Format

Send to:

Choose Destination

Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 [ Mus musculus (house mouse) ]

Gene ID: 15487, updated on 5-Jan-2022

Summary

Official Symbol
Hsd17b3provided by MGI
Official Full Name
hydroxysteroid (17-beta) dehydrogenase 3provided by MGI
Primary source
MGI:MGI:107177
See related
Ensembl:ENSMUSG00000033122
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable estradiol 17-beta-dehydrogenase activity; testosterone 17-beta-dehydrogenase (NADP+) activity; and testosterone dehydrogenase (NAD+) activity. Predicted to be involved in steroid biosynthetic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in endoplasmic reticulum. Is expressed in testis. Used to study pseudohermaphroditism. Human ortholog(s) of this gene implicated in 17-beta hydroxysteroid dehydrogenase 3 deficiency and disorder of sexual development. Orthologous to human HSD17B3 (hydroxysteroid 17-beta dehydrogenase 3). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Restricted expression toward testis adult (RPKM 6.2) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Hsd17b3 in Genome Data Viewer
Location:
13; 13 B3
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (64206088..64237076, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (64058274..64089262, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (64159582..64190509, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L10A pseudogene Neighboring gene predicted gene, 30999 Neighboring gene solute carrier family 35, member D2 Neighboring gene zinc finger protein 367

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables estradiol 17-beta-dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables testosterone 17-beta-dehydrogenase (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables testosterone 17-beta-dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
 
enables testosterone dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in male genitalia development IEA
Inferred from Electronic Annotation
more info
 
involved_in steroid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in testosterone biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
testosterone 17-beta-dehydrogenase 3
Names
17(beta)HSD type 3
17-beta-HSD 3
17-beta-hydroxysteroid dehydrogenase type 3
estradiol 17-beta-dehydrogenase 2
testicular 17-beta-hydroxysteroid dehydrogenase
NP_032317.2
XP_006517171.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008291.3NP_032317.2  testosterone 17-beta-dehydrogenase 3

    See identical proteins and their annotated locations for NP_032317.2

    Status: VALIDATED

    Source sequence(s)
    BB041573, BB621153, U66827
    Consensus CDS
    CCDS26594.1
    UniProtKB/Swiss-Prot
    P70385
    Related
    ENSMUSP00000132011.2, ENSMUST00000166224.8
    Conserved Domains (2) summary
    cd05356
    Location:44280
    17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
    pfam00106
    Location:45236
    adh_short; short chain dehydrogenase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    64206088..64237076 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517108.3XP_006517171.1  testosterone 17-beta-dehydrogenase 3 isoform X1

    Conserved Domains (1) summary
    cd05356
    Location:86268
    17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
Support Center