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Hnrnpab heterogeneous nuclear ribonucleoprotein A/B [ Mus musculus (house mouse) ]

Gene ID: 15384, updated on 8-Jul-2021

Summary

Official Symbol
Hnrnpabprovided by MGI
Official Full Name
heterogeneous nuclear ribonucleoprotein A/Bprovided by MGI
Primary source
MGI:MGI:1330294
See related
Ensembl:ENSMUSG00000020358
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hn; CBF-; Cgbf; CBF-A; Cgbfa; Hnrpab; 3010025C11Rik
Summary
This gene encodes a protein with consensus RNA binding domains present in a number of other RNA binding proteins and a glycine-rich C-terminus. This gene overlaps in a tail-to-tail orientation the gene encoding alanine-glyoxylate aminotransferase 2-like 2. Some of the exons of this gene are interspersed with exons of alanine-glyoxylate aminotransferase 2-like 2. Two alternatively spliced transcript variants that encode distinct proteins have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary adult (RPKM 222.6), CNS E11.5 (RPKM 200.6) and 28 other tissues See more
Orthologs
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Genomic context

See Hnrnpab in Genome Data Viewer
Location:
11; 11 B1.3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (51490927..51497708, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (51600100..51606881, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (51413602..51420383, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC049762 Neighboring gene CDC like kinase 4 Neighboring gene collagen, type XXIII, alpha 1 Neighboring gene 5-phosphohydroxy-L-lysine phospholyase Neighboring gene RIKEN cDNA D930048N14 gene Neighboring gene required for meiotic nuclear division 5 homolog B Neighboring gene NHP2 ribonucleoprotein Neighboring gene NEDD4 binding protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic cytosol IDA
Inferred from Direct Assay
more info
PubMed 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
heterogeneous nuclear ribonucleoprotein A/B
Names
CArG-binding factor-A
S1 protein D2
hnRNP A/B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048061.1NP_001041526.1  heterogeneous nuclear ribonucleoprotein A/B isoform 1

    See identical proteins and their annotated locations for NP_001041526.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AL645602, BQ445737, CA325334, CF751043, CJ166869
    Consensus CDS
    CCDS48787.1
    UniProtKB/TrEMBL
    Q20BD0
    Related
    ENSMUSP00000104731.4, ENSMUST00000109103.4
    Conserved Domains (3) summary
    cd12584
    Location:155234
    RRM2_hnRNPAB; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) and similar proteins
    cd12757
    Location:76150
    RRM1_hnRNPAB; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) and similar proteins
    pfam08143
    Location:175
    CBFNT; CBFNT (NUC161) domain
  2. NM_010448.3NP_034578.1  heterogeneous nuclear ribonucleoprotein A/B isoform 2

    See identical proteins and their annotated locations for NP_034578.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AK013384, CJ166869
    Consensus CDS
    CCDS24654.1
    UniProtKB/Swiss-Prot
    Q99020
    UniProtKB/TrEMBL
    Q544Z3
    Related
    ENSMUSP00000074238.4, ENSMUST00000074669.10
    Conserved Domains (3) summary
    cd12757
    Location:76150
    RRM1_hnRNPAB; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) and similar proteins
    pfam08143
    Location:175
    CBFNT; CBFNT (NUC161) domain
    cl17169
    Location:155234
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    51490927..51497708 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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