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Hal histidine ammonia lyase [ Mus musculus (house mouse) ]

Gene ID: 15109, updated on 6-Jun-2021

Summary

Official Symbol
Halprovided by MGI
Official Full Name
histidine ammonia lyaseprovided by MGI
Primary source
MGI:MGI:96010
See related
Ensembl:ENSMUSG00000020017
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hs; Hsd; his; hist; histidase
Summary
This gene encodes a member of the histidase protein family. The encoded protein is a cytosolic enzyme which catalyzes the first reaction in histidine catabolism. Defects in this protein cause histidinemia, which is characterized by increased histidine in blood, urine, and cerebrospinal fluid. [provided by RefSeq, Dec 2015]
Expression
Restricted expression toward liver adult (RPKM 120.3) See more
Orthologs
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Genomic context

See Hal in Genome Data Viewer
Location:
10 C2; 10 48.49 cM
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (93324630..93352623)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (93488768..93516761)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (92951513..92979488)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC115487419 Neighboring gene nuclear encoded tRNA aspartic acid 8 (anticodon GTC) Neighboring gene leukotriene A4 hydrolase Neighboring gene amidohydrolase domain containing 1 Neighboring gene coiled-coil domain containing 38 Neighboring gene small nuclear ribonucleoprotein polypeptide F

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ammonia-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables histidine ammonia-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histidine ammonia-lyase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histidine ammonia-lyase activity ISO
Inferred from Sequence Orthology
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in histidine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within histidine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within histidine metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
histidine ammonia-lyase
NP_034531.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010401.4NP_034531.1  histidine ammonia-lyase

    See identical proteins and their annotated locations for NP_034531.1

    Status: REVIEWED

    Source sequence(s)
    AK014518, AK028963
    Consensus CDS
    CCDS36036.1
    UniProtKB/Swiss-Prot
    P35492
    UniProtKB/TrEMBL
    B2RXW1, Q8CE60
    Related
    ENSMUSP00000123336.2, ENSMUST00000129421.8
    Conserved Domains (2) summary
    TIGR01225
    Location:114625
    hutH; histidine ammonia-lyase
    pfam12053
    Location:1578
    DUF3534; Domain of unknown function (DUF3534)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    93324630..93352623
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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