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Prmt1 protein arginine N-methyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 15469, updated on 8-Jul-2021

Summary

Official Symbol
Prmt1provided by MGI
Official Full Name
protein arginine N-methyltransferase 1provided by MGI
Primary source
MGI:MGI:107846
See related
Ensembl:ENSMUSG00000109324
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hrmt1; Mrmt1; Hrmt1l2; AW214366; 6720434D09Rik
Expression
Ubiquitous expression in CNS E11.5 (RPKM 124.9), CNS E18 (RPKM 124.2) and 27 other tissues See more
Orthologs
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Genomic context

See Prmt1 in Genome Data Viewer
Location:
7 B3; 7 29.07 cM
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44626179..44635844, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44976755..44986420, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (52232128..52241702, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene testis-specific serine kinase substrate Neighboring gene carnitine palmitoyltransferase 1c Neighboring gene predicted gene 15545 Neighboring gene BCL2-like 12 (proline rich) Neighboring gene interferon regulatory factor 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables S-adenosyl-L-methionine binding ISO
Inferred from Sequence Orthology
more info
 
enables [cytochrome c]-arginine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables histone methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone methyltransferase activity (H4-R3 specific) ISO
Inferred from Sequence Orthology
more info
 
enables histone-arginine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables methyl-CpG binding ISO
Inferred from Sequence Orthology
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables mitogen-activated protein kinase p38 binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-arginine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-arginine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein-arginine omega-N asymmetric methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-arginine omega-N asymmetric methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-arginine omega-N monomethyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables snoRNP binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA splicing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in histone H4-R3 methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone H4-R3 methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in histone methylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of megakaryocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-arginine methylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within peptidyl-arginine methylation, to asymmetrical-dimethyl arginine ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-arginine methylation, to asymmetrical-dimethyl arginine ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peptidyl-arginine omega-N-methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hemoglobin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of megakaryocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
part_of methylosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein arginine N-methyltransferase 1
Names
arginine N-methyltransferase 1
heterogeneous nuclear ribonucleoproteins methyltransferase-like 2
histone-arginine N-methyltransferase PRMT1
NP_001239405.1
NP_001239406.1
NP_062804.1
XP_030098017.1
XP_030098018.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252476.1NP_001239405.1  protein arginine N-methyltransferase 1 isoform 2

    See identical proteins and their annotated locations for NP_001239405.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AI846916, AK152342, BU524421, BY760714
    Consensus CDS
    CCDS57547.1
    UniProtKB/Swiss-Prot
    Q9JIF0
    UniProtKB/TrEMBL
    Q3UIG8
    Related
    ENSMUSP00000147252.2, ENSMUST00000207370.2
    Conserved Domains (1) summary
    cd02440
    Location:74174
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. NM_001252477.1NP_001239406.1  protein arginine N-methyltransferase 1 isoform 3

    See identical proteins and their annotated locations for NP_001239406.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AI846916, AK020120, BU524421, W49313
    Consensus CDS
    CCDS85293.1
    UniProtKB/TrEMBL
    A0A140LJ70, Q9CX58
    Related
    ENSMUSP00000147101.2, ENSMUST00000207659.2
    Conserved Domains (1) summary
    cd02440
    Location:74140
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. NM_019830.3NP_062804.1  protein arginine N-methyltransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_062804.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
    Source sequence(s)
    AF232716, AI846916, BU524421, BY760714
    Consensus CDS
    CCDS21222.1
    UniProtKB/Swiss-Prot
    Q9JIF0
    Related
    ENSMUSP00000103474.4, ENSMUST00000107843.11
    Conserved Domains (1) summary
    cd02440
    Location:92192
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RNA

  1. NR_045521.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI846916, BC051953, BU524421

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44626179..44635844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242158.2XP_030098018.1  protein arginine N-methyltransferase 1 isoform X2

    Conserved Domains (1) summary
    cd02440
    Location:63163
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. XM_030242157.2XP_030098017.1  protein arginine N-methyltransferase 1 isoform X1

    Conserved Domains (1) summary
    cd02440
    Location:75175
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
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