Format

Send to:

Choose Destination

Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 [ Mus musculus (house mouse) ]

Gene ID: 15483, updated on 5-Sep-2021

Summary

Official Symbol
Hsd11b1provided by MGI
Official Full Name
hydroxysteroid 11-beta dehydrogenase 1provided by MGI
Primary source
MGI:MGI:103562
See related
Ensembl:ENSMUSG00000016194
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Biased expression in liver adult (RPKM 236.8), lung adult (RPKM 66.7) and 8 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Hsd11b1 in Genome Data Viewer
Location:
1; 1 H6
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (192903948..192946353, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (193221640..193264045, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (195047834..195090239, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A130010J15 gene Neighboring gene interferon regulatory factor 6 Neighboring gene TRAF3 interacting protein 3 Neighboring gene G0/G1 switch gene 2 Neighboring gene laminin, beta 3 Neighboring gene predicted gene, 51741

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
 
enables 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NADP binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables steroid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables steroid binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in glucocorticoid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glucocorticoid catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mineralocorticoid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of pentose-phosphate shunt ISO
Inferred from Sequence Orthology
more info
 
involved_in steroid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
corticosteroid 11-beta-dehydrogenase isozyme 1
Names
11-DH
11-beta-HSD1
11-beta-hydroxysteroid dehydrogenase 1
11beta-HSD-1
11beta-HSD1A
11beta-hydroxysteroid dehydrogenase type 1
Corticosteroid 11-beta-dehydrogenase, isozyme 1 (11-DH) (11-beta-hydroxysteroid dehydrogenase 1) (11-beta-HSD1) (11beta-HSD1A)
NP_001038216.1
NP_032314.2
XP_006497291.1
XP_030105692.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044751.1NP_001038216.1  corticosteroid 11-beta-dehydrogenase isozyme 1

    See identical proteins and their annotated locations for NP_001038216.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein. An in-frame AUG is located 41 codons upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context.
    Source sequence(s)
    AI099306, AI132676, AK149518
    Consensus CDS
    CCDS15635.1
    UniProtKB/Swiss-Prot
    P50172
    UniProtKB/TrEMBL
    Q4JHD9
    Related
    ENSMUSP00000016338.9, ENSMUST00000016338.15
    Conserved Domains (1) summary
    cd05332
    Location:32279
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
  2. NM_008288.2NP_032314.2  corticosteroid 11-beta-dehydrogenase isozyme 1

    See identical proteins and their annotated locations for NP_032314.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein. An in-frame AUG is located 41 codons upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context.
    Source sequence(s)
    AI132676, AI182353, DQ089001
    Consensus CDS
    CCDS15635.1
    UniProtKB/Swiss-Prot
    P50172
    UniProtKB/TrEMBL
    Q4JHD9
    Related
    ENSMUSP00000125620.2, ENSMUST00000161737.8
    Conserved Domains (1) summary
    cd05332
    Location:32279
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    192903948..192946353 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249832.1XP_030105692.1  corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X2

    Conserved Domains (1) summary
    cd05332
    Location:32279
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
  2. XM_006497228.3XP_006497291.1  corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1

    Conserved Domains (1) summary
    cd05332
    Location:44291
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
Support Center