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H2-Oa histocompatibility 2, O region alpha locus [ Mus musculus (house mouse) ]

Gene ID: 15001, updated on 23-Jun-2021

Summary

Official Symbol
H2-Oaprovided by MGI
Official Full Name
histocompatibility 2, O region alpha locusprovided by MGI
Primary source
MGI:MGI:95924
See related
Ensembl:ENSMUSG00000024334
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H-2; H-2Oa
Expression
Biased expression in spleen adult (RPKM 116.7), thymus adult (RPKM 40.6) and 3 other tissues See more
Orthologs
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Genomic context

See H2-Oa in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34311353..34314286)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34092379..34095234)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34229324..34232179)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene histocompatibility 2, P region beta locus Neighboring gene cDNA sequence BC051537 Neighboring gene histocompatibility 2, P region alpha locus Neighboring gene bromodomain containing 2 Neighboring gene histocompatibility 2, class II, locus DMa Neighboring gene histocompatibility 2, class II, locus Mb2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MHC class II protein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MHC class II protein complex binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of MHC class II protein complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histocompatibility 2, O region alpha locus
Names
MHC class II antigen O region alpha locus

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008206.2NP_032232.2  histocompatibility 2, O region alpha locus precursor

    See identical proteins and their annotated locations for NP_032232.2

    Status: VALIDATED

    Source sequence(s)
    AK020594, BC138996, CO795887
    Consensus CDS
    CCDS37577.1
    UniProtKB/TrEMBL
    B2RST7, Q9QWV1
    Related
    ENSMUSP00000025192.8, ENSMUST00000025192.8
    Conserved Domains (3) summary
    cd05767
    Location:112205
    IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00993
    Location:30108
    MHC_II_alpha; Class II histocompatibility antigen, alpha domain
    pfam16196
    Location:203250
    C1-set_C; C1-set C-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34311353..34314286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160330.1XP_036016223.1  histocompatibility 2, O region alpha locus isoform X1

    Conserved Domains (2) summary
    pfam00993
    Location:178
    MHC_II_alpha; Class II histocompatibility antigen, alpha domain
    cd21004
    Location:81175
    IgC1_MHC_II_alpha_HLA_DO; HLA class II histocompatibility antigen DO alpha; member of the C1-set of Ig superfamily (IgSF) domains
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