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Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 [ Mus musculus (house mouse) ]

Gene ID: 15487, updated on 5-Mar-2024

Summary

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Official Symbol
Hsd17b3provided by MGI
Official Full Name
hydroxysteroid (17-beta) dehydrogenase 3provided by MGI
Primary source
MGI:MGI:107177
See related
Ensembl:ENSMUSG00000033122 AllianceGenome:MGI:107177
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable estradiol 17-beta-dehydrogenase activity; testosterone 17-beta-dehydrogenase (NADP+) activity; and testosterone dehydrogenase (NAD+) activity. Predicted to be involved in steroid biosynthetic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in endoplasmic reticulum. Is expressed in testis. Used to study pseudohermaphroditism. Human ortholog(s) of this gene implicated in 17-beta hydroxysteroid dehydrogenase 3 deficiency and disorder of sexual development. Orthologous to human HSD17B3 (hydroxysteroid 17-beta dehydrogenase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 6.2) See more
Orthologs
human all
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Genomic context

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See Hsd17b3 in Genome Data Viewer
Location:
13 B3; 13 33.26 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (64206088..64237076, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (64058274..64089262, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L10A pseudogene Neighboring gene STARR-seq mESC enhancer starr_34813 Neighboring gene STARR-seq mESC enhancer starr_34816 Neighboring gene STARR-seq mESC enhancer starr_34817 Neighboring gene STARR-seq mESC enhancer starr_34818 Neighboring gene predicted gene, 30999 Neighboring gene solute carrier family 35, member D2 Neighboring gene STARR-seq mESC enhancer starr_34820 Neighboring gene STARR-positive B cell enhancer ABC_E5404 Neighboring gene zinc finger protein 367

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ablation of the canonical testosterone production pathway via knockout of the steroidogenic enzyme HSD17B3, reveals a novel mechanism of testicular testosterone production. Rebourcet D, et al. FASEB J, 2020 Aug. PMID 32557858, Free PMC Article
  2. The lack of HSD17B3 in male mice results in disturbed Leydig cell maturation and endocrine imbalance akin to humans with HSD17B3 deficiency. Sipilä P, et al. FASEB J, 2020 May. PMID 32190925
  3. [Effects of infrasound on activities of 3beta hydroxysteroid dehydrogenase and acid phosphatase of polygonal cells in adrenal cortex zona fasciculate in mice]. Dang WM, et al. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, 2007 Feb. PMID 17456400
  4. Targeted placental deletion of OGT recapitulates the prenatal stress phenotype including hypothalamic mitochondrial dysfunction. Howerton CL, et al. Proc Natl Acad Sci U S A, 2014 Jul 1. PMID 24979775, Free PMC Article
  5. Contribution of Leydig and Sertoli cells to testosterone production in mouse fetal testes. Shima Y, et al. Mol Endocrinol, 2013 Jan. PMID 23125070, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ablation of the canonical testosterone production pathway via knockout of the steroidogenic enzyme HSD17B3, reveals a novel mechanism of testicular testosterone production.
    Title: Ablation of the canonical testosterone production pathway via knockout of the steroidogenic enzyme HSD17B3, reveals a novel mechanism of testicular testosterone production.
  2. The lack of HSD17B3 in male mice results in disturbed Leydig cell maturation and endocrine imbalance akin to humans with HSD17B3 deficiency.
    Title: The lack of HSD17B3 in male mice results in disturbed Leydig cell maturation and endocrine imbalance akin to humans with HSD17B3 deficiency.
  3. Enzyme activities of 3-betaHSDH increase as the sound pressure levels increase in adrenal cortex zona fasciculate polygonal cells.
    Title: [Effects of infrasound on activities of 3beta hydroxysteroid dehydrogenase and acid phosphatase of polygonal cells in adrenal cortex zona fasciculate in mice].
  4. High 4-tert-Octylphenol doses affect the cytoarchitecture of MA-10 Leydig cells as well as attenuate 3beta-HSD and AR expression.
    Title: Octylphenol affects morphology and steroidogenesis in mouse tumor Leydig cells.
  5. Pubertal Cd exposure markedly reduced mRNA and protein levels of testicular StAR, P450scc, P450(17alpha) and 17beta-HSD in mice.
    Title: Pubertal cadmium exposure impairs testicular development and spermatogenesis via disrupting testicular testosterone synthesis in adult mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables testosterone 17-beta-dehydrogenase (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables testosterone 17-beta-dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
  
enables testosterone dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in steroid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
17-beta-hydroxysteroid dehydrogenase type 3
Names
17(beta)HSD type 3
17-beta-HSD 3
estradiol 17-beta-dehydrogenase 2
testicular 17-beta-hydroxysteroid dehydrogenase
testosterone 17-beta-dehydrogenase 3
NP_032317.2
XP_006517171.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008291.3 → NP_032317.2  17-beta-hydroxysteroid dehydrogenase type 3

    See identical proteins and their annotated locations for NP_032317.2

    Status: VALIDATED

    Source sequence(s)
    BB041573, BB621153, U66827
    Consensus CDS
    CCDS26594.1
    UniProtKB/Swiss-Prot
    G3UWF9, P70385
    Related
    ENSMUSP00000132011.2, ENSMUST00000166224.8
    Conserved Domains (2) summary
    cd05356
    Location:44 → 280
    17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
    pfam00106
    Location:45 → 236
    adh_short; short chain dehydrogenase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    64206088..64237076 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517108.3 → XP_006517171.1  17-beta-hydroxysteroid dehydrogenase type 3 isoform X1

    Conserved Domains (1) summary
    cd05356
    Location:86 → 268
    17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70385.2 GenPept UniProtKB/Swiss-Prot:P70385

Gene LinkOut

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