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Hrh2 histamine receptor H2 [ Mus musculus (house mouse) ]

Gene ID: 15466, updated on 21-Apr-2024

Summary

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Official Symbol
Hrh2provided by MGI
Official Full Name
histamine receptor H2provided by MGI
Primary source
MGI:MGI:108482
See related
Ensembl:ENSMUSG00000034987 AllianceGenome:MGI:108482
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H2R; HH2R
Summary
Predicted to enable G protein-coupled amine receptor activity; heterocyclic compound binding activity; and neurotransmitter receptor activity. Acts upstream of or within several processes, including gastric acid secretion; learning or memory; and toxin transport. Predicted to be located in membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in brain; early conceptus; stomach; and uterus. Orthologous to human HRH2 (histamine receptor H2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 1.9), stomach adult (RPKM 1.8) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 B1; 13 28.4 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (54345990..54390201)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (54191970..54236182)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein, large, P0 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8891 Neighboring gene predicted gene, 34640 Neighboring gene STARR-seq mESC enhancer starr_34580 Neighboring gene predicted gene 16578 Neighboring gene predicted gene, 40955 Neighboring gene predicted gene, 48622 Neighboring gene STARR-positive B cell enhancer ABC_E5398 Neighboring gene complexin 2 Neighboring gene STARR-positive B cell enhancer ABC_E11782 Neighboring gene STARR-positive B cell enhancer ABC_E7240

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Histamine H(2) receptor deficit in glutamatergic neurons contributes to the pathogenesis of schizophrenia. Ma Q, et al. Proc Natl Acad Sci U S A, 2023 Feb 28. PMID 36812204, Free PMC Article
  2. Generation and identification of endothelial-specific Hrh2 knockout mice. Meng R, et al. Transgenic Res, 2021 Jun. PMID 33786748
  3. Histamine H2 receptor negatively regulates oligodendrocyte differentiation in neonatal hypoxic-ischemic white matter injury. Jiang L, et al. J Exp Med, 2021 Jan 4. PMID 32991666, Free PMC Article
  4. Initial Characterization of Transgenic Mice Overexpressing Human Histamine H(2) Receptors. Gergs U, et al. J Pharmacol Exp Ther, 2019 Apr. PMID 30728249
  5. Histamine receptor 2 modifies iNKT cell activity within the inflamed lung. Ferstl R, et al. Allergy, 2017 Dec. PMID 28618071

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Histamine H2 receptor deficit in glutamatergic neurons contributes to the pathogenesis of schizophrenia.
    Title: Histamine H(2) receptor deficit in glutamatergic neurons contributes to the pathogenesis of schizophrenia.
  2. Generation and identification of endothelial-specific Hrh2 knockout mice.
    Title: Generation and identification of endothelial-specific Hrh2 knockout mice.
  3. Histamine H2 receptor negatively regulates oligodendrocyte differentiation in neonatal hypoxic-ischemic white matter injury.
    Title: Histamine H2 receptor negatively regulates oligodendrocyte differentiation in neonatal hypoxic-ischemic white matter injury.
  4. These data suggest that Hrh2 signaling is required for effective phagocytosis by regulating the process of autophagy and scavenger receptor MSR1 abundance in macrophages.
    Title: Phagocytosis by macrophages depends on histamine H2 receptor signaling and scavenger receptor 1.
  5. The deliberate activation of H2 R, or its downstream signaling molecules, may represent a novel therapeutic target for chronic lung inflammatory diseases, especially when CD1d-mediated presentation of lipid antigens to iNKT cells is contributing to the pathology.
    Title: Histamine receptor 2 modifies iNKT cell activity within the inflamed lung.
  6. Ability of probiotic L. reuteri to suppress colitis depends on the presence of a bacterial histidine decarboxylase gene(s) in the intestinal microbiome, consumption of a histidine-containing diet, and signaling via the histamine H2 receptor (H2R).
    Title: Histamine H2 Receptor-Mediated Suppression of Intestinal Inflammation by Probiotic Lactobacillus reuteri.
  7. required for IL-6 and IL-17 mucosal responses to intestinal histamine-secreting microbes
    Title: Histamine receptor 2 is a key influence in immune responses to intestinal histamine-secreting microbes.
  8. histamine facilitates memory retention of inhibitory avoidance in mice, non-linearly by H2 receptor activation
    Title: Intra-cerebellar microinjection of histamine enhances memory consolidation of inhibitory avoidance learning in mice via H2 receptors.
  9. histamine receptor H1 and histamine receptor H2 reciprocally regulate inflammation in the ligation-induced arteriosclerosis
    Title: Histamine receptors expressed in circulating progenitor cells have reciprocal actions in ligation-induced arteriosclerosis.
  10. Data show that experimental allergic encephalomyelitis (EAE) severity and in histamine H2 receptor (H2RKO) mice expressing H2R exclusively in T cells become equal to those in wild-type B6 mice only when pertussis toxin is used to elicit disease.
    Title: Histamine H₂ receptor signaling × environment interactions determine susceptibility to experimental allergic encephalomyelitis.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heterocyclic compound binding ISO
Inferred from Sequence Orthology
more info
  
enables histamine receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within digestive tract development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within epithelial cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within gastric acid secretion IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within gastrin-induced gastric acid secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within gland development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within histamine-induced gastric acid secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of arachidonic acid secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within visual learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
histamine H2 receptor
Names
gastric receptor I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010973.3 → NP_001010973.1  histamine H2 receptor isoform 1

    See identical proteins and their annotated locations for NP_001010973.1

    Status: VALIDATED

    Source sequence(s)
    AC163343, AC164086
    Consensus CDS
    CCDS26526.1
    UniProtKB/Swiss-Prot
    P97292, Q9D282
    UniProtKB/TrEMBL
    Q9QX37
    Related
    ENSMUSP00000038170.4, ENSMUST00000038101.4
    Conserved Domains (1) summary
    cd15051
    Location:19 → 298
    7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001413010.1 → NP_001399939.1  histamine H2 receptor isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC163343, AC164086
    UniProtKB/TrEMBL
    A0A1B0GSX9
    Related
    ENSMUSP00000148117.2, ENSMUST00000209846.2

RNA

  1. NR_153432.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163343, AC164086
    Related
    ENSMUST00000211742.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    54345990..54390201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157857.1 → XP_036013750.1  histamine H2 receptor isoform X2

    Conserved Domains (2) summary
    cd14964
    Location:40 → 70
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:2 → 112
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_036157856.1 → XP_036013749.1  histamine H2 receptor isoform X1

    UniProtKB/TrEMBL
    A0A1B0GSX9, Q9QX37
    Conserved Domains (1) summary
    cd15051
    Location:19 → 298
    7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_008286.2: Suppressed sequence

    Description
    NM_008286.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97292.2 GenPept UniProtKB/Swiss-Prot:P97292

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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