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TMEM161B transmembrane protein 161B [ Homo sapiens (human) ]

Gene ID: 153396, updated on 3-Apr-2024

Summary

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Official Symbol
TMEM161Bprovided by HGNC
Official Full Name
transmembrane protein 161Bprovided by HGNC
Primary source
HGNC:HGNC:28483
See related
Ensembl:ENSG00000164180 AllianceGenome:HGNC:28483
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FLB3342; PRO1313
Summary
Predicted to enable nucleic acid binding activity. Predicted to be involved in DNA integration. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 2.9), thyroid (RPKM 2.5) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
5q14.3
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (88185570..88268845, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (88666901..88750114, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (87484133..87564662, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901023 Neighboring gene VISTA enhancer hs266 Neighboring gene VISTA enhancer hs267 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:87253511-87254010 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:87310460-87310960 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:87310961-87311461 Neighboring gene NANOG hESC enhancer GRCh37_chr5:87345495-87346036 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:87347843-87348384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:87348385-87348925 Neighboring gene uncharacterized LOC105379070 Neighboring gene OCT4 hESC enhancer GRCh37_chr5:87436892-87437393 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:87441563-87442343 Neighboring gene MPRA-validated peak5334 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:87484918-87486117 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:87552812-87553465 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:87564449-87564948 Neighboring gene TMEM161B divergent transcript Neighboring gene RNA, 5S ribosomal pseudogene 187 Neighboring gene RPS3A pseudogene 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Role of rs454214 in Personality mediated Depression and Subjective Well-being. Hou B, et al. Sci Rep, 2020 Mar 30. PMID 32231262, Free PMC Article
  2. TMEM161B modulates radial glial scaffolding in neocortical development. Wang L, et al. Proc Natl Acad Sci U S A, 2023 Jan 24. PMID 36669109, Free PMC Article
  3. The major depressive disorder GWAS-supported variant rs10514299 in TMEM161B-MEF2C predicts putamen activation during reward processing in alcohol dependence. Muench C, et al. Transl Psychiatry, 2018 Jul 13. PMID 30006604, Free PMC Article
  4. Identification of 15 genetic loci associated with risk of major depression in individuals of European descent. Hyde CL, et al. Nat Genet, 2016 Sep. PMID 27479909, Free PMC Article
  5. Genetic loci for retinal arteriolar microcirculation. Sim X, et al. PLoS One, 2013. PMID 23776548, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TMEM161B modulates radial glial scaffolding in neocortical development.
    Title: TMEM161B modulates radial glial scaffolding in neocortical development.
  2. Role of rs454214 in Personality mediated Depression and Subjective Well-being.
    Title: Role of rs454214 in Personality mediated Depression and Subjective Well-being.
  3. The previously identified major depressive disorder risk variant rs10514299 in TMEM161B-MEF2C predicts neuronal correlates of reward processing in an alcohol dependence phenotype, possibly explaining part of the shared pathophysiology and comorbidity between the disorders.
    Title: The major depressive disorder GWAS-supported variant rs10514299 in TMEM161B-MEF2C predicts putamen activation during reward processing in alcohol dependence.
  4. Single nucleotide polymorphism in TMEM161B gene is associated with major depressive disorder.
    Title: Identification of 15 genetic loci associated with risk of major depression in individuals of European descent.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  6. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic loci for retinal arteriolar microcirculation.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC33214

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in regulation of cardiac muscle cell action potential ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of heart rate ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
transmembrane protein 161B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289007.2 → NP_001275936.1  transmembrane protein 161B isoform 1

    See identical proteins and their annotated locations for NP_001275936.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC010243, AK300893, AK301091, DW423642
    Consensus CDS
    CCDS75270.1
    UniProtKB/TrEMBL
    B7Z6X1, E9PCX5
    Related
    ENSP00000426354.1, ENST00000514135.5
    Conserved Domains (2) summary
    pfam10268
    Location:2 → 425
    Tmemb_161AB; Predicted transmembrane protein 161AB
    cl21549
    Location:453 → 494
    rve; Integrase core domain

  2. NM_001289008.2 → NP_001275937.1  transmembrane protein 161B isoform 3

    See identical proteins and their annotated locations for NP_001275937.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region, initiates translation at a downstream start codon and contains an alternate 3' terminal exon, compared to variant 1. It encodes isoform 3, which is shorter and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AC010243, AI570193, AK300893, BX390411, BX647345, DW423642
    Consensus CDS
    CCDS75269.1
    UniProtKB/TrEMBL
    B7Z6T3, B7Z6X1
    Related
    ENSP00000421498.1, ENST00000512429.5
    Conserved Domains (1) summary
    pfam10268
    Location:1 → 473
    Tmemb_161AB; Predicted transmembrane protein 161AB

  3. NM_001349400.2 → NP_001336329.1  transmembrane protein 161B isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 4 which has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform 1. Variants 5-8 encode the same isoform (4).
    Source sequence(s)
    AC010243, AI570193, AK300893, BC037287, BF103799, BX390411, BX647345, DC377704, DW423642
    UniProtKB/TrEMBL
    B7Z6A5
    Conserved Domains (1) summary
    pfam10268
    Location:1 → 302
    Tmemb_161AB; Predicted transmembrane protein 161AB

  4. NM_001349402.2 → NP_001336331.1  transmembrane protein 161B isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 4 which has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform 1. Variants 5-8 encode the same isoform (4).
    Source sequence(s)
    AC010243, AI570193, AK300893, BC037287, BX390411, BX647345, DW423642
    UniProtKB/TrEMBL
    B7Z6A5
    Conserved Domains (1) summary
    pfam10268
    Location:1 → 302
    Tmemb_161AB; Predicted transmembrane protein 161AB

  5. NM_001349403.2 → NP_001336332.1  transmembrane protein 161B isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 4 which has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform 1. Variants 5-8 encode the same isoform (4).
    Source sequence(s)
    AC010243, AI570193, AK300893, AK301091, BC037287, BX390411, BX647345, DW423642
    UniProtKB/TrEMBL
    B7Z6A5
    Conserved Domains (1) summary
    pfam10268
    Location:1 → 302
    Tmemb_161AB; Predicted transmembrane protein 161AB

  6. NM_001349405.2 → NP_001336334.1  transmembrane protein 161B isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 4 which has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform 1. Variants 5-8 encode the same isoform (4).
    Source sequence(s)
    AC010243, AI570193, AK300893, BC037287, BX390411, BX647345, DW423642
    UniProtKB/TrEMBL
    B7Z6A5
    Conserved Domains (1) summary
    pfam10268
    Location:1 → 302
    Tmemb_161AB; Predicted transmembrane protein 161AB

  7. NM_001349407.2 → NP_001336336.1  transmembrane protein 161B isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) has a novel 3' exon structure, resulting in a novel 3' coding region and a distinct 3' UTR compared to variant 1. It encodes isoform 5 which has a longer and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC010243, AK300893, AK301091, DW423642
    UniProtKB/TrEMBL
    B7Z6X1
    Conserved Domains (1) summary
    pfam10268
    Location:2 → 438
    Tmemb_161AB; Predicted transmembrane protein 161AB

  8. NM_153354.5 → NP_699185.1  transmembrane protein 161B isoform 2

    See identical proteins and their annotated locations for NP_699185.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a 3' terminal exon that extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC010243, AI570193, AK300893, BC037287, BX390411, BX647345, DW423642
    Consensus CDS
    CCDS4065.1
    UniProtKB/Swiss-Prot
    Q5CZH7, Q6UWQ6, Q8NDZ6
    UniProtKB/TrEMBL
    B7Z6X1
    Related
    ENSP00000296595.6, ENST00000296595.11
    Conserved Domains (1) summary
    pfam10268
    Location:2 → 484
    Tmemb_161AB; Predicted transmembrane protein 161AB

RNA

  1. NR_110266.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) includes an alternate internal exon and a 3' terminal exon that extends past a splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC010243, AI570193, AK300893, BC037287, BX390411, BX647345, DW423642
    Related
    ENST00000511087.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    88185570..88268845 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024454373.2 → XP_024310141.1  transmembrane protein 161B isoform X8

    UniProtKB/TrEMBL
    B7Z6X1
    Conserved Domains (1) summary
    pfam10268
    Location:29 → 465
    Tmemb_161AB; Predicted transmembrane protein 161AB

  2. XM_047416812.1 → XP_047272768.1  transmembrane protein 161B isoform X5

  3. XM_024454378.2 → XP_024310146.1  transmembrane protein 161B isoform X4

    Conserved Domains (1) summary
    pfam10268
    Location:1 → 353
    Tmemb_161AB; Predicted transmembrane protein 161AB

  4. XM_024454375.2 → XP_024310143.1  transmembrane protein 161B isoform X1

    UniProtKB/TrEMBL
    B7Z6T3, B7Z6X1
    Conserved Domains (1) summary
    pfam10268
    Location:1 → 473
    Tmemb_161AB; Predicted transmembrane protein 161AB

  5. XM_047416811.1 → XP_047272767.1  transmembrane protein 161B isoform X5

  6. XM_047416809.1 → XP_047272765.1  transmembrane protein 161B isoform X5

  7. XM_006714553.2 → XP_006714616.1  transmembrane protein 161B isoform X3

    See identical proteins and their annotated locations for XP_006714616.1

    Conserved Domains (1) summary
    pfam10268
    Location:2 → 364
    Tmemb_161AB; Predicted transmembrane protein 161AB

  8. XM_047416808.1 → XP_047272764.1  transmembrane protein 161B isoform X1

    UniProtKB/TrEMBL
    B7Z6T3

  9. XM_024454376.2 → XP_024310144.1  transmembrane protein 161B isoform X2

    Conserved Domains (1) summary
    pfam10268
    Location:29 → 391
    Tmemb_161AB; Predicted transmembrane protein 161AB

  10. XM_047416810.1 → XP_047272766.1  transmembrane protein 161B isoform X5

  11. XM_047416815.1 → XP_047272771.1  transmembrane protein 161B isoform X7

    Related
    ENSP00000425991.1, ENST00000511218.5

  12. XM_047416813.1 → XP_047272769.1  transmembrane protein 161B isoform X5

  13. XM_047416814.1 → XP_047272770.1  transmembrane protein 161B isoform X6

RNA

  1. XR_002959844.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    88666901..88750114 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351797.1 → XP_054207772.1  transmembrane protein 161B isoform X8

  2. XM_054351790.1 → XP_054207765.1  transmembrane protein 161B isoform X4

  3. XM_054351786.1 → XP_054207761.1  transmembrane protein 161B isoform X1

    UniProtKB/TrEMBL
    B7Z6T3

  4. XM_054351794.1 → XP_054207769.1  transmembrane protein 161B isoform X5

  5. XM_054351793.1 → XP_054207768.1  transmembrane protein 161B isoform X5

  6. XM_054351791.1 → XP_054207766.1  transmembrane protein 161B isoform X5

  7. XM_054351789.1 → XP_054207764.1  transmembrane protein 161B isoform X3

  8. XM_054351787.1 → XP_054207762.1  transmembrane protein 161B isoform X1

    UniProtKB/TrEMBL
    B7Z6T3

  9. XM_054351788.1 → XP_054207763.1  transmembrane protein 161B isoform X2

  10. XM_054351792.1 → XP_054207767.1  transmembrane protein 161B isoform X5

  11. XM_054351796.1 → XP_054207771.1  transmembrane protein 161B isoform X7

  12. XM_054351795.1 → XP_054207770.1  transmembrane protein 161B isoform X5

RNA

  1. XR_008487085.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NDZ6.1 GenPept UniProtKB/Swiss-Prot:Q8NDZ6

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