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H3f3b H3.3 histone B [ Mus musculus (house mouse) ]

Gene ID: 15081, updated on 23-Jun-2021

Summary

Official Symbol
H3f3bprovided by MGI
Official Full Name
H3.3 histone Bprovided by MGI
Primary source
MGI:MGI:1101768
See related
Ensembl:ENSMUSG00000016559
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H3-3a; H3-3b; H3.3B; 9430068D06Rik
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded by this gene is a replication-independent histone that is a member of the histone H3 family. [provided by RefSeq, Nov 2015]
Expression
Broad expression in CNS E14 (RPKM 263.1), whole brain E14.5 (RPKM 256.7) and 26 other tissues See more
Orthologs
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Genomic context

See H3f3b in Genome Data Viewer
Location:
11; 11 E2
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115912787..115921313, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116021961..116026039, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (115883275..115885818, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene integrin beta 4 Neighboring gene RIKEN cDNA B230344G16 gene Neighboring gene galactokinase 1 Neighboring gene unkempt family zinc finger Neighboring gene predicted gene, 38482 Neighboring gene unc-13 homolog D

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in DNA replication-independent nucleosome assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryo implantation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of chromosome condensation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in nucleosome assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nucleus organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within oogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within osteoblast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within pericentric heterochromatin assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of centromere complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within single fertilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within subtelomeric heterochromatin assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear chromosome ISO
Inferred from Sequence Orthology
more info
 
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histone H3.3
Names
H3 histone, family 3B
H3L-like histone

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008211.3NP_032237.1  histone H3.3

    See identical proteins and their annotated locations for NP_032237.1

    Status: REVIEWED

    Source sequence(s)
    AK151336, AK153530, AK161675, AV112938, BY685958
    Consensus CDS
    CCDS36377.1
    UniProtKB/Swiss-Prot
    P84244
    Related
    ENSMUSP00000016703.8, ENSMUST00000016703.8
    Conserved Domains (1) summary
    PTZ00018
    Location:1136
    PTZ00018; histone H3; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    115912787..115921313 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532248.4XP_006532311.1  histone H3.3 isoform X1

    See identical proteins and their annotated locations for XP_006532311.1

    UniProtKB/Swiss-Prot
    P84244
    Related
    ENSMUSP00000102062.2, ENSMUST00000106454.8
    Conserved Domains (1) summary
    PTZ00018
    Location:1136
    PTZ00018; histone H3; Provisional
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