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H2-Ob histocompatibility 2, O region beta locus [ Mus musculus (house mouse) ]

Gene ID: 15002, updated on 15-Jun-2021

Summary

Official Symbol
H2-Obprovided by MGI
Official Full Name
histocompatibility 2, O region beta locusprovided by MGI
Primary source
MGI:MGI:95925
See related
Ensembl:ENSMUSG00000041538
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
O; Ob; vi; H-2; H-2I; H-2O; H2-A; vic1; A-bet; H-2Ab; H-2Ob; H2-Ab; H2-IA; A-beta; H2-Ab2; A-beta2; H2-IAb2; A-beta-2
Expression
Biased expression in spleen adult (RPKM 49.9), mammary gland adult (RPKM 16.4) and 3 other tissues See more
Orthologs
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Genomic context

See H2-Ob in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34457879..34464882)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34238905..34245908)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34375850..34382853)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) Neighboring gene transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) Neighboring gene predicted gene 20506 Neighboring gene histocompatibility 2, class II antigen A, beta 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MHC class II protein complex binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of MHC class II protein complex ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histocompatibility 2, O region beta locus
Names
H2-IA-beta-2 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010389.3NP_034519.2  histocompatibility 2, O region beta locus precursor

    See identical proteins and their annotated locations for NP_034519.2

    Status: VALIDATED

    Source sequence(s)
    AF027865, AK053233, AK155650, BY205160
    Consensus CDS
    CCDS37582.1
    UniProtKB/TrEMBL
    O35424, Q3U1X7
    Related
    ENSMUSP00000092985.4, ENSMUST00000095342.11
    Conserved Domains (2) summary
    pfam00969
    Location:39113
    MHC_II_beta; Class II histocompatibility antigen, beta domain
    cl11960
    Location:123214
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34457879..34464882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523686.3XP_006523749.1  histocompatibility 2, O region beta locus isoform X1

    See identical proteins and their annotated locations for XP_006523749.1

    Conserved Domains (2) summary
    cl03042
    Location:142
    MHC_II_beta; Class II histocompatibility antigen, beta domain
    cl11960
    Location:52143
    Ig; Immunoglobulin domain
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