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Nr4a1 nuclear receptor subfamily 4, group A, member 1 [ Mus musculus (house mouse) ]

Gene ID: 15370, updated on 24-May-2021

Summary

Official Symbol
Nr4a1provided by MGI
Official Full Name
nuclear receptor subfamily 4, group A, member 1provided by MGI
Primary source
MGI:MGI:1352454
See related
Ensembl:ENSMUSG00000023034
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gf; Hm; N1; NP; TI; TR; GFR; Hbr; Hmr; N10; Nur; TR3; Gfrp; Hbr-; Hbr1; NGFI; NP10; TIS1; GFRP1; Hbr-1; NGFIB; nur77; NGFI-B; NUR77-1; NUR77-2
Expression
Biased expression in adrenal adult (RPKM 65.6), thymus adult (RPKM 24.0) and 11 other tissues See more
Orthologs
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Genomic context

See Nr4a1 in Genome Data Viewer
Location:
15; 15 F1
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101151788..101172676)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (101253902..101274795)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (101097277..101105226)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A330009N23 gene Neighboring gene expressed sequence AU021063 Neighboring gene trafficking regulator and scaffold protein tamalin Neighboring gene uncharacterized LOC118568224 Neighboring gene autophagy related 101 Neighboring gene small integral membrane protein 41 Neighboring gene predicted gene, 41403

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Chemically induced (ENU) (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glucocorticoid receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glucocorticoid receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to corticotropin-releasing hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to corticotropin-releasing hormone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to fibroblast growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in endothelial cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of type B pancreatic cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to inorganic substance ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nuclear receptor subfamily 4 group A member 1
Names
hormone receptor
nuclear hormone receptor NUR/77
nuclear protein N10
orphan nuclear receptor HMR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010444.2NP_034574.1  nuclear receptor subfamily 4 group A member 1

    See identical proteins and their annotated locations for NP_034574.1

    Status: VALIDATED

    Source sequence(s)
    AA930162, AK004709, BY292808
    Consensus CDS
    CCDS27848.1
    UniProtKB/Swiss-Prot
    P12813
    UniProtKB/TrEMBL
    Q545Q1
    Related
    ENSMUSP00000023779.7, ENSMUST00000023779.8
    Conserved Domains (2) summary
    cd07348
    Location:364601
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:268342
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    101151788..101172676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248339.2XP_030104199.1  nuclear receptor subfamily 4 group A member 1 isoform X1

    Conserved Domains (2) summary
    cd07348
    Location:364601
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:268342
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
  2. XM_006520456.2XP_006520519.1  nuclear receptor subfamily 4 group A member 1 isoform X1

    See identical proteins and their annotated locations for XP_006520519.1

    UniProtKB/Swiss-Prot
    P12813
    UniProtKB/TrEMBL
    Q545Q1
    Related
    ENSMUSP00000155225.2, ENSMUST00000228985.2
    Conserved Domains (2) summary
    cd07348
    Location:364601
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:268342
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
  3. XM_017316436.3XP_017171925.1  nuclear receptor subfamily 4 group A member 1 isoform X1

    UniProtKB/Swiss-Prot
    P12813
    UniProtKB/TrEMBL
    Q545Q1
    Conserved Domains (2) summary
    cd07348
    Location:364601
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:268342
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
  4. XM_036159163.1XP_036015056.1  nuclear receptor subfamily 4 group A member 1 isoform X1

    Conserved Domains (2) summary
    cd07348
    Location:364601
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:268342
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
  5. XM_006520459.5XP_006520522.1  nuclear receptor subfamily 4 group A member 1 isoform X1

    See identical proteins and their annotated locations for XP_006520522.1

    UniProtKB/Swiss-Prot
    P12813
    UniProtKB/TrEMBL
    Q545Q1
    Conserved Domains (2) summary
    cd07348
    Location:364601
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:268342
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
  6. XM_006520455.2XP_006520518.2  nuclear receptor subfamily 4 group A member 1 isoform X1

    Conserved Domains (2) summary
    cd07348
    Location:364601
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:268342
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

RNA

  1. XR_004938795.1 RNA Sequence

  2. XR_004938796.1 RNA Sequence

  3. XR_004938794.1 RNA Sequence

  4. XR_004938797.1 RNA Sequence

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