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Hrh1 histamine receptor H1 [ Mus musculus (house mouse) ]

Gene ID: 15465, updated on 6-Sep-2021

Summary

Official Symbol
Hrh1provided by MGI
Official Full Name
histamine receptor H1provided by MGI
Primary source
MGI:MGI:107619
See related
Ensembl:ENSMUSG00000053004
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H; Bp; H1R; Hir; Bphs; HH1R
Expression
Biased expression in cortex adult (RPKM 2.2), colon adult (RPKM 1.7) and 14 other tissues See more
Orthologs
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Genomic context

See Hrh1 in Genome Data Viewer
Location:
6 E3; 6 53.05 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (114374897..114460259)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (114397936..114483298)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (114347930..114433290)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 (neurotransmitter transporter, GABA), member 1 Neighboring gene predicted gene, 38875 Neighboring gene autophagy related 7 Neighboring gene predicted gene, 52917 Neighboring gene calmodulin regulated spectrin-associated protein 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables histamine binding ISO
Inferred from Sequence Orthology
more info
 
enables histamine receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within calcium ion import ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within cellular response to histamine ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in eosinophil chemotaxis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within manganese ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of vascular permeability IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histamine H1 receptor
Names
Bordetella pertussis induced histamine sensitization

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252642.2NP_001239571.1  histamine H1 receptor

    See identical proteins and their annotated locations for NP_001239571.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 6. Variants 1 through 6 encode the same protein.
    Source sequence(s)
    AC159381, AK038480, AK046607
    Consensus CDS
    CCDS20435.1
    UniProtKB/Swiss-Prot
    P70174
    UniProtKB/TrEMBL
    B3Y5T0
    Related
    ENSMUSP00000124460.2, ENSMUST00000161650.3
    Conserved Domains (1) summary
    cd15050
    Location:29480
    7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001252643.2NP_001239572.1  histamine H1 receptor

    See identical proteins and their annotated locations for NP_001239572.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 6. Variants 1 thorugh 6 encode the same protein.
    Source sequence(s)
    AC159381, AK038480, AK046607, AK047070
    Consensus CDS
    CCDS20435.1
    UniProtKB/Swiss-Prot
    P70174
    UniProtKB/TrEMBL
    B3Y5T0
    Related
    ENSMUSP00000124037.2, ENSMUST00000161220.2
    Conserved Domains (1) summary
    cd15050
    Location:29480
    7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_001317124.1NP_001304053.1  histamine H1 receptor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 6. Variants 1 thorugh 6 encode the same protein.
    Source sequence(s)
    AC159381, AK032763, AK046607
    Consensus CDS
    CCDS20435.1
    UniProtKB/Swiss-Prot
    P70174
    UniProtKB/TrEMBL
    B3Y5T0
    Related
    ENSMUSP00000124320.2, ENSMUST00000160780.2
    Conserved Domains (1) summary
    cd15050
    Location:29480
    7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. NM_001317125.1NP_001304054.1  histamine H1 receptor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 6. Variants 1 thorugh 6 encode the same protein.
    Source sequence(s)
    AC159381, AK046607, BY269581
    Consensus CDS
    CCDS20435.1
    UniProtKB/Swiss-Prot
    P70174
    UniProtKB/TrEMBL
    B3Y5T0
    Conserved Domains (1) summary
    cd15050
    Location:29480
    7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  5. NM_001317126.1NP_001304055.1  histamine H1 receptor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) represents the longest transcript. Variants 1 thorugh 6 encode the same protein.
    Source sequence(s)
    AC159381, AK046607, BY268114, BY273302
    Consensus CDS
    CCDS20435.1
    UniProtKB/Swiss-Prot
    P70174
    UniProtKB/TrEMBL
    B3Y5T0
    Conserved Domains (1) summary
    cd15050
    Location:29480
    7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  6. NM_008285.4NP_032311.2  histamine H1 receptor

    See identical proteins and their annotated locations for NP_032311.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 6. Variants 1 through 6 encode the same protein.
    Source sequence(s)
    AC159381, AK046607
    Consensus CDS
    CCDS20435.1
    UniProtKB/Swiss-Prot
    P70174
    UniProtKB/TrEMBL
    B3Y5T0
    Related
    ENSMUSP00000086383.3, ENSMUST00000088987.3
    Conserved Domains (1) summary
    cd15050
    Location:29480
    7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    114374897..114460259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255192.2XP_030111052.1  histamine H1 receptor isoform X1

    Conserved Domains (1) summary
    cd15050
    Location:29480
    7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
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