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Hebp1 heme binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 15199, updated on 30-Apr-2024

Summary

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Official Symbol
Hebp1provided by MGI
Official Full Name
heme binding protein 1provided by MGI
Primary source
MGI:MGI:1333880
See related
Ensembl:ENSMUSG00000042770 AllianceGenome:MGI:1333880
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hebp; p22HBP
Summary
Enables heme binding activity. Predicted to act upstream of or within heme metabolic process. Located in cytosol. Orthologous to human HEBP1 (heme binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 81.5), liver adult (RPKM 79.6) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 G1; 6 65.93 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (135114517..135145213, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (135137519..135168215, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor, family C, group 5, member D Neighboring gene Hebp1R1 erythroid cis-regulatory module Neighboring gene STARR-seq mESC enhancer starr_17563 Neighboring gene fucose mutarotase-like Neighboring gene Hebp1R3 erythroid cis-regulatory module Neighboring gene predicted gene, 22881 Neighboring gene Hebp1R2 erythroid cis-regulatory module Neighboring gene predicted gene, 34391 Neighboring gene predicted gene, 19434 Neighboring gene predicted gene, 36533

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Heme-binding protein 1 delivered via pericyte-derived extracellular vesicles improves neurovascular regeneration in a mouse model of cavernous nerve injury. Ock J, et al. Int J Biol Sci, 2023. PMID 37324943, Free PMC Article
  2. Pericyte-derived heme-binding protein 1 promotes angiogenesis and improves erectile function in diabetic mice. Yin GN. Investig Clin Urol, 2022 Jul. PMID 35796141, Free PMC Article
  3. Transcriptional profiling of mouse cavernous pericytes under high-glucose conditions: Implications for diabetic angiopathy. Yin GN, et al. Investig Clin Urol, 2021 Jan. PMID 33258327, Free PMC Article
  4. Tetrapyrrole binding affinity of the murine and human p22HBP heme-binding proteins. Micaelo NM, et al. J Mol Graph Model, 2010 Nov. PMID 20800521
  5. SOUL in mouse eyes is a new hexameric heme-binding protein with characteristic optical absorption, resonance Raman spectral, and heme-binding properties. Sato E, et al. Biochemistry, 2004 Nov 9. PMID 15518569

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Heme-binding protein 1 delivered via pericyte-derived extracellular vesicles improves neurovascular regeneration in a mouse model of cavernous nerve injury.
    Title: Heme-binding protein 1 delivered via pericyte-derived extracellular vesicles improves neurovascular regeneration in a mouse model of cavernous nerve injury.
  2. Pericyte-derived heme-binding protein 1 promotes angiogenesis and improves erectile function in diabetic mice.
    Title: Pericyte-derived heme-binding protein 1 promotes angiogenesis and improves erectile function in diabetic mice.
  3. Transcriptional profiling of mouse cavernous pericytes under high-glucose conditions: Implications for diabetic angiopathy.
    Title: Transcriptional profiling of mouse cavernous pericytes under high-glucose conditions: Implications for diabetic angiopathy.
  4. Results present a systematic molecular modeling study of the binding properties of murine and human p22HBP protein (heme-binding protein) with four tetrapyrrole ring systems belonging to the heme biosynthetic pathway.
    Title: Tetrapyrrole binding affinity of the murine and human p22HBP heme-binding proteins.
  5. mouse neutrophils, which like macrophages and dendritic cells express Fpr2, responded to human and mouse F2L in both calcium flux and chemotaxis assays
    Title: F2L, a peptide derived from heme-binding protein, chemoattracts mouse neutrophils by specifically activating Fpr2, the low-affinity N-formylpeptide receptor.
  6. Characterization as a tetrapyrrole-binding protein
    Title: Characterization of a human and mouse tetrapyrrole-binding protein.
  7. The heme-binding properties and coordination structure of mouse liver p22HBP are distinct from those of SOUL protein, despite high sequence homology.
    Title: SOUL in mouse eyes is a new hexameric heme-binding protein with characteristic optical absorption, resonance Raman spectral, and heme-binding properties.
  8. analysis of murine P22HBP structure
    Title: The first structure from the SOUL/HBP family of heme-binding proteins, murine P22HBP.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within heme metabolic process IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
heme-binding protein 1
Names
p22 HBP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013546.3 → NP_038574.3  heme-binding protein 1

    Status: VALIDATED

    Source sequence(s)
    AC131718, AI527209, AK008919, BY242687
    Consensus CDS
    CCDS20645.1
    UniProtKB/Swiss-Prot
    O88814, Q9R257
    UniProtKB/TrEMBL
    A0A140T8J4
    Related
    ENSMUSP00000042232.8, ENSMUST00000045855.9
    Conserved Domains (1) summary
    pfam04832
    Location:13 → 188
    SOUL; SOUL heme-binding protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    135114517..135145213 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241224.3 → XP_011239526.1  heme-binding protein 1 isoform X1

    Conserved Domains (1) summary
    pfam04832
    Location:60 → 222
    SOUL; SOUL heme-binding protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R257.2 GenPept UniProtKB/Swiss-Prot:Q9R257

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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