H2-T24 histocompatibility 2, T region locus 24 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: H2-T24provided by MGI
Official Full Name: histocompatibility 2, T region locus 24provided by MGI
Primary source: MGI:MGI:95958
See related: Ensembl:ENSMUSG00000053835 AllianceGenome:MGI:95958
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: H-2T24
Summary: Predicted to enable peptide antigen binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and small intestine. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 11.8), thymus adult (RPKM 8.7) and 26 other tissues See more
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 17 B1; 17 18.84 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (36314363..36331689, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (36003471..36020800, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

Go to the top of the page Help

Markers

L22338 (e-PCR)
- UniSTS:163587

NoName (e-PCR)
- UniSTS:489062

H2-T24 (e-PCR), detects polymorphism
- UniSTS:525243

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peptide antigen binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	IBA Inferred from Biological aspect of Ancestor more info
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: histocompatibility 2, T region locus 24

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008207.3 → NP_032233.2 histocompatibility 2, T region locus 24 precursor

See identical proteins and their annotated locations for NP_032233.2

Status: VALIDATED

Source sequence(s)

AC112970

Consensus CDS

CCDS37607.1

UniProtKB/TrEMBL

F8VQG4, Q9XRZ3

Related

ENSMUSP00000109389.4, ENSMUST00000113760.10

Conserved Domains (2) summary

cd07698
Location:208 → 300

IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain

cl08246
Location:19 → 203

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2