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H2-DMb2 histocompatibility 2, class II, locus Mb2 [ Mus musculus (house mouse) ]

Gene ID: 15000, updated on 23-Jun-2021

Summary

Official Symbol
H2-DMb2provided by MGI
Official Full Name
histocompatibility 2, class II, locus Mb2provided by MGI
Primary source
MGI:MGI:95923
See related
Ensembl:ENSMUSG00000037548
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H-2Mb2; H2-Mb2
Expression
Biased expression in spleen adult (RPKM 391.6), mammary gland adult (RPKM 128.8) and 7 other tissues See more
Orthologs
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Genomic context

See H2-DMb2 in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34362203..34370527)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34143229..34151553)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34282361..34288040)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC051537 Neighboring gene histocompatibility 2, O region alpha locus Neighboring gene bromodomain containing 2 Neighboring gene histocompatibility 2, class II, locus DMa Neighboring gene histocompatibility 2, class II, locus Mb1 Neighboring gene proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MHC class II protein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MHC class II protein complex binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in MHC class II protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within antigen processing and presentation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within antigen processing and presentation ISA
Inferred from Sequence Alignment
more info
PubMed 
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chaperone cofactor-dependent protein refolding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in immunoglobulin production involved in immunoglobulin-mediated immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptide antigen assembly with MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptide antigen assembly with MHC class II protein complex ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of MHC class II protein complex ISO
Inferred from Sequence Orthology
more info
 
located_in endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in multivesicular body IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histocompatibility 2, class II, locus Mb2
Names
H2-M beta2
MHC class II antigen Mb2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010388.5NP_034518.1  histocompatibility 2, class II, locus Mb2 precursor

    See identical proteins and their annotated locations for NP_034518.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    CR974422
    Consensus CDS
    CCDS37580.1
    UniProtKB/TrEMBL
    Q31099
    Related
    ENSMUSP00000043526.8, ENSMUST00000041982.9
    Conserved Domains (3) summary
    smart00410
    Location:129201
    IG_like; Immunoglobulin like
    pfam00969
    Location:27106
    MHC_II_beta; Class II histocompatibility antigen, beta domain
    cl11960
    Location:115209
    Ig; Immunoglobulin domain

RNA

  1. NR_160895.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CR974422
    Related
    ENSMUST00000171231.8
  2. NR_160896.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CR974422
    Related
    ENSMUST00000236519.2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34362203..34370527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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