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Prmt1 protein arginine N-methyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 15469, updated on 21-Apr-2024

Summary

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Official Symbol
Prmt1provided by MGI
Official Full Name
protein arginine N-methyltransferase 1provided by MGI
Primary source
MGI:MGI:107846
See related
Ensembl:ENSMUSG00000109324 AllianceGenome:MGI:107846
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mrmt1; Hrmt1l2; 6720434D09Rik
Summary
Enables histone methyltransferase activity and protein-arginine omega-N asymmetric methyltransferase activity. Involved in RNA splicing and cardiac muscle tissue development. Acts upstream of or within in utero embryonic development and peptidyl-arginine methylation, to asymmetrical-dimethyl arginine. Located in nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and lung. Orthologous to human PRMT1 (protein arginine methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 124.9), CNS E18 (RPKM 124.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B3; 7 29.07 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44626179..44635844, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44976755..44986420, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E88 Neighboring gene testis-specific serine kinase substrate Neighboring gene carnitine palmitoyltransferase 1c Neighboring gene STARR-seq mESC enhancer starr_18822 Neighboring gene predicted gene 15545 Neighboring gene BCL2 like 12 Neighboring gene interferon regulatory factor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Protein arginine methyltransferase PRMT1 promotes adipogenesis by modulating transcription factors C/EBPβ and PPARγ. Zhu Q, et al. J Biol Chem, 2022 Sep. PMID 35921899, Free PMC Article
  2. Protein Arginine Methyltransferase 1 Is Essential for the Meiosis of Male Germ Cells. Waseem S, et al. Int J Mol Sci, 2021 Jul 26. PMID 34360715, Free PMC Article
  3. Depletion of Prmt1 in Adipocytes Impairs Glucose Homeostasis in Diet-Induced Obesity. Choi S, et al. Diabetes, 2021 Aug. PMID 34039627
  4. Loss of PRMT1 in the central nervous system (CNS) induces reactive astrocytes and microglia during postnatal brain development. Hashimoto M, et al. J Neurochem, 2021 Mar. PMID 33460120
  5. A critical role for hepatic protein arginine methyltransferase 1 isoform 2 in glycemic control. Ma Y, et al. FASEB J, 2020 Nov. PMID 32918517, Free PMC Article

See all (125) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PRMT1 promotes pancreatic cancer development and resistance to chemotherapy.
    Title: PRMT1 promotes pancreatic cancer development and resistance to chemotherapy.
  2. Protein arginine methyltransferase 1 is required for the maintenance of adult small intestinal and colonic epithelial cell homeostasis.
    Title: Protein arginine methyltransferase 1 is required for the maintenance of adult small intestinal and colonic epithelial cell homeostasis.
  3. PRMT1 accelerates cell proliferation, migration, and tumor growth by upregulating ZEB1/H4R3me2as in thyroid carcinoma.
    Title: PRMT1 accelerates cell proliferation, migration, and tumor growth by upregulating ZEB1/H4R3me2as in thyroid carcinoma.
  4. The arginine methyltransferase Prmt1 coordinates the germline arginine methylome essential for spermatogonial homeostasis and male fertility.
    Title: The arginine methyltransferase Prmt1 coordinates the germline arginine methylome essential for spermatogonial homeostasis and male fertility.
  5. Inhibition of PRMT1 alleviates sepsis-induced acute kidney injury in mice by blocking the TGF-beta1 and IL-6 trans-signaling pathways.
    Title: Inhibition of PRMT1 alleviates sepsis-induced acute kidney injury in mice by blocking the TGF-β1 and IL-6 trans-signaling pathways.
  6. PRMT1-mediated arginine methylation promotes postnatal calvaria bone formation through BMP-Smad signaling.
    Title: PRMT1-mediated arginine methylation promotes postnatal calvaria bone formation through BMP-Smad signaling.
  7. PRMT1 reverts the immune escape of necroptotic colon cancer through RIP3 methylation.
    Title: PRMT1 reverts the immune escape of necroptotic colon cancer through RIP3 methylation.
  8. Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice.
    Title: Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice.
  9. PRMT1 mediated methylation of cGAS suppresses anti-tumor immunity.
    Title: PRMT1 mediated methylation of cGAS suppresses anti-tumor immunity.
  10. Protein arginine methyltransferase PRMT1 promotes adipogenesis by modulating transcription factors C/EBPbeta and PPARgamma.
    Title: Protein arginine methyltransferase PRMT1 promotes adipogenesis by modulating transcription factors C/EBPβ and PPARγ.
Submit: New GeneRIF Correction See all GeneRIFs (72)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GATOR1 complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables S-adenosyl-L-methionine binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H4R3 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables methyl-CpG binding ISO
Inferred from Sequence Orthology
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mitogen-activated protein kinase p38 binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-arginine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-arginine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein-arginine omega-N asymmetric methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-arginine omega-N asymmetric methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-arginine omega-N asymmetric methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-arginine omega-N monomethyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-arginine omega-N monomethyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables snoRNP binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cardiac muscle tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to methionine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of megakaryocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-arginine methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within peptidyl-arginine methylation, to asymmetrical-dimethyl arginine ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within peptidyl-arginine omega-N-methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of megakaryocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of methylosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein arginine N-methyltransferase 1
Names
arginine N-methyltransferase 1
heterogeneous nuclear ribonucleoproteins methyltransferase-like 2
histone-arginine N-methyltransferase PRMT1
NP_001239405.1
NP_001239406.1
NP_062804.1
XP_030098017.1
XP_030098018.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252476.1 → NP_001239405.1  protein arginine N-methyltransferase 1 isoform 2

    See identical proteins and their annotated locations for NP_001239405.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AI846916, AK152342, BU524421, BY760714
    Consensus CDS
    CCDS57547.1
    UniProtKB/TrEMBL
    F8WH01, Q3UIG8, Q80WB1
    Related
    ENSMUSP00000147252.2, ENSMUST00000207370.2
    Conserved Domains (1) summary
    cd02440
    Location:74 → 174
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. NM_001252477.1 → NP_001239406.1  protein arginine N-methyltransferase 1 isoform 3

    See identical proteins and their annotated locations for NP_001239406.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AI846916, AK020120, BU524421, W49313
    Consensus CDS
    CCDS85293.1
    UniProtKB/TrEMBL
    A0A140LJ70, Q9CX58
    Related
    ENSMUSP00000147101.2, ENSMUST00000207659.2
    Conserved Domains (1) summary
    cd02440
    Location:74 → 140
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  3. NM_019830.3 → NP_062804.1  protein arginine N-methyltransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_062804.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
    Source sequence(s)
    AF232716, AI846916, BU524421, BY760714
    Consensus CDS
    CCDS21222.1
    UniProtKB/Swiss-Prot
    Q99LS4, Q9JIF0
    UniProtKB/TrEMBL
    Q8C2D7
    Related
    ENSMUSP00000103474.4, ENSMUST00000107843.11
    Conserved Domains (1) summary
    cd02440
    Location:92 → 192
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RNA

  1. NR_045521.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI846916, BC051953, BU524421

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44626179..44635844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242158.2 → XP_030098018.1  protein arginine N-methyltransferase 1 isoform X2

    UniProtKB/TrEMBL
    Q8C2D7
    Conserved Domains (1) summary
    cd02440
    Location:63 → 163
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. XM_030242157.2 → XP_030098017.1  protein arginine N-methyltransferase 1 isoform X1

    UniProtKB/TrEMBL
    Q80WV6, Q8C2D7
    Conserved Domains (1) summary
    cd02440
    Location:75 → 175
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JIF0.1 GenPept UniProtKB/Swiss-Prot:Q9JIF0

Gene LinkOut

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