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ZCWPW2 zinc finger CW-type and PWWP domain containing 2 [ Homo sapiens (human) ]

Gene ID: 152098, updated on 5-Mar-2024

Summary

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Official Symbol
ZCWPW2provided by HGNC
Official Full Name
zinc finger CW-type and PWWP domain containing 2provided by HGNC
Primary source
HGNC:HGNC:23574
See related
Ensembl:ENSG00000206559 AllianceGenome:HGNC:23574
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZCW2
Summary
Enables methylated histone binding activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 1.3), fat (RPKM 0.5) and 25 other tissues See more
Orthologs
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Genomic context

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See ZCWPW2 in Genome Data Viewer
Location:
3p24.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (28348721..28526358)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (28350777..28528247)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (28390212..28567849)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377008 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14155 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19620 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:28240525-28241724 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14156 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:28390429-28391409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19621 Neighboring gene C-X9-C motif containing 1 Neighboring gene 5-azacytidine induced 2 Neighboring gene CIAO2A pseudogene 1 Neighboring gene ribosomal protein L34 pseudogene 11 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:28546269-28547201 Neighboring gene protein transport protein SEC31-like Neighboring gene long intergenic non-protein coding RNA 693 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14157 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:28798150-28799349 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:28992829-28994028 Neighboring gene uncharacterized LOC105377009

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Molecular characterization of a human monoclonal antibody to B antigen in ABO blood type. Kaneko M, et al. Immunol Lett, 2003 Mar 3. PMID 12600744
  2. PRDM9 losses in vertebrates are coupled to those of paralogs ZCWPW1 and ZCWPW2. Cavassim MIA, et al. Proc Natl Acad Sci U S A, 2022 Mar 1. PMID 35217607, Free PMC Article
  3. Family-wide Characterization of Histone Binding Abilities of Human CW Domain-containing Proteins. Liu Y, et al. J Biol Chem, 2016 Apr 22. PMID 26933034, Free PMC Article
  4. The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants. Perry J, et al. Trends Biochem Sci, 2003 Nov. PMID 14607086
  5. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? Nathan JA, et al. EMBO J, 2013 Feb 20. PMID 23314748, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PRDM9 losses in vertebrates are coupled to those of paralogs ZCWPW1 and ZCWPW2.
    Title: PRDM9 losses in vertebrates are coupled to those of paralogs ZCWPW1 and ZCWPW2.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger CW-type PWWP domain protein 2
Names
zinc finger CW-type and PWWP domain 2
zinc finger, CW type with PWWP domain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040432.4 → NP_001035522.1  zinc finger CW-type PWWP domain protein 2 isoform a

    See identical proteins and their annotated locations for NP_001035522.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1). Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC093142, AC098616, BC094696, BU508346, DB306158, DB451817
    Consensus CDS
    CCDS33723.1
    UniProtKB/Swiss-Prot
    Q504Y3
    Related
    ENSP00000373278.2, ENST00000383768.7
    Conserved Domains (2) summary
    pfam07496
    Location:30 → 77
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:97 → 160
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

  2. NM_001324169.2 → NP_001311098.1  zinc finger CW-type PWWP domain protein 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2). Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC093142, AC098616
    Consensus CDS
    CCDS33723.1
    UniProtKB/Swiss-Prot
    Q504Y3
    Conserved Domains (2) summary
    pfam07496
    Location:30 → 77
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:97 → 160
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

  3. NM_001324170.2 → NP_001311099.1  zinc finger CW-type PWWP domain protein 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3)
    Source sequence(s)
    AC093142, AC098616

RNA

  1. NR_136708.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4)
    Source sequence(s)
    AC093142, AC098616

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    28348721..28526358
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    28350777..28528247
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q504Y3.1 GenPept UniProtKB/Swiss-Prot:Q504Y3

Gene LinkOut

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