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Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 [ Mus musculus (house mouse) ]

Gene ID: 15382, updated on 8-Jul-2021

Summary

Official Symbol
Hnrnpa1provided by MGI
Official Full Name
heterogeneous nuclear ribonucleoprotein A1provided by MGI
Primary source
MGI:MGI:104820
See related
Ensembl:ENSMUSG00000046434
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hd; hn; Hdp; HDP-1; Hnrpa1; hnRNP A1; hnrnp-A1; D15Ertd119
Expression
Biased expression in CNS E11.5 (RPKM 643.9), CNS E14 (RPKM 307.8) and 11 other tissues See more
Orthologs
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Genomic context

See Hnrnpa1 in Genome Data Viewer
Location:
15 F3; 15 58.58 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (103148370..103155125)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (103239943..103246698)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (103070863..103075386)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene single-strand selective monofunctional uracil DNA glycosylase Neighboring gene chromobox 5 Neighboring gene nuclear factor, erythroid derived 2 Neighboring gene coatomer protein complex, subunit zeta 1 Neighboring gene microRNA 148b

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102127, MGC102128, MGC103392, D15Ertd119e

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP-dependent DNA/DNA annealing activity ISO
Inferred from Sequence Orthology
more info
 
enables G-rich strand telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA strand annealing activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables miRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables pre-mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables single-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables telomeric repeat-containing RNA binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nucleoplasmic periphery of the nuclear pore complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
heterogeneous nuclear ribonucleoprotein A1
Names
helix-destabilizing protein
hnRNP core protein A1
single-strand-binding protein
topoisomerase-inhibitor suppressed

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039129.4NP_001034218.1  heterogeneous nuclear ribonucleoprotein A1 isoform b

    See identical proteins and their annotated locations for NP_001034218.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longer isoform (b).
    Source sequence(s)
    AC164069, AK146630, BE949469, BY067931
    Consensus CDS
    CCDS37232.1
    UniProtKB/TrEMBL
    Q5EBP8
    Related
    ENSMUSP00000042658.10, ENSMUST00000036004.16
    Conserved Domains (3) summary
    cd12580
    Location:105181
    RRM2_hnRNPA1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and similar proteins
    cd12761
    Location:1292
    RRM1_hnRNPA1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and similar proteins
    pfam11627
    Location:310345
    HnRNPA1; Nuclear factor hnRNPA1
  2. NM_010447.5NP_034577.1  heterogeneous nuclear ribonucleoprotein A1 isoform a

    See identical proteins and their annotated locations for NP_034577.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an in-frame exon in the central coding region, compared to variant 2. The encoded isoform (a) is shorter, compared to isoform b.
    Source sequence(s)
    AC164069, AK168531, BE949469, BY067931
    Consensus CDS
    CCDS37233.1
    UniProtKB/Swiss-Prot
    P49312
    Related
    ENSMUSP00000084609.8, ENSMUST00000087351.9
    Conserved Domains (3) summary
    pfam11627
    Location:255292
    HnRNPA1; Nuclear factor hnRNPA1
    cd12582
    Location:105184
    RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
    cd12761
    Location:1292
    RRM1_hnRNPA1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and similar proteins

RNA

  1. NR_104427.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 3' exon structure, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC164069, AK007802, BY067931, CJ235774

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    103148370..103155125
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_383983.2 RNA Sequence

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