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Hsph1 heat shock 105kDa/110kDa protein 1 [ Mus musculus (house mouse) ]

Gene ID: 15505, updated on 5-Mar-2024

Summary

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Official Symbol
Hsph1provided by MGI
Official Full Name
heat shock 105kDa/110kDa protein 1provided by MGI
Primary source
MGI:MGI:105053
See related
Ensembl:ENSMUSG00000029657 AllianceGenome:MGI:105053
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
105kDa; Hsp105; Hsp110; hsp-E7I; hsp110/105
Summary
Enables alpha-tubulin binding activity. Acts upstream of or within several processes, including chaperone cofactor-dependent protein refolding; negative regulation of intracellular signal transduction; and positive regulation of nitrogen compound metabolic process. Located in cytoplasm and nucleus. Colocalizes with microtubule. Is expressed in several structures, including brain; gut; integumental system; liver and biliary system; and reproductive system. Orthologous to human HSPH1 (heat shock protein family H (Hsp110) member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 30.2), CNS E11.5 (RPKM 29.9) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Hsph1 in Genome Data Viewer
Location:
5 G3; 5 89.18 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (149540308..149562594, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (149616843..149636498, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15997 Neighboring gene WD40 repeat domain 95 Neighboring gene predicted gene, 54316 Neighboring gene STARR-seq mESC enhancer starr_14938 Neighboring gene predicted gene, 35763 Neighboring gene STARR-positive B cell enhancer ABC_E3638 Neighboring gene STARR-positive B cell enhancer ABC_E1317 Neighboring gene STARR-seq mESC enhancer starr_14940 Neighboring gene predicted gene, 20005 Neighboring gene NME/NM23 nucleoside diphosphate kinase, pseudogene 1 Neighboring gene beta-3-glucosyltransferase Neighboring gene STARR-seq mESC enhancer starr_14941 Neighboring gene predicted gene, 36141

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Knockdown of HSP110 attenuates hypoxia-induced pulmonary hypertension in mice through suppression of YAP/TAZ-TEAD4 pathway. Liu H, et al. Respir Res, 2022 Aug 19. PMID 35986277, Free PMC Article
  2. Hsp105α suppresses Adriamycin-induced cell death via nuclear localization signal-dependent nuclear accumulation. Yamane T, et al. J Cell Biochem, 2019 Oct. PMID 31173393
  3. Characterization of stress sensitivity and chaperone activity of Hsp105 in mammalian cells. Yamagishi N, et al. Biochem Biophys Res Commun, 2011 May 27. PMID 21557931
  4. Targeted disruption of Hsp110/105 gene protects against ischemic stress. Nakamura J, et al. Stroke, 2008 Oct. PMID 18658041
  5. Synthetic small interfering RNA targeting heat shock protein 105 induces apoptosis of various cancer cells both in vitro and in vivo. Hosaka S, et al. Cancer Sci, 2006 Jul. PMID 16827803

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of HSP110 attenuates hypoxia-induced pulmonary hypertension in mice through suppression of YAP/TAZ-TEAD4 pathway.
    Title: Knockdown of HSP110 attenuates hypoxia-induced pulmonary hypertension in mice through suppression of YAP/TAZ-TEAD4 pathway.
  2. Hsp105alpha suppresses Adriamycin-induced cell death via nuclear localization signal-dependent nuclear accumulation.
    Title: Hsp105α suppresses Adriamycin-induced cell death via nuclear localization signal-dependent nuclear accumulation.
  3. These observations suggest that GGA administration is a therapeutic candidate for depressive diseases by increasing hippocampal BDNF levels via HSP105 expression.
    Title: HSP105 prevents depression-like behavior by increasing hippocampal brain-derived neurotrophic factor levels in mice.
  4. Hsp105 may play an important role in the refolding of denatured proteins and protection against stress-induced cell death in mammalian cells.
    Title: Characterization of stress sensitivity and chaperone activity of Hsp105 in mammalian cells.
  5. hsp110/105 KO mice are resistant to ischemic injury and that the protective effects of hsp110/105 deficiency in cerebral ischemia may partly be mediated by an increase in the chaperone activity of Hsp70.
    Title: Targeted disruption of Hsp110/105 gene protects against ischemic stress.
  6. HSP105 appears to chaperone the responses to endoplasmic reticulum (ER) stress through its interactions with GRP78 and GSK3, and without HSP105 cell death following ER stress proceeds by a non-caspase-3-dependent process.
    Title: HSP105 interacts with GRP78 and GSK3 and promotes ER stress-induced caspase-3 activation.
  7. Data suggest that Hsp105 has opposite effects on stress-induced apoptosis depending on the cell type; a pro-apoptotic effect in embryonal cells and an anti-apoptotic effect in neuronal cells.
    Title: Hsp105alpha enhances stress-induced apoptosis but not necrosis in mouse embryonal f9 cells.
  8. The constitutive overexpression of HSP105 in cancer cells is involved in malignant transformation by protecting tumor cells from apoptosis.
    Title: Synthetic small interfering RNA targeting heat shock protein 105 induces apoptosis of various cancer cells both in vitro and in vivo.
  9. Hsp110 over-expression increases the immunogenicity of the murine CT26 colon tumor.
    Title: Hsp110 over-expression increases the immunogenicity of the murine CT26 colon tumor.
  10. enhances activation of p38, release of cytochrome c and caspase activation; may play important roles in organogenesis, during which marked apoptosis occurs, by enhancing apoptosis during mouse embryogenesis
    Title: Enhancement of oxidative stress-induced apoptosis by Hsp105alpha in mouse embryonal F9 cells.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables adenyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables alpha-tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within chaperone cofactor-dependent protein refolding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of neuron apoptotic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of MHC class I biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of NK T cell activation TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of microtubule cytoskeleton organization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in response to unfolded protein TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
 PubMed 
colocalizes_with microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
heat shock protein 105 kDa
Names
42 degrees C-HSP
HSP105 42 C-HSP
heat shock 110 kDa protein
heat shock protein 110
heat shock-related 100 kDa protein E7I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347534.1 → NP_001334463.1  heat shock protein 105 kDa isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC119856
    Consensus CDS
    CCDS85010.1
    UniProtKB/TrEMBL
    E9Q0U7
    Related
    ENSMUSP00000074392.9, ENSMUST00000074846.14

  2. NM_013559.2 → NP_038587.2  heat shock protein 105 kDa isoform 1

    See identical proteins and their annotated locations for NP_038587.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK146697, AK165046, AK172913, CF164049
    Consensus CDS
    CCDS19885.1
    UniProtKB/Swiss-Prot
    Q3TNS2, Q3UIY8, Q61699, Q62578, Q62579, Q6A0A5, Q8C430, Q8VCW6
    UniProtKB/TrEMBL
    E9Q0U7
    Related
    ENSMUSP00000144413.2, ENSMUST00000202361.4
    Conserved Domains (3) summary
    cd11739
    Location:2 → 384
    HSPH1_NBD; Nucleotide-binding domain of HSPH1
    pfam00012
    Location:3 → 709
    HSP70; Hsp70 protein
    pfam13552
    Location:660 → 742
    DUF4127; Protein of unknown function (DUF4127)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    149540308..149562594 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504916.4 → XP_006504979.1  heat shock protein 105 kDa isoform X2

    UniProtKB/TrEMBL
    E9Q0U7
    Conserved Domains (3) summary
    COG3087
    Location:537 → 620
    FtsN; Cell division protein FtsN [Cell cycle control, cell division, chromosome partitioning]
    pfam13552
    Location:673 → 761
    DUF4127; Protein of unknown function (DUF4127)
    cl17037
    Location:56 → 403
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  2. XM_030254168.2 → XP_030110028.1  heat shock protein 105 kDa isoform X1

    UniProtKB/TrEMBL
    E9Q0U7
    Conserved Domains (3) summary
    COG3087
    Location:425 → 508
    FtsN; Cell division protein FtsN [Cell cycle control, cell division, chromosome partitioning]
    pfam13552
    Location:561 → 649
    DUF4127; Protein of unknown function (DUF4127)
    cl17037
    Location:1 → 291
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61699.2 GenPept UniProtKB/Swiss-Prot:Q61699

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