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Hadh hydroxyacyl-Coenzyme A dehydrogenase [ Mus musculus (house mouse) ]

Gene ID: 15107, updated on 18-Apr-2024

Summary

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Official Symbol
Hadhprovided by MGI
Official Full Name
hydroxyacyl-Coenzyme A dehydrogenaseprovided by MGI
Primary source
MGI:MGI:96009
See related
Ensembl:ENSMUSG00000027984 AllianceGenome:MGI:96009
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HCDH; Schad; Hadhsc
Summary
Enables 3-hydroxyacyl-CoA dehydrogenase activity. Involved in positive regulation of cold-induced thermogenesis and regulation of insulin secretion. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 4. Orthologous to human HADH (hydroxyacyl-CoA dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 232.8), kidney adult (RPKM 182.9) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 G3; 3 60.86 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (131027068..131065750, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (131233419..131272101, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08995 Neighboring gene predicted gene, 36603 Neighboring gene STARR-positive B cell enhancer ABC_E6127 Neighboring gene lymphoid enhancer binding factor 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:130860450-130860637 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:130911499-130911865 Neighboring gene STARR-positive B cell enhancer ABC_E6128 Neighboring gene TatD DNase domain containing 2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E11712 Neighboring gene cytochrome P450, family 2, subfamily u, polypeptide 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Hypoglycemic Phenotype Is Islet Cell-Autonomous in Short-Chain Hydroxyacyl-CoA Dehydrogenase-Deficient Mice. Molven A, et al. Diabetes, 2016 Jun. PMID 26953163, Free PMC Article
  2. Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents. Hardy OT, et al. Mol Endocrinol, 2007 Mar. PMID 17185391
  3. L-3-hydroxyacyl-CoA dehydrogenase II protects in a model of Parkinson's disease. Tieu K, et al. Ann Neurol, 2004 Jul. PMID 15236401
  4. Isolation of a cDNA clone encoding mouse 3-hydroxyacyl CoA dehydrogenase. Nomura M, et al. Gene, 1995 Jul 28. PMID 7642117
  5. Hadh deficiency induced oligoasthenoteratozoospermia through the TNF-α/Bcl-2 pathway in male mice. Zhu H, et al. FASEB J, 2022 Dec. PMID 36398584

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hadh deficiency induced oligoasthenoteratozoospermia through the TNF-alpha/Bcl-2 pathway in male mice.
    Title: Hadh deficiency induced oligoasthenoteratozoospermia through the TNF-α/Bcl-2 pathway in male mice.
  2. A physical association between short-chain 3-hydroxyacyl-coenzyme A dehydrogenase and important components of other key metabolic pathways. Most of the interactions were with enzymes in mitochondrial pathways.
    Title: Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways.
  3. SCHAD is involved in thermogenesis, in the maintenance of body weight, and in the regulation of nutrient-stimulated insulin secretion
    Title: Role of medium- and short-chain L-3-hydroxyacyl-CoA dehydrogenase in the regulation of body weight and thermogenesis.
  4. SCHAD deficiency causes hyperinsulinism by activation of GDH via loss of inhibitory regulation of GDH by SCHAD.
    Title: Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase.
  5. SCHAD regulates insulin secretion through a KATP channel-independent mechanism.
    Title: Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents.
  6. Results demonstrate that L-3-hydroxyacyl-CoA dehydrogenase type II (HADH II/ABAD) modulates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity and suggests that mimetics may provide protective benefit in the treatment of Parkinson disease.
    Title: L-3-hydroxyacyl-CoA dehydrogenase II protects in a model of Parkinson's disease.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-hydroxyacyl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-hydroxyacyl-CoA dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-hydroxyacyl-CoA dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables NAD+ binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to activity ISO
Inferred from Sequence Orthology
more info
  
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
Names
L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain
hydroxylacyl-Coenzyme A dehydrogenase-dehydrogenase
medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase
short-chain 3-hydroxyacyl-CoA dehydrogenase
NP_032238.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008212.4 → NP_032238.2  hydroxyacyl-coenzyme A dehydrogenase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_032238.2

    Status: VALIDATED

    Source sequence(s)
    AC123634, AI845880, AK132260, AK148486
    Consensus CDS
    CCDS38640.1
    UniProtKB/Swiss-Prot
    Q3TF75, Q3THK8, Q3UFI0, Q61425, Q8K149, Q925U9
    Related
    ENSMUSP00000029610.9, ENSMUST00000029610.9
    Conserved Domains (3) summary
    COG1250
    Location:27 → 313
    FadB; 3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]
    pfam00725
    Location:216 → 313
    3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
    pfam02737
    Location:29 → 214
    3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    131027068..131065750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61425.2 GenPept UniProtKB/Swiss-Prot:Q61425

Gene LinkOut

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