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Hsd3b6 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 [ Mus musculus (house mouse) ]

Gene ID: 15497, updated on 5-Jan-2022

Summary

Official Symbol
Hsd3b6provided by MGI
Official Full Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6provided by MGI
Primary source
MGI:MGI:109598
See related
Ensembl:ENSMUSG00000027869
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D19210
Summary
Predicted to enable 3-beta-hydroxy-delta5-steroid dehydrogenase activity and steroid delta-isomerase activity. Predicted to be involved in several processes, including hippocampus development; response to corticosterone; and steroid hormone biosynthetic process. Predicted to be located in several cellular components, including intercellular bridge; mitochondrial envelope; and nucleolus. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in several structures, including alimentary system; brain; cardiovascular system; extraembryonic component; and genitourinary system. Human ortholog(s) of this gene implicated in hypertension and hypospadias. Orthologous to human HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) and HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in testis adult (RPKM 30.9), liver E18 (RPKM 22.0) and 8 other tissues See more
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Genomic context

See Hsd3b6 in Genome Data Viewer
Location:
3; 3 F2.2
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (98712820..98721759, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (98805504..98814443, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (98609427..98618366, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 Neighboring gene 14-3-3 protein eta pseudogene Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-beta-hydroxy-delta5-steroid dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables cholesterol dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables steroid delta-isomerase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in C21-steroid hormone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in C21-steroid hormone metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in androgen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in hippocampus development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of iron ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in response to corticosterone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in steroid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 6
Names
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type VI
3-beta-HSD VI
3beta-HSD VI
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 pseudogene
hydroxysteroid dehydrogenase-6, delta<5>-3-beta
NP_038849.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013821.3NP_038849.2  3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 6

    See identical proteins and their annotated locations for NP_038849.2

    Status: VALIDATED

    Source sequence(s)
    AK142267, BC053501
    Consensus CDS
    CCDS17669.1
    UniProtKB/Swiss-Prot
    O35469
    UniProtKB/TrEMBL
    Q7TPU0
    Related
    ENSMUSP00000029463.7, ENSMUST00000029463.13
    Conserved Domains (2) summary
    pfam01073
    Location:7287
    3Beta_HSD; 3-beta hydroxysteroid dehydrogenase/isomerase family
    cl21454
    Location:5357
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    98712820..98721759 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_017291.1: Suppressed sequence

    Description
    NG_017291.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
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