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ROPN1B rhophilin associated tail protein 1B [ Homo sapiens (human) ]

Gene ID: 152015, updated on 5-Mar-2024

Summary

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Official Symbol
ROPN1Bprovided by HGNC
Official Full Name
rhophilin associated tail protein 1Bprovided by HGNC
Primary source
HGNC:HGNC:31927
See related
Ensembl:ENSG00000114547 AllianceGenome:HGNC:31927
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables protein heterodimerization activity. Predicted to be involved in several processes, including flagellated sperm motility; protein localization to cilium; and sperm capacitation. Located in cytoplasm and motile cilium. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 113.4) See more
Orthologs
all
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Genomic context

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See ROPN1B in Genome Data Viewer
Location:
3q21.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (125969178..125983454)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (128701549..128715814)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (125688021..125702297)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:125635188-125635778 Neighboring gene family with sequence similarity 86, member A pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:125650034-125650534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:125650535-125651035 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:125655344-125655844 Neighboring gene ALG1 like 1, pseudogene Neighboring gene FBRSL1 pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:125736296-125736478 Neighboring gene solute carrier family 41 member 3 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr3:125740258-125741040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:125744116-125744616 Neighboring gene uncharacterized LOC124909425 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:125777675-125778174 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14672 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14673 Neighboring gene ALDH1L1 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella. Fujita A, et al. J Cell Sci, 2000 Jan. PMID 10591629
  2. Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA. Carr DW, et al. J Biol Chem, 2001 May 18. PMID 11278869
  3. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article
  4. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor complex adaptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in Rho protein signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in acrosome reaction NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell-cell adhesion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cilium organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cytoskeleton-dependent cytokinesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in flagellated sperm motility TAS
Traceable Author Statement
more info
 PubMed 
involved_in fusion of sperm to egg plasma membrane involved in single fertilization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein localization to cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sperm capacitation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sperm capacitation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spermatogenesis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ropporin-1B
Names
AKAP-binding sperm protein ropporin
rhophilin-associated protein 1B
ropporin, rhophilin associated protein 1B
testis tissue sperm-binding protein Li 83P

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012337.3 → NP_001012337.1  ropporin-1B

    See identical proteins and their annotated locations for NP_001012337.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF231410, HY006578
    Consensus CDS
    CCDS33841.1
    UniProtKB/Swiss-Prot
    D3DNA6, Q96BM7, Q9BZX4
    UniProtKB/TrEMBL
    A0A140VKG6
    Related
    ENSP00000251776.4, ENST00000251776.8
    Conserved Domains (1) summary
    cl02594
    Location:12 → 44
    DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains

  2. NM_001308313.2 → NP_001295242.1  ropporin-1B

    See identical proteins and their annotated locations for NP_001295242.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC141849, DC397187
    Consensus CDS
    CCDS33841.1
    UniProtKB/Swiss-Prot
    D3DNA6, Q96BM7, Q9BZX4
    UniProtKB/TrEMBL
    A0A140VKG6
    Related
    ENSP00000426271.1, ENST00000514116.6
    Conserved Domains (1) summary
    cl02594
    Location:12 → 44
    DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    125969178..125983454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713513.4 → XP_006713576.1  ropporin-1B isoform X1

    See identical proteins and their annotated locations for XP_006713576.1

    UniProtKB/Swiss-Prot
    D3DNA6, Q96BM7, Q9BZX4
    UniProtKB/TrEMBL
    A0A140VKG6
    Conserved Domains (1) summary
    cl02594
    Location:12 → 44
    DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains

  2. XM_005247138.4 → XP_005247195.1  ropporin-1B isoform X2

    See identical proteins and their annotated locations for XP_005247195.1

    UniProtKB/Swiss-Prot
    Q9BZX4
    Related
    ENSP00000421662.1, ENST00000505382.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    128701549..128715814
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054345358.1 → XP_054201333.1  ropporin-1B isoform X1

    UniProtKB/Swiss-Prot
    D3DNA6, Q96BM7, Q9BZX4
    UniProtKB/TrEMBL
    A0A140VKG6

  2. XM_054345359.1 → XP_054201334.1  ropporin-1B isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BZX4.1 GenPept UniProtKB/Swiss-Prot:Q9BZX4

Gene LinkOut

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