with MHC class II protein complex ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of MHC class II protein complex ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
class II histocompatibility antigen, M beta 1 chain
Names
H2-M beta 1 chain
H2-M beta1
MHC class II antigen Mb1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010387.3NP_034517.2  class II histocompatibility antigen, M beta 1 chain precursor

    See identical proteins and their annotated locations for NP_034517.2

    Status: VALIDATED

    Source sequence(s)
    AK032745
    Consensus CDS
    CCDS37581.1
    UniProtKB/TrEMBL
    Q31094
    Related
    ENSMUSP00000109870.3, ENSMUST00000114232.4
    Conserved Domains (3) summary
    smart00410
    Location:129201
    IG_like; Immunoglobulin like
    pfam00969
    Location:27106
    MHC_II_beta; Class II histocompatibility antigen, beta domain
    cl11960
    Location:115209
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34372165..34379203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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