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vpr Vpr [ Human immunodeficiency virus 1 ]

Gene ID: 155807, updated on 8-Sep-2019

Summary

Gene symbol
vpr
Gene description
Vpr
Locus tag
HIV1gp4
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Human immunodeficiency virus 1 (gb-acronym: HIV-1)
Lineage
Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; Lentivirus; Primate lentivirus group

Genomic context

Sequence:
NC_001802.1 (5105..5396)

NC_001802.1Genomic Context describing neighboring genes Neighboring gene Gag-Pol Neighboring gene Pr55(Gag) Neighboring gene Vif Neighboring gene Tat Neighboring gene Rev Neighboring gene Vpu Neighboring gene Envelope surface glycoprotein gp160, precursor Neighboring gene Asp

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
ATP-binding cassette sub-family A member 5 ABCA5 interacts with PubMed
ATP-binding cassette sub-family D member 3 isoform a ABCD3 interacts with PubMed
3-ketoacyl-CoA thiolase, mitochondrial ACAA2 enhances PubMed
acetyl-CoA acetyltransferase, mitochondrial precursor ACAT1 downregulates PubMed
Golgi resident protein GCP60 ACBD3 downregulates PubMed
acyl-CoA-binding domain-containing protein 5 isoform 1 ACBD5 interacts with PubMed
long-chain-fatty-acid--CoA ligase 4 isoform 1 ACSL4 upregulates PubMed
actin, aortic smooth muscle ACTA2 downregulates PubMed
actin, cytoplasmic 1 ACTB downregulates PubMed
beta-actin-like protein 2 ACTBL2 downregulates PubMed
actin, cytoplasmic 2 ACTG1 downregulates PubMed
ACTG1 enhances polymerization of PubMed
alpha-actinin-1 isoform a ACTN1 upregulates PubMed
alpha-actinin-4 isoform 1 ACTN4 upregulates PubMed
alkyldihydroxyacetonephosphate synthase, peroxisomal precursor AGPS interacts with PubMed
aryl hydrocarbon receptor AHR regulated by PubMed
AHR cooperates with PubMed
single-stranded DNA cytosine deaminase isoform 1 AICDA co-localizes with PubMed
AICDA inhibits PubMed
AICDA interacts with PubMed
apoptosis-inducing factor 1, mitochondrial isoform AIF precursor AIFM1 downregulates PubMed
AIFM1 interacts with PubMed
adenylate kinase 2, mitochondrial isoform a AK2 downregulates PubMed
RAC-alpha serine/threonine-protein kinase AKT1 involves PubMed
AKT1 involves PubMed
AKT1 decreases phosphorylation of PubMed
AKT1 inhibits PubMed
RAC-beta serine/threonine-protein kinase isoform 1 AKT2 regulated by PubMed
AKT2 involves PubMed
AKT2 involves PubMed
AKT2 decreases phosphorylation of PubMed
AKT2 inhibits PubMed
RAC-gamma serine/threonine-protein kinase isoform 1 AKT3 regulated by PubMed
AKT3 inhibits PubMed
fructose-bisphosphate aldolase A isoform 1 ALDOA downregulates PubMed
fructose-bisphosphate aldolase C ALDOC downregulates PubMed
ankyrin repeat and KH domain-containing protein 1 isoform 1 ANKHD1 interacts with PubMed
ankyrin repeat domain-containing protein 13A ANKRD13A interacts with PubMed
ankyrin repeat domain-containing protein 17 isoform a ANKRD17 interacts with PubMed
anillin isoform 1 ANLN upregulates PubMed
annexin A3 ANXA3 downregulates PubMed
DNA dC->dU-editing enzyme APOBEC-3A isoform b APOBEC3A upregulates PubMed
DNA dC->dU-editing enzyme APOBEC-3C APOBEC3C upregulates PubMed
DNA dC->dU-editing enzyme APOBEC-3G isoform 1 APOBEC3G induces ubiquitination of PubMed
APOBEC3G degrades PubMed
APOBEC3G upregulates PubMed
apolipoprotein E isoform b precursor APOE upregulates PubMed
arginase-2, mitochondrial precursor ARG2 downregulates PubMed
rho GDP-dissociation inhibitor 1 isoform a ARHGDIA upregulates PubMed
rho GDP-dissociation inhibitor 2 ARHGDIB modulates PubMed
acid ceramidase isoform b ASAH1 upregulates PubMed
cyclic AMP-dependent transcription factor ATF-1 ATF1 activates PubMed
ATF1 activates PubMed
serine-protein kinase ATM isoform a ATM activates PubMed
ATP synthase subunit alpha, mitochondrial isoform a precursor ATP5F1A downregulates PubMed
ATP synthase subunit beta, mitochondrial precursor ATP5F1B downregulates PubMed
ATP synthase subunit delta, mitochondrial precursor ATP5F1D downregulates PubMed
ATP synthase F(0) complex subunit B1, mitochondrial precursor ATP5PB downregulates PubMed
V-type proton ATPase subunit B, brain isoform ATP6V1B2 upregulates PubMed
serine/threonine-protein kinase ATR isoform 1 ATR activates PubMed
ATR activates PubMed
ATR interacts with PubMed
ATR activates PubMed
ATR activates PubMed
ATR interacts with PubMed
ATR activates PubMed
ATR interacts with PubMed
aurora kinase A AURKA upregulates PubMed
aurora kinase B isoform 1 AURKB upregulates PubMed
AURKB downregulates PubMed
tyrosine-protein kinase receptor UFO isoform 3 AXL upregulates PubMed
apoptosis regulator BAX isoform beta BAX dependent on PubMed
BAX upregulates PubMed
BAX mediated by PubMed
BAX upregulates PubMed
BAX downregulates PubMed
BAX enhanced by PubMed
B-cell lymphoma/leukemia 11B isoform 2 BCL11B inhibited by PubMed
apoptosis regulator Bcl-2 isoform alpha BCL2 downregulates PubMed
BCL2 upregulates PubMed
BCL2 inhibited by PubMed
bcl-2-like protein 1 isoform Bcl-X(L) BCL2L1 interacts with PubMed
BCL2L1 downregulates PubMed
BCL2L1 relocalizes PubMed
BCL2L1 downregulates PubMed
BH3-interacting domain death agonist isoform 2 BID dependent on PubMed
BID induces cleavage of PubMed
BID induces cleavage of PubMed
BID upregulates PubMed
baculoviral IAP repeat-containing protein 2 isoform 1 BIRC2 inhibited by PubMed
baculoviral IAP repeat-containing protein 3 BIRC3 counteracted by PubMed
BIRC3 inhibited by PubMed
baculoviral IAP repeat-containing protein 5 isoform 1 BIRC5 upregulates PubMed
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 BNIP3 downregulates PubMed
BNIP3 upregulates PubMed
breast cancer type 1 susceptibility protein isoform 1 BRCA1 stimulates PubMed
BRCA1 induces phosphorylation of PubMed
BRCA1 relocalizes PubMed
bone marrow stromal antigen 2 precursor BST2 downregulates PubMed
complement component 1 Q subcomponent-binding protein, mitochondrial precursor C1QBP downregulates PubMed
C3a anaphylatoxin chemotactic receptor C3AR1 upregulates PubMed
C5a anaphylatoxin chemotactic receptor 1 C5AR1 upregulates PubMed
calreticulin precursor CALR upregulates PubMed
macrophage-capping protein isoform 1 CAPG downregulates PubMed
F-actin-capping protein subunit alpha-1 CAPZA1 upregulates PubMed
caspase-1 isoform alpha precursor CASP1 activates PubMed
caspase-3 isoform a preproprotein CASP3 activates PubMed
CASP3 activates PubMed
CASP3 cooperates with PubMed
CASP3 regulated by PubMed
CASP3 activates PubMed
CASP3 induces cleavage of PubMed
CASP3 activates PubMed
CASP3 activates PubMed
CASP3 activates PubMed
CASP3 activates PubMed
CASP3 activates PubMed
caspase-6 isoform alpha precursor CASP6 activates PubMed
CASP6 upregulates PubMed
caspase-7 isoform alpha precursor CASP7 activates PubMed
CASP7 activates PubMed
CASP7 activates PubMed
CASP7 upregulates PubMed
caspase-8 isoform A precursor CASP8 dependent on PubMed
CASP8 activates PubMed
CASP8 activates PubMed
CASP8-associated protein 2 CASP8AP2 upregulates PubMed
caspase-9 isoform alpha precursor CASP9 activates PubMed
CASP9 activates PubMed
CASP9 activates PubMed
CASP9 activates PubMed
CASP9 activates PubMed
CASP9 activates PubMed
caveolin-1 isoform alpha CAV1 mediated by PubMed
chromobox protein homolog 3 CBX3 relocalizes PubMed
chromobox protein homolog 5 CBX5 relocalizes PubMed
CBX5 relocalizes PubMed
cell cycle and apoptosis regulator protein 2 isoform 1 CCAR2 downregulates PubMed
coiled-coil domain-containing protein 47 precursor CCDC47 interacts with PubMed
C-C motif chemokine 1 precursor CCL1 downregulates PubMed
C-C motif chemokine 2 precursor CCL2 upregulates PubMed
C-C motif chemokine 20 isoform 2 precursor CCL20 downregulates PubMed
C-C motif chemokine 23 isoform CKbeta8-1 precursor CCL23 upregulates PubMed
C-C motif chemokine 26 precursor CCL26 upregulates PubMed
C-C motif chemokine 3 precursor CCL3 downregulates PubMed
C-C motif chemokine 3-like 1 precursor CCL3L3 upregulates PubMed
C-C motif chemokine 4 precursor CCL4 downregulates PubMed
C-C motif chemokine 5 isoform 1 precursor CCL5 upregulates PubMed
CCL5 upregulates PubMed
CCL5 upregulates PubMed
CCL5 regulates PubMed
C-C motif chemokine 8 precursor CCL8 upregulates PubMed
G2/mitotic-specific cyclin-B1 isoform 1 CCNB1 upregulates PubMed
CCNB1 induces accumulation of PubMed
CCNB1 interacts with PubMed
CCNB1 interacts with PubMed
CCNB1 induces release of PubMed
CCNB1 inactivates PubMed
CCNB1 inhibits PubMed
CCNB1 inactivates PubMed
CCNB1 inactivates PubMed
CCNB1 inactivates PubMed
CCNB1 inactivates PubMed
G2/mitotic-specific cyclin-B2 CCNB2 inactivates PubMed
CCNB2 inhibits PubMed
CCNB2 inactivates PubMed
CCNB2 inactivates PubMed
CCNB2 inactivates PubMed
CCNB2 inactivates PubMed
G2/mitotic-specific cyclin-B3 isoform 3 CCNB3 inactivates PubMed
CCNB3 inhibits PubMed
CCNB3 inactivates PubMed
CCNB3 inactivates PubMed
CCNB3 inactivates PubMed
CCNB3 inactivates PubMed
cyclin-H isoform 1 CCNH inhibited by PubMed
CCNH enhanced by PubMed
cyclin-T1 isoform a CCNT1 binds PubMed
C-C chemokine receptor type 5 CCR5 interacts with PubMed
T-cell surface glycoprotein CD1a isoform 2 CD1A upregulates PubMed
antigen-presenting glycoprotein CD1d isoform 2 precursor CD1D downregulates PubMed
T-cell-specific surface glycoprotein CD28 isoform 1 precursor CD28 downregulates PubMed
myeloid cell surface antigen CD33 isoform 1 precursor CD33 downregulates PubMed
T-cell surface glycoprotein CD3 epsilon chain precursor CD3E antagonizes PubMed
T-cell surface glycoprotein CD4 isoform 1 precursor CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
tumor necrosis factor receptor superfamily member 5 isoform 1 precursor CD40 downregulates PubMed
CD44 antigen isoform 1 precursor CD44 upregulates PubMed
CD44 downregulates PubMed
early activation antigen CD69 CD69 activates PubMed
T-lymphocyte activation antigen CD80 precursor CD80 downregulates PubMed
CD80 downregulates PubMed
CD83 antigen isoform a precursor CD83 downregulates PubMed
CD83 downregulates PubMed
T-lymphocyte activation antigen CD86 isoform 1 precursor CD86 downregulates PubMed
CD86 downregulates PubMed
M-phase inducer phosphatase 1 isoform a CDC25A relocalizes PubMed
CDC25A relocalizes PubMed
M-phase inducer phosphatase 2 isoform 1 CDC25B relocalizes PubMed
CDC25B relocalizes PubMed
M-phase inducer phosphatase 3 isoform a CDC25C relocalizes PubMed
CDC25C relocalizes PubMed
CDC25C interacts with PubMed
CDC25C binds PubMed
CDC25C binds PubMed
CDC25C complexes with PubMed
CDC25C induces release of PubMed
CDC25C inactivates PubMed
CDC25C inactivates PubMed
CDC25C inactivates PubMed
cadherin-1 isoform 1 preproprotein CDH1 upregulates PubMed
cyclin-dependent kinase 1 isoform 1 CDK1 inactivates PubMed
CDK1 interacts with PubMed
CDK1 interacts with PubMed
CDK1 inactivates PubMed
CDK1 inhibits PubMed
CDK1 activates PubMed
CDK1 inactivates PubMed
CDK1 inactivates PubMed
CDK1 inactivates PubMed
cyclin-dependent kinase 7 isoform 1 CDK7 inhibited by PubMed
CDK7 enhanced by PubMed
cyclin-dependent kinase 9 CDK9 interacts with PubMed
cyclin-dependent kinase inhibitor 1 isoform 1 CDKN1A activates PubMed
CDKN1A upregulates PubMed
CDKN1A interacts with PubMed
CDKN1A upregulates PubMed
CDKN1A activates PubMed
DNA replication factor Cdt1 CDT1 cooperates with PubMed
CCAAT/enhancer-binding protein beta isoform a CEBPB cooperates with PubMed
CEBPB cooperates with PubMed
CEBPB activates PubMed
CEBPB activates PubMed
CCAAT/enhancer-binding protein delta CEBPD involves PubMed
CEBPD involves PubMed
histone H3-like centromeric protein A isoform a CENPA co-localizes with PubMed
centromere protein F CENPF upregulates PubMed
centromere protein H CENPH co-localizes with PubMed
centrosomal protein of 170 kDa isoform alpha CEP170 interacts with PubMed
centrin-2 CETN2 induces accumulation of PubMed
serine/threonine-protein kinase Chk1 isoform 1 CHEK1 activates PubMed
CHEK1 induces phosphorylation of PubMed
CHEK1 induces phosphorylation of PubMed
serine/threonine-protein kinase Chk2 isoform a CHEK2 induces phosphorylation of PubMed
CHEK2 induces phosphorylation of PubMed
chitinase-3-like protein 1 precursor CHI3L1 upregulates PubMed
inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 CHUK requires PubMed
cold-inducible RNA-binding protein isoform 1 CIRBP upregulates PubMed
chloride intracellular channel protein 1 CLIC1 downregulates PubMed
clathrin light chain A isoform a CLTA mediated by PubMed
clathrin light chain B isoform a CLTB mediated by PubMed
clathrin heavy chain 1 isoform 1 CLTC upregulates PubMed
CLTC mediated by PubMed
catechol O-methyltransferase isoform MB-COMT COMT interacts with PubMed
COP9 signalosome complex subunit 2 isoform 1 COPS2 interacts with PubMed
COP9 signalosome complex subunit 3 isoform 1 COPS3 interacts with PubMed
COP9 signalosome complex subunit 4 isoform 1 COPS4 interacts with PubMed
COP9 signalosome complex subunit 5 COPS5 interacts with PubMed
COP9 signalosome complex subunit 6 COPS6 interacts with PubMed
COPS6 interacts with PubMed
COPS6 interacts with PubMed
COPS6 interacts with PubMed
COPS6 binds PubMed
COP9 signalosome complex subunit 8 isoform 1 COPS8 interacts with PubMed
cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform 1 precursor COX4I1 co-localizes with PubMed
carnitine O-palmitoyltransferase 1, liver isoform isoform 1 CPT1A enhances PubMed
carnitine O-palmitoyltransferase 1, muscle isoform isoform a CPT1B enhances PubMed
cyclic AMP-responsive element-binding protein 1 isoform A CREB1 downregulates PubMed
CREB-binding protein isoform a CREBBP binds PubMed
cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM precursor CTLA4 upregulates PubMed
lysosomal protective protein isoform a precursor CTSA upregulates PubMed
cathepsin B isoform 1 preproprotein CTSB upregulates PubMed
cathepsin D preproprotein CTSD upregulates PubMed
pro-cathepsin H isoform a preproprotein CTSH upregulates PubMed
cathepsin Z preproprotein CTSZ upregulates PubMed
cullin-4A isoform 2 CUL4A induces PubMed
CUL4A induces complex with PubMed
CUL4A cooperates with PubMed
CUL4A complexes with PubMed
CUL4A interacts with PubMed
CUL4A interacts with PubMed
CUL4A interacts with PubMed
CUL4A interacts with PubMed
CUL4A interacts with PubMed
CUL4A co-localizes with PubMed
CUL4A complexes with PubMed
CUL4A interacts with PubMed
CUL4A binds PubMed
cullin-4B isoform 1 CUL4B complexes with PubMed
CUL4B interacts with PubMed
C-X-C motif chemokine 10 precursor CXCL10 upregulates PubMed
C-X-C motif chemokine 11 isoform 2 precursor CXCL11 upregulates PubMed
C-X-C motif chemokine 13 precursor CXCL13 upregulates PubMed
interleukin-8 isoform 1 precursor CXCL8 upregulates PubMed
CXCL8 downregulates PubMed
CXCL8 involves PubMed
CXCL8 involves PubMed
CXCL8 enhances PubMed
CXCL8 upregulates PubMed
CXCL8 upregulates PubMed
CXCL8 upregulates PubMed
CXCL8 enhances PubMed
CXCL8 involves PubMed
CXCL8 involves PubMed
CXCL8 involves PubMed
CXCL8 involves PubMed
CXCL8 regulates PubMed
cytochrome c1, heme protein, mitochondrial precursor CYC1 downregulates PubMed
CYC1 induces release of PubMed
cytochrome c CYCS induces release of PubMed
CYCS induces release of PubMed
cytoglobin CYGB downregulates PubMed
DDB1- and CUL4-associated factor 1 isoform 1 DCAF1 requires PubMed
DCAF1 cooperates with PubMed
DCAF1 binds PubMed
DCAF1 binds PubMed
DCAF1 requires PubMed
DCAF1 binds PubMed
DCAF1 recruits PubMed
DCAF1 complexes with PubMed
DCAF1 interacts with PubMed
DCAF1 recruits PubMed
DCAF1 complexes with PubMed
DCAF1 degrades PubMed
DCAF1 complexes with PubMed
DCAF1 interacts with PubMed
DCAF1 interacts with PubMed
DCAF1 interacts with PubMed
DCAF1 cooperates with PubMed
DCAF1 co-localizes with PubMed
DCAF1 binds PubMed
DCAF1 interacts with PubMed
DCAF1 interacts with PubMed
DCAF1 cooperates with PubMed
DCAF1 interacts with PubMed
DCAF1 binds PubMed
DCAF1 binds PubMed
DCAF1 cooperates with PubMed
DCAF1 cooperates with PubMed
DCAF1 co-localizes with PubMed
DCAF1 binds PubMed
DCAF1 interacts with PubMed
DCAF1 binds PubMed
DCAF1 binds PubMed
DDB1- and CUL4-associated factor 11 isoform 1 DCAF11 interacts with PubMed
DDB1- and CUL4-associated factor 8 DCAF8 interacts with PubMed
dynactin subunit 1 isoform 3 DCTN1 relocalizes PubMed
DET1- and DDB1-associated protein 1 DDA1 interacts with PubMed
DNA damage-binding protein 1 DDB1 enhances PubMed
DDB1 binds PubMed
DDB1 cooperates with PubMed
DDB1 degrades PubMed
DDB1 recruits PubMed
DDB1 complexes with PubMed
DDB1 complexes with PubMed
DDB1 interacts with PubMed
DDB1 induces complex with PubMed
DDB1 interacts with PubMed
DDB1 interacts with PubMed
DDB1 interacts with PubMed
DDB1 interacts with PubMed
DDB1 co-localizes with PubMed
DDB1 interacts with PubMed
DDB1 binds PubMed
DDB1 cooperates with PubMed
DDB1 stabilized by PubMed
DDB1 cooperates with PubMed
DDB1 inhibits PubMed
DDB1 interacts with PubMed
DNA damage-binding protein 2 isoform WT DDB2 inhibits PubMed
probable ATP-dependent RNA helicase DDX20 DDX20 interacts with PubMed
probable ATP-dependent RNA helicase DDX5 isoform a DDX5 upregulates PubMed
probable ATP-dependent RNA helicase DDX58 DDX58 upregulates PubMed
DDX58 upregulates PubMed
probable ATP-dependent RNA helicase DDX60 DDX60 upregulates PubMed
diacylglycerol kinase kappa DGKK upregulates PubMed
diablo homolog, mitochondrial isoform 1 precursor DIABLO induces release of PubMed
endoribonuclease Dicer isoform 1 DICER1 downregulates PubMed
DICER1 complexes with PubMed
dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform 1 precursor DLST upregulates PubMed
dnaJ homolog subfamily B member 2 isoform b DNAJB2 downregulates PubMed
dnaJ homolog subfamily B member 6 isoform a DNAJB6 facilitated by PubMed
dynamin-1-like protein isoform 3 DNM1L downregulates PubMed
DNM1L relocalizes PubMed
probable C-mannosyltransferase DPY19L1 isoform 2 DPY19L1 interacts with PubMed
probable C-mannosyltransferase DPY19L3 DPY19L3 interacts with PubMed
dual oxidase 2 precursor DUOX2 downregulates PubMed
dual specificity protein phosphatase 1 DUSP1 downregulates PubMed
cytoplasmic dynein 1 heavy chain 1 DYNC1H1 relocalizes PubMed
DYNC1H1 interacts with PubMed
DYNC1H1 interacts with PubMed
cytoplasmic dynein 1 intermediate chain 2 isoform 1 DYNC1I2 interacts with PubMed
cytoplasmic dynein 1 light intermediate chain 1 isoform 1 DYNC1LI1 interacts with PubMed
dynein light chain Tctex-type 1 isoform 1 DYNLT1 interacts with PubMed
dysferlin isoform 8 DYSF upregulates PubMed
interleukin-27 subunit beta precursor EBI3 downregulates PubMed
enoyl-CoA delta isomerase 1, mitochondrial isoform 1 precursor ECI1 downregulates PubMed
early endosome antigen 1 EEA1 upregulates PubMed
elongation factor 2 EEF2 inhibited by PubMed
eukaryotic translation initiation factor 4E isoform 1 EIF4E downregulates PubMed
eukaryotic translation initiation factor 4E-binding protein 1 EIF4EBP1 downregulates PubMed
crossover junction endonuclease EME1 isoform 2 EME1 interacts with PubMed
EME1 induces phosphorylation of PubMed
EME1 complexes with PubMed
histone acetyltransferase p300 isoform 1 EP300 interacts with PubMed
EP300 recruits PubMed
EP300 activates PubMed
EP300 activates PubMed
EP300 enhanced by PubMed
EP300 binds PubMed
EP300 binds PubMed
DNA excision repair protein ERCC-1 isoform 2 ERCC1 complexes with PubMed
DNA repair endonuclease XPF ERCC4 complexes with PubMed
electron transfer flavoprotein subunit alpha, mitochondrial isoform a ETFA downregulates PubMed
electron transfer flavoprotein subunit beta isoform 1 ETFB downregulates PubMed
persulfide dioxygenase ETHE1, mitochondrial isoform 1 ETHE1 downregulates PubMed
RNA-binding protein EWS isoform 1 EWSR1 upregulates PubMed
ezrin EZR downregulates PubMed
EZR upregulates PubMed
proteinase-activated receptor 1 isoform 2 F2R blocks PubMed
Fanconi anemia group D2 protein isoform a FANCD2 increases PubMed
tumor necrosis factor receptor superfamily member 6 isoform 1 precursor FAS cooperates with PubMed
high affinity immunoglobulin epsilon receptor subunit gamma precursor FCER1G upregulates PubMed
low affinity immunoglobulin gamma Fc region receptor II-c precursor FCGR2C upregulates PubMed
low affinity immunoglobulin gamma Fc region receptor III-A isoform a FCGR3A antagonizes PubMed
fumarate hydratase, mitochondrial FH upregulates PubMed
filamin-A isoform 2 FLNA upregulates PubMed
filamin-B isoform 1 FLNB upregulates PubMed
proto-oncogene c-Fos FOS regulated by PubMed
FOS activates PubMed
forkhead box protein M1 isoform 2 FOXM1 downregulates PubMed
forkhead box protein O3 FOXO3 inhibits PubMed
FOXO3 inhibits PubMed
ferritin heavy chain FTH1 upregulates PubMed
ferritin light chain FTL downregulates PubMed
ras GTPase-activating protein-binding protein 2 isoform a G3BP2 upregulates PubMed
glucose-6-phosphate 1-dehydrogenase isoform a G6PD upregulates PubMed
growth arrest and DNA damage-inducible protein GADD45 alpha isoform 1 GADD45A upregulates PubMed
glyceraldehyde-3-phosphate dehydrogenase isoform 1 GAPDH downregulates PubMed
GAPDH downregulates PubMed
guanylate-binding protein 5 GBP5 antagonizes PubMed
gem-associated protein 2 isoform alpha GEMIN2 interacts with PubMed
gem-associated protein 4 GEMIN4 interacts with PubMed
gem-associated protein 6 GEMIN6 interacts with PubMed
gem-associated protein 7 GEMIN7 interacts with PubMed
glial fibrillary acidic protein isoform 1 GFAP interacts with PubMed
ADP-ribosylation factor-binding protein GGA1 isoform 1 GGA1 co-localizes with PubMed
ADP-ribosylation factor-binding protein GGA2 GGA2 co-localizes with PubMed
ADP-ribosylation factor-binding protein GGA3 isoform short GGA3 co-localizes with PubMed
glutamate dehydrogenase 2, mitochondrial precursor GLUD2 downregulates PubMed
guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform 1 GNB1 upregulates PubMed
N-acetylglucosamine-6-sulfatase precursor GNS upregulates PubMed
Golgi phosphoprotein 3 GOLPH3 interacts with PubMed
glucose-6-phosphate isomerase isoform 2 GPI downregulates PubMed
COP9 signalosome complex subunit 1 isoform 2 GPS1 interacts with PubMed
epididymal secretory glutathione peroxidase isoform 1 precursor GPX5 upregulates PubMed
glycogen synthase kinase-3 beta isoform 1 GSK3B downregulates PubMed
gelsolin isoform a precursor GSN upregulates PubMed
GSN inhibited by PubMed
glutathione S-transferase kappa 1 isoform a GSTK1 downregulates PubMed
glutathione S-transferase P GSTP1 upregulates PubMed
transcription initiation factor IIB GTF2B binds PubMed
general transcription factor IIH subunit 1 GTF2H1 inhibited by PubMed
GTF2H1 enhanced by PubMed
histone H2AX H2AX interacts with PubMed
H2AX induces phosphorylation of PubMed
H2AX induces phosphorylation of PubMed
H2AX activates PubMed
hydroxyacyl-coenzyme A dehydrogenase, mitochondrial isoform 2 precursor HADH enhances PubMed
trifunctional enzyme subunit alpha, mitochondrial precursor HADHA downregulates PubMed
histone acetyltransferase type B catalytic subunit HAT1 complexes with PubMed
HAT1 interacts with PubMed
histone deacetylase 1 HDAC1 depletes PubMed
HDAC1 binds PubMed
HDAC1 depletes PubMed
HDAC1 cooperates with PubMed
histone deacetylase 2 HDAC2 depletes PubMed
HDAC2 cooperates with PubMed
histone deacetylase 3 isoform 2 HDAC3 depletes PubMed
HDAC3 binds PubMed
HDAC3 depletes PubMed
histone deacetylase 8 isoform 2 HDAC8 depletes PubMed
hepatoma-derived growth factor isoform a HDGF downregulates PubMed
hepatoma-derived growth factor-related protein 2 isoform 2 HDGFL2 interacts with PubMed
E3 ISG15--protein ligase HERC5 HERC5 upregulates PubMed
hypoxia-inducible factor 1-alpha isoform 1 HIF1A regulates PubMed
HIF1A upregulates PubMed
hexokinase-1 isoform HKI HK1 induces accumulation of PubMed
HK1 upregulates PubMed
HK1 upregulates PubMed
hexokinase-2 isoform 1 HK2 upregulates PubMed
HLA class I histocompatibility antigen, A-1 alpha chain A*03:01:0:01 precursor HLA-A upregulates PubMed
major histocompatibility complex, class I, B precursor HLA-B interacts with PubMed
HLA class I histocompatibility antigen, Cw-1 alpha chain precursor HLA-C interacts with PubMed
helicase-like transcription factor isoform 2 HLTF downregulates PubMed
HLTF binds PubMed
HLTF recruits PubMed
HLTF downregulates PubMed
HLTF downregulates PubMed
heterogeneous nuclear ribonucleoproteins A2/B1 isoform A2 HNRNPA2B1 regulated by PubMed
heterogeneous nuclear ribonucleoprotein D0 isoform c HNRNPD downregulates PubMed
heterogeneous nuclear ribonucleoprotein F HNRNPF regulated by PubMed
heterogeneous nuclear ribonucleoprotein H isoform a HNRNPH1 regulated by PubMed
heterogeneous nuclear ribonucleoprotein U isoform b HNRNPU modulated by PubMed
hypoxanthine-guanine phosphoribosyltransferase HPRT1 downregulates PubMed
3-hydroxyacyl-CoA dehydrogenase type-2 isoform 1 HSD17B10 downregulates PubMed
peroxisomal multifunctional enzyme type 2 isoform 2 HSD17B4 upregulates PubMed
heat shock factor protein 1 HSF1 inhibits PubMed
HSF1 upregulates PubMed
heat shock protein HSP 90-beta isoform a HSP90AB1 upregulates PubMed
heat shock 70 kDa protein 1A HSPA1A interacts with PubMed
HSPA1A binds PubMed
HSPA1A inhibited by PubMed
HSPA1A inhibited by PubMed
HSPA1A competes with PubMed
heat shock 70 kDa protein 1B HSPA1B interacts with PubMed
HSPA1B competes with PubMed
heat shock-related 70 kDa protein 2 HSPA2 upregulates PubMed
HSPA2 interacts with PubMed
HSPA2 competes with PubMed
heat shock 70 kDa protein 4 HSPA4 interacts with PubMed
HSPA4 competes with PubMed
endoplasmic reticulum chaperone BiP precursor HSPA5 upregulates PubMed
HSPA5 interacts with PubMed
HSPA5 upregulates PubMed
HSPA5 competes with PubMed
heat shock 70 kDa protein 6 HSPA6 interacts with PubMed
HSPA6 competes with PubMed
heat shock cognate 71 kDa protein isoform 1 HSPA8 interacts with PubMed
HSPA8 competes with PubMed
stress-70 protein, mitochondrial precursor HSPA9 interacts with PubMed
HSPA9 competes with PubMed
heat shock protein beta-1 HSPB1 competes with PubMed
HSPB1 inhibited by PubMed
60 kDa heat shock protein, mitochondrial HSPD1 downregulates PubMed
hypoxia up-regulated protein 1 precursor HYOU1 upregulates PubMed
isocitrate dehydrogenase IDH2 downregulates PubMed
indoleamine 2,3-dioxygenase 1 IDO1 downregulates PubMed
gamma-interferon-inducible protein 16 isoform 1 IFI16 antagonizes PubMed
interferon alpha-inducible protein 27, mitochondrial isoform 2 IFI27 upregulates PubMed
IFI27 upregulates PubMed
interferon-induced 35 kDa protein isoform 1 IFI35 upregulates PubMed
interferon-induced protein 44-like IFI44L upregulates PubMed
IFI44L upregulates PubMed
interferon alpha-inducible protein 6 isoform c precursor IFI6 upregulates PubMed
interferon-induced helicase C domain-containing protein 1 IFIH1 upregulates PubMed
interferon-induced protein with tetratricopeptide repeats 1 isoform 1 IFIT1 antagonizes PubMed
IFIT1 upregulates PubMed
IFIT1 upregulates PubMed
interferon-induced protein with tetratricopeptide repeats 2 IFIT2 upregulates PubMed
IFIT2 upregulates PubMed
interferon-induced protein with tetratricopeptide repeats 3 isoform a IFIT3 upregulates PubMed
interferon-induced transmembrane protein 1 IFITM1 interacts with PubMed
IFITM1 upregulates PubMed
IFITM1 interacts with PubMed
interferon-induced transmembrane protein 2 IFITM2 upregulates PubMed
IFITM2 interacts with PubMed
interferon-induced transmembrane protein 3 IFITM3 upregulates PubMed
IFITM3 interacts with PubMed
interferon alpha-1/13 precursor IFNA1 abrogated by PubMed
IFNA1 inhibits PubMed
IFNA1 inhibits PubMed
IFNA1 upregulates PubMed
interferon alpha-10 precursor IFNA10 inhibits PubMed
IFNA13 inhibits PubMed
interferon alpha-14 precursor IFNA14 inhibits PubMed
interferon alpha-16 precursor IFNA16 inhibits PubMed
interferon alpha-17 precursor IFNA17 inhibits PubMed
interferon alpha-2 precursor IFNA2 antagonizes PubMed
IFNA2 inhibits PubMed
interferon alpha-21 precursor IFNA21 inhibits PubMed
interferon alpha-4 precursor IFNA4 inhibits PubMed
interferon alpha-5 precursor IFNA5 inhibits PubMed
interferon alpha-6 precursor IFNA6 inhibits PubMed
interferon alpha-7 precursor IFNA7 inhibits PubMed
interferon alpha-8 precursor IFNA8 inhibits PubMed
interferon beta precursor IFNB1 inhibits PubMed
interferon gamma precursor IFNG inhibits PubMed
IFNG downregulates PubMed
IFNG downregulates PubMed
IFNG upregulates PubMed
inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1 IKBKB requires PubMed
IKBKB induces phosphorylation of PubMed
interleukin-10 precursor IL10 upregulates PubMed
IL10 modulates PubMed
interleukin-12 subunit alpha isoform 1 precursor IL12A modulates PubMed
IL12A downregulates PubMed
IL12A downregulates PubMed
IL12A downregulates PubMed
interleukin-12 subunit beta precursor IL12B downregulates PubMed
interleukin-1 alpha precursor IL1A upregulates PubMed
interleukin-1 beta proprotein IL1B activates PubMed
interleukin-2 precursor IL2 downregulates PubMed
IL2 downregulates PubMed
interleukin-4 isoform 1 precursor IL4 downregulates PubMed
interleukin-6 isoform 1 precursor IL6 upregulates PubMed
IL6 upregulates PubMed
IL6 involves PubMed
IL6 involves PubMed
IL6 enhances PubMed
IL6 upregulates PubMed
IL6 upregulates PubMed
IL6 upregulates PubMed
IL6 enhances PubMed
IL6 involves PubMed
IL6 involves PubMed
IL6 involves PubMed
IL6 involves PubMed
IL6 downregulates PubMed
IL6 upregulates PubMed
IL6 upregulates PubMed
IL6 upregulates PubMed
interleukin enhancer-binding factor 3 isoform b ILF3 downregulates PubMed
inner centromere protein isoform 2 INCENP upregulates PubMed
INCENP relocalizes PubMed
INCENP downregulates PubMed
insulin preproprotein INS inhibits PubMed
INS inhibits PubMed
INS inhibits PubMed
importin-5 IPO5 interacts with PubMed
IPO5 regulates PubMed
importin-7 IPO7 imported by PubMed
interferon regulatory factor 3 isoform 1 IRF3 induces cleavage of PubMed
IRF3 inhibits PubMed
IRF3 degrades PubMed
interferon regulatory factor 7 isoform a IRF7 upregulates PubMed
ubiquitin-like protein ISG15 ISG15 upregulates PubMed
ISG15 upregulates PubMed
interferon-stimulated gene 20 kDa protein isoform a ISG20 upregulates PubMed
isochorismatase domain-containing protein 2 isoform 2 ISOC2 downregulates PubMed
integrin alpha-5 precursor ITGA5 upregulates PubMed
integrin alpha-6 isoform b preproprotein ITGA6 upregulates PubMed
integrin alpha-M isoform 2 precursor ITGAM upregulates PubMed
integrin alpha-X isoform 2 precursor ITGAX upregulates PubMed
integrin beta-1 isoform 1A precursor ITGB1 upregulates PubMed
integrin beta-2 isoform 1 precursor ITGB2 upregulates PubMed
transcription factor AP-1 JUN involves PubMed
JUN involves PubMed
JUN regulated by PubMed
JUN activates PubMed
lysine--tRNA ligase isoform 2 KARS1 relocalizes PubMed
KARS1 inhibits PubMed
far upstream element-binding protein 2 isoform 1 KHSRP upregulates PubMed
kinesin-like protein KIF22 isoform 1 KIF22 upregulates PubMed
kinesin-like protein KIF2C isoform 1 KIF2C upregulates PubMed
kinesin-like protein KIFC1 KIFC1 upregulates PubMed
importin subunit alpha-5 KPNA1 binds PubMed
KPNA1 interacts with PubMed
KPNA1 binds PubMed
KPNA1 interacts with PubMed
KPNA1 imported by PubMed
KPNA1 interacts with PubMed
importin subunit alpha-1 KPNA2 binds PubMed
KPNA2 binds PubMed
KPNA2 binds PubMed
KPNA2 imported by PubMed
KPNA2 interacts with PubMed
KPNA2 interacts with PubMed
importin subunit alpha-3 KPNA4 binds PubMed
importin subunit beta-1 isoform 1 KPNB1 interacts with PubMed
KPNB1 regulates PubMed
lysosome-associated membrane glycoprotein 1 precursor LAMP1 inhibits PubMed
LAMP1 abrogates PubMed
LAMP1 downregulates PubMed
lysosome-associated membrane glycoprotein 2 isoform C precursor LAMP2 reduces PubMed
linker for activation of T-cells family member 2 precursor LAT2 upregulates PubMed
mitochondrial proton/calcium exchanger protein precursor LETM1 downregulates PubMed
galectin-3 isoform 2 LGALS3 upregulates PubMed
lamin isoform A LMNA downregulates PubMed
LMNA co-localizes with PubMed
lamin-B1 isoform 1 LMNB1 downregulates PubMed
LMNB1 co-localizes with PubMed
lamin-B2 LMNB2 downregulates PubMed
LMNB2 co-localizes with PubMed
LIM domain only protein 7 isoform 3 LMO7 upregulates PubMed
dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 cooperates with PubMed
dual specificity mitogen-activated protein kinase kinase 2 MAP2K2 cooperates with PubMed
MAP2K2 decreases phosphorylation of PubMed
MAP2K2 downregulates PubMed
dual specificity mitogen-activated protein kinase kinase 7 isoform 3 MAP2K7 induces phosphorylation of PubMed
MAP2K7 activates PubMed
mitogen-activated protein kinase kinase kinase 7 isoform A MAP3K7 enhances PubMed
MAP3K7 activates PubMed
MAP3K7 interacts with PubMed
MAP3K7 induces phosphorylation of PubMed
MAP3K7 induces phosphorylation of PubMed
mitogen-activated protein kinase 1 MAPK1 activates PubMed
mitogen-activated protein kinase 11 MAPK11 involves PubMed
MAPK11 involves PubMed
mitogen-activated protein kinase 13 MAPK13 involves PubMed
MAPK13 regulated by PubMed
mitogen-activated protein kinase 14 isoform 1 MAPK14 cooperates with PubMed
MAPK14 cooperates with PubMed
mitogen-activated protein kinase 3 isoform 1 MAPK3 activates PubMed
mitogen-activated protein kinase 8 isoform alpha2 MAPK8 involves PubMed
MAPK8 involves PubMed
MAPK8 involves PubMed
MAPK8 activates PubMed
MAP kinase-activated protein kinase 2 isoform 1 MAPKAPK2 requires PubMed
microtubule-associated protein RP/EB family member 1 MAPRE1 relocalizes PubMed
MAPRE1 interacts with PubMed
macrophage receptor MARCO MARCO stimulates PubMed
matrin-3 isoform a MATR3 upregulates PubMed
MATR3 interacts with PubMed
induced myeloid leukemia cell differentiation protein Mcl-1 isoform 1 MCL1 interacts with PubMed
protein MCM10 homolog isoform 2 MCM10 depletes PubMed
MCM10 enhances PubMed
MCM10 degrades PubMed
DNA replication licensing factor MCM3 isoform 1 MCM3 downregulates PubMed
DNA replication licensing factor MCM5 MCM5 downregulates PubMed
DNA replication licensing factor MCM6 MCM6 downregulates PubMed
malate dehydrogenase, mitochondrial isoform 1 precursor MDH2 downregulates PubMed
mitofusin-2 MFN2 downregulates PubMed
microsomal glutathione S-transferase 3 MGST3 downregulates PubMed
macrophage migration inhibitory factor MIF upregulates PubMed
protein MIS12 homolog MIS12 relocalizes PubMed
mitotic interactor and substrate of PLK1 MISP upregulates PubMed
MAP kinase-interacting serine/threonine-protein kinase 2 isoform 1 MKNK2 downregulates PubMed
interstitial collagenase isoform 1 preproprotein MMP1 downregulates PubMed
CDK-activating kinase assembly factor MAT1 isoform 1 MNAT1 inhibited by PubMed
MNAT1 enhanced by PubMed
mannosyl-oligosaccharide glucosidase isoform 1 MOGS interacts with PubMed
moesin MSN downregulates PubMed
metallothionein-3 MT3 downregulates PubMed
metastasis-associated protein MTA2 isoform 1 MTA2 interacts with PubMed
mitochondrial carrier homolog 2 isoform 1 MTCH2 interacts with PubMed
protein LYRIC isoform 1 MTDH upregulates PubMed
crossover junction endonuclease MUS81 isoform 2 MUS81 downregulates PubMed
MUS81 affects PubMed
MUS81 interacts with PubMed
MUS81 degrades PubMed
MUS81 induces ubiquitination of PubMed
MUS81 interacts with PubMed
MUS81 complexes with PubMed
interferon-induced GTP-binding protein Mx1 isoform a MX1 upregulates PubMed
MX1 upregulates PubMed
MX1 downregulates PubMed
interferon-induced GTP-binding protein Mx2 MX2 upregulates PubMed
MX2 upregulates PubMed
myeloid differentiation primary response protein MyD88 isoform 2 MYD88 cooperates with PubMed
myosin-11 isoform SM1A MYH11 upregulates PubMed
myosin-9 MYH9 upregulates PubMed
myosin light polypeptide 6 isoform 1 MYL6 upregulates PubMed
unconventional myosin-Ig MYO1G downregulates PubMed
nuclear receptor coactivator 1 isoform 1 NCOA1 enhances PubMed
NADH dehydrogenase NDUFS8 interacts with PubMed
NDUFV3 upregulates PubMed
E3 ubiquitin-protein ligase NEDD4-like isoform 3 NEDD4L interacts with PubMed
neurofilament medium polypeptide isoform 1 NEFM downregulates PubMed
nuclear factor of activated T-cells, cytoplasmic 1 isoform B NFATC1 induces PubMed
NFATC1 stimulates PubMed
NFATC1 upregulates PubMed
nuclear factor of activated T-cells, cytoplasmic 2 isoform B NFATC2 upregulates PubMed
nuclear factor of activated T-cells, cytoplasmic 3 isoform 2 NFATC3 upregulates PubMed
nuclear factor of activated T-cells, cytoplasmic 4 isoform 2 NFATC4 upregulates PubMed
nuclear factor NF-kappa-B p105 subunit isoform 1 NFKB1 activates PubMed
NFKB1 activates PubMed
NFKB1 activates PubMed
NFKB1 enhances PubMed
NFKB1 involves PubMed
NFKB1 involves PubMed
NFKB1 involves PubMed
NFKB1 involves PubMed
NFKB1 inhibits PubMed
NFKB1 regulates PubMed
NFKB1 activates PubMed
NFKB1 regulated by PubMed
NFKB1 activates PubMed
NFKB1 inhibits PubMed
NFKB1 activates PubMed
NFKB1 inhibits PubMed
NFKB1 activates PubMed
NFKB1 activates PubMed
NFKB1 activates PubMed
NFKB1 activates PubMed
NFKB1 interacts with PubMed
NFKB1 downregulates PubMed
NFKB1 inhibits PubMed
nuclear factor NF-kappa-B p100 subunit isoform b NFKB2 induces phosphorylation of PubMed
NF-kappa-B inhibitor alpha NFKBIA induces phosphorylation of PubMed
NFKBIA upregulates PubMed
NFKBIA upregulates PubMed
NF-kappa-B inhibitor beta isoform 1 NFKBIB induces phosphorylation of PubMed
NFKBIB upregulates PubMed
beta-nerve growth factor precursor NGF inhibited by PubMed
nucleotide-binding oligomerization domain-containing protein 2 isoform 2 NOD2 upregulates PubMed
non-POU domain-containing octamer-binding protein isoform 1 NONO upregulates PubMed
nitric oxide synthase, inducible NOS2 upregulates PubMed
nucleophosmin isoform 1 NPM1 downregulates PubMed
glucocorticoid receptor isoform alpha NR3C1 interacts with PubMed
NR3C1 interacts with PubMed
NR3C1 activates PubMed
NR3C1 activates PubMed
NR3C1 activates PubMed
NR3C1 complexes with PubMed
NR3C1 activates PubMed
NR3C1 activates PubMed
NR3C1 activates PubMed
NR3C1 activates PubMed
NR3C1 activates PubMed
NR3C1 activates PubMed
NR3C1 activates PubMed
nuclear receptor subfamily 4 group A member 1 isoform 1 NR4A1 downregulates PubMed
high affinity nerve growth factor receptor isoform 2 precursor NTRK1 downregulates PubMed
nuclear pore complex protein Nup153 isoform 2 NUP153 interacts with PubMed
nucleoporin NUP42 isoform 2 NUP42 affects PubMed
NUP42 binds PubMed
NUP42 interacts with PubMed
nucleoporin p54 isoform 1 NUP54 binds PubMed
nuclear pore complex protein Nup85 isoform 1 NUP85 induces accumulation of PubMed
2'-5'-oligoadenylate synthase 1 isoform 3 OAS1 antagonizes PubMed
2'-5'-oligoadenylate synthase 2 isoform 3 OAS2 upregulates PubMed
2'-5'-oligoadenylate synthase 3 OAS3 upregulates PubMed
2'-5'-oligoadenylate synthase-like protein isoform c OASL upregulates PubMed
2-oxoglutarate dehydrogenase, mitochondrial isoform 1 precursor OGDH upregulates PubMed
dynamin-like 120 kDa protein, mitochondrial isoform 1 preproprotein OPA1 upregulates PubMed
protein disulfide-isomerase precursor P4HB upregulates PubMed
proliferation-associated protein 2G4 PA2G4 downregulates PubMed
poly(A) polymerase alpha isoform 1 PAPOLA decreases phosphorylation of PubMed
poly PARP1 recruits PubMed
PARP1 induces cleavage of PubMed
pericentrin isoform 1 PCNT induces accumulation of PubMed
proprotein convertase subtilisin/kexin type 5 isoform PC6A preproprotein PCSK5 cleaved by PubMed
proprotein convertase subtilisin/kexin type 6 isoform PACE4-AI preproprotein PCSK6 involves PubMed
PCSK6 cleaves PubMed
PCSK6 cleaved by PubMed
pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial isoform 1 precursor PDHA1 induces phosphorylation of PubMed
protein disulfide-isomerase A3 precursor PDIA3 downregulates PubMed
pyruvate dehydrogenase kinase, isozyme 4 PDK4 enhances PubMed
PDK4 enhances PubMed
platelet endothelial cell adhesion molecule precursor PECAM1 upregulates PubMed
profilin-1 PFN1 downregulates PubMed
membrane-associated progesterone receptor component 2 PGRMC2 upregulates PubMed
prohibitin isoform 1 PHB downregulates PubMed
PHB modulates PubMed
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform PIK3CA involves PubMed
PIK3CA involves PubMed
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform 2 PIK3CB involves PubMed
PIK3CB involves PubMed
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform 1 PIK3CD involves PubMed
PIK3CD involves PubMed
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG involves PubMed
PIK3CG involves PubMed
pyruvate kinase PKM isoform a PKM upregulates PubMed
plectin isoform 1c PLEC upregulates PubMed
serine/threonine-protein kinase PLK1 PLK1 affects PubMed
PLK1 interacts with PubMed
DNA polymerase alpha catalytic subunit isoform 1 POLA1 downregulates PubMed
DNA-directed RNA polymerase II subunit RPB1 POLR2A activates PubMed
DNA-directed RNA polymerase II subunit RPB2 isoform 1 POLR2B activates PubMed
DNA-directed RNA polymerase II subunit RPB3 POLR2C activates PubMed
DNA-directed RNA polymerase II subunit RPB4 POLR2D activates PubMed
DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform a POLR2E activates PubMed
DNA-directed RNA polymerases I, II, and III subunit RPABC2 isoform 1 POLR2F activates PubMed
DNA-directed RNA polymerase II subunit RPB7 POLR2G activates PubMed
DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 2 POLR2H activates PubMed
DNA-directed RNA polymerase II subunit RPB9 POLR2I activates PubMed
DNA-directed RNA polymerase II subunit RPB11-a isoform 1 POLR2J activates PubMed
DNA-directed RNA polymerases I, II, and III subunit RPABC4 POLR2K activates PubMed
DNA-directed RNA polymerases I, II, and III subunit RPABC5 POLR2L activates PubMed
protein GRINL1A isoform 1 POLR2M activates PubMed
ribonuclease P protein subunit p29 POP4 downregulates PubMed
peroxisome proliferator-activated receptor delta isoform 1 PPARD cooperates with PubMed
PPARD enhances PubMed
PPARD enhances PubMed
PPARD interacts with PubMed
peptidyl-prolyl cis-trans isomerase A isoform 1 PPIA interacts with PubMed
PPIA enhanced by PubMed
PPIA isomerized by PubMed
serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 1 PPP2CA binds PubMed
PPP2CA upregulates PubMed
PPP2CA activates PubMed
serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB binds PubMed
PPP2CB upregulates PubMed
PPP2CB activates PubMed
serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform 1 PPP2R1A interacts with PubMed
PPP2R1A interacts with PubMed
PPP2R1A interacts with PubMed
PPP2R1A binds PubMed
PPP2R1A upregulates PubMed
PPP2R1A activates PubMed
serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform a PPP2R1B binds PubMed
PPP2R1B upregulates PubMed
PPP2R1B activates PubMed
serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 1 PPP2R2A binds PubMed
PPP2R2A activates PubMed
PPP2R2A upregulates PubMed
PPP2R2A activates PubMed
serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform a PPP2R2B binds PubMed
PPP2R2B activates PubMed
PPP2R2B upregulates PubMed
PPP2R2B activates PubMed
protein phosphatase 2, regulatory subunit B, gamma isoform b PPP2R2C activates PubMed
PPP2R2C upregulates PubMed
PPP2R2C activates PubMed
serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 1 PPP2R3A binds PubMed
PPP2R3A activates PubMed
PPP2R3A upregulates PubMed
PPP2R3A activates PubMed
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform 1 PPP2R5A binds PubMed
PPP2R5A upregulates PubMed
PPP2R5A activates PubMed
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform PPP2R5B binds PubMed
PPP2R5B upregulates PubMed
PPP2R5B activates PubMed
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform a PPP2R5C binds PubMed
PPP2R5C upregulates PubMed
PPP2R5C activates PubMed
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform 1 PPP2R5D binds PubMed
PPP2R5D upregulates PubMed
PPP2R5D activates PubMed
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform a PPP2R5E binds PubMed
PPP2R5E upregulates PubMed
PPP2R5E activates PubMed
5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1 PRKAA1 phosphorylated by PubMed
5'-AMP-activated protein kinase catalytic subunit alpha-2 PRKAA2 phosphorylated by PubMed
5'-AMP-activated protein kinase subunit beta-1 PRKAB1 phosphorylated by PubMed
5'-AMP-activated protein kinase subunit beta-2 PRKAB2 phosphorylated by PubMed
cAMP-dependent protein kinase catalytic subunit alpha isoform Calpha1 PRKACA interacts with PubMed
PRKACA phosphorylated by PubMed
cAMP-dependent protein kinase catalytic subunit beta isoform 2 PRKACB phosphorylated by PubMed
cAMP-dependent protein kinase catalytic subunit gamma PRKACG phosphorylated by PubMed
5'-AMP-activated protein kinase subunit gamma-1 isoform 1 PRKAG1 phosphorylated by PubMed
5'-AMP-activated protein kinase subunit gamma-2 isoform a PRKAG2 phosphorylated by PubMed
cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a PRKAR1A phosphorylated by PubMed
cAMP-dependent protein kinase type I-beta regulatory subunit PRKAR1B phosphorylated by PubMed
cAMP-dependent protein kinase type II-alpha regulatory subunit isoform a PRKAR2A phosphorylated by PubMed
cAMP-dependent protein kinase type II-beta regulatory subunit PRKAR2B phosphorylated by PubMed
protein kinase C iota type PRKCI regulated by PubMed
protein kinase C zeta type isoform 1 PRKCZ regulated by PubMed
26S proteasome non-ATPase regulatory subunit 2 isoform 1 PSMD2 interacts with PubMed
26S proteasome non-ATPase regulatory subunit 4 isoform 2 PSMD4 interacts with PubMed
prostaglandin E synthase 3 isoform a PTGES3 interacts with PubMed
prostaglandin G/H synthase 2 precursor PTGS2 downregulates PubMed
serine/threonine-protein phosphatase 2A activator isoform b PTPA binds PubMed
PTPA activates PubMed
PTPA upregulates PubMed
PTPA activates PubMed
poliovirus receptor isoform alpha precursor PVR upregulates PubMed
PVR upregulates PubMed
peroxidasin-like protein precursor PXDNL upregulates PubMed
ras-related protein Rab-7a RAB7A upregulates PubMed
cell cycle checkpoint protein RAD17 isoform 1 RAD17 requires PubMed
double-strand-break repair protein rad21 homolog RAD21 downregulates PubMed
UV excision repair protein RAD23 homolog A isoform 1 RAD23A binds PubMed
RAD23A binds PubMed
RAD23A complexes with PubMed
RAD23A binds PubMed
RAD23A cooperates with PubMed
RAD23A inhibits PubMed
RAD23A binds PubMed
RAD23A inhibited by PubMed
DNA repair protein RAD51 homolog 1 isoform 1 RAD51 inhibits PubMed
RAD51 stimulates PubMed
ras-related protein Ral-A precursor RALA upregulates PubMed
histone-binding protein RBBP7 isoform 2 RBBP7 complexes with PubMed
RBBP7 interacts with PubMed
retinol dehydrogenase 11 isoform 1 precursor RDH11 upregulates PubMed
radixin isoform 2 RDX downregulates PubMed
proto-oncogene c-Rel isoform 1 REL upregulates PubMed
transcription factor p65 isoform 1 RELA activates PubMed
RELA regulated by PubMed
RELA induces phosphorylation of PubMed
RELA inhibits PubMed
RELA downregulates PubMed
RELA cooperates with PubMed
RELA inhibits PubMed
RELA activates PubMed
transcription factor RelB RELB interacts with PubMed
RELB cooperates with PubMed
RELB interacts with PubMed
transforming protein RhoA isoform 1 precursor RHOA upregulates PubMed
rho-related GTP-binding protein RhoB precursor RHOB upregulates PubMed
rho-related GTP-binding protein RhoG precursor RHOG upregulates PubMed
receptor-interacting serine/threonine-protein kinase 1 isoform 1 RIPK1 upregulates PubMed
GTP-binding protein Rit1 isoform 2 RIT1 induces complex with PubMed
proto-oncogene tyrosine-protein kinase ROS precursor ROS1 upregulates PubMed
replication protein A 70 kDa DNA-binding subunit isoform 1 RPA1 interacts with PubMed
replication protein A 32 kDa subunit isoform 1 RPA2 complexes with PubMed
RPA2 co-localizes with PubMed
RPA2 induces phosphorylation of PubMed
60S ribosomal protein L11 isoform 1 RPL11 downregulates PubMed
60S ribosomal protein L13 isoform 1 RPL13 downregulates PubMed
60S ribosomal protein L23a RPL23A downregulates PubMed
60S ribosomal protein L29 RPL29 downregulates PubMed
60S acidic ribosomal protein P0 RPLP0 downregulates PubMed
ribosome-binding protein 1 isoform 2 RRBP1 upregulates PubMed
radical S-adenosyl methionine domain-containing protein 2 RSAD2 upregulates PubMed
reticulon-4 isoform C RTN4 downregulates PubMed
protein S100-B S100B upregulates PubMed
secretory carrier-associated membrane protein 3 isoform 1 SCAMP3 upregulates PubMed
scavenger receptor class A member 3 isoform 1 SCARA3 downregulates PubMed
lysosome membrane protein 2 isoform 1 precursor SCARB2 downregulates PubMed
succinate dehydrogenase SDHA downregulates PubMed
stress-associated endoplasmic reticulum protein 1 SERP1 downregulates PubMed
plasminogen activator inhibitor 2 SERPINB2 downregulates PubMed
plasminogen activator inhibitor 1 precursor SERPINE1 downregulates PubMed
splicing factor 3B subunit 2 SF3B2 inhibits PubMed
SF3B2 binds PubMed
SF3B2 interacts with PubMed
splicing factor 3B subunit 4 SF3B4 inhibits PubMed
SF3B4 inhibits PubMed
shugoshin 1 isoform 1KL SGO1 relocalizes PubMed
SGO1 inhibits PubMed
calcium-binding mitochondrial carrier protein Aralar1 SLC25A12 downregulates PubMed
ADP/ATP translocase 1 SLC25A4 binds PubMed
SLC25A4 binds PubMed
SLC25A4 binds PubMed
ADP/ATP translocase 2 SLC25A5 downregulates PubMed
sodium/hydrogen exchanger 1 SLC9A1 downregulates PubMed
SLC9A1 downregulates PubMed
structure-specific endonuclease subunit SLX4 SLX4 interacts with PubMed
SLX4 regulates PubMed
SLX4 activates PubMed
SLX4 activates PubMed
SLX4 interacts with PubMed
SLX4 complexes with PubMed
protein SLX4IP SLX4IP interacts with PubMed
mothers against decapentaplegic homolog 3 isoform 1 SMAD3 activates PubMed
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 SMARCA5 binds PubMed
structural maintenance of chromosomes protein 1A isoform 1 SMC1A downregulates PubMed
structural maintenance of chromosomes protein 1B isoform 1 SMC1B downregulates PubMed
structural maintenance of chromosomes protein 3 SMC3 downregulates PubMed
survival motor neuron protein isoform d SMN1 downregulates PubMed
single-strand selective monofunctional uracil DNA glycosylase isoform 1 SMUG1 downregulates PubMed
SMUG1 downregulates PubMed
SMUG1 complexes with PubMed
small nuclear ribonucleoprotein-associated protein N SNRPN interacts with PubMed
sorbin and SH3 domain-containing protein 2 isoform 2 SORBS2 upregulates PubMed
transcription factor Sp1 isoform a SP1 cooperates with PubMed
SP1 cooperates with PubMed
SP1 interacts with PubMed
SP1 interacts with PubMed
leukosialin precursor SPN antagonizes PubMed
spectrin alpha chain, non-erythrocytic 1 isoform 1 SPTAN1 upregulates PubMed
spectrin beta chain, non-erythrocytic 1 isoform 1 SPTBN1 co-localizes with PubMed
sulfide:quinone oxidoreductase, mitochondrial SQOR upregulates PubMed
lupus La protein SSB downregulates PubMed
signal transducer and activator of transcription 1-alpha/beta isoform alpha STAT1 induces phosphorylation of PubMed
STAT1 activates PubMed
stimulator of interferon genes protein isoform 1 STING1 antagonizes PubMed
stomatin-like protein 2, mitochondrial isoform a STOML2 downregulates PubMed
succinate--CoA ligase SUCLG1 downregulates PubMed
histone-lysine N-methyltransferase SUV39H1 isoform 2 SUV39H1 inhibited by PubMed
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 TAB3 interacts with PubMed
transgelin-2 isoform b TAGLN2 upregulates PubMed
serine/threonine-protein kinase TBK1 TBK1 interacts with PubMed
TATA-box-binding protein isoform 1 TBP binds PubMed
transcription factor 12 isoform d TCF12 downregulates PubMed
telomerase reverse transcriptase isoform 1 TERT downregulates PubMed
TERT downregulates PubMed
tesmin isoform a TESMIN downregulates PubMed
transferrin receptor protein 1 isoform 1 TFRC upregulates PubMed
transforming growth factor beta-1 proprotein preproprotein TGFB1 modulates PubMed
thrombospondin-1 precursor THBS1 stimulates PubMed
metalloproteinase inhibitor 1 precursor TIMP1 upregulates PubMed
thymidine kinase, cytosolic isoform 1 TK1 upregulates PubMed
transketolase isoform 1 TKT downregulates PubMed
toll-like receptor 4 isoform A precursor TLR4 cooperates with PubMed
TLR4 downregulates PubMed
transmembrane protein 11, mitochondrial TMEM11 interacts with PubMed
transmembrane protein 160 precursor TMEM160 interacts with PubMed
transmembrane protein 33 TMEM33 upregulates PubMed
tumor necrosis factor TNF enhances PubMed
TNF upregulates PubMed
TNF cooperates with PubMed
TNF inhibits PubMed
TNF upregulates PubMed
TNF inhibits PubMed
TNF modulates PubMed
tumor necrosis factor ligand superfamily member 10 isoform 1 TNFSF10 upregulates PubMed
tumor necrosis factor ligand superfamily member 11 isoform 1 TNFSF11 upregulates PubMed
tumor necrosis factor ligand superfamily member 15 isoform VEGI-192 TNFSF15 upregulates PubMed
tumor necrosis factor ligand superfamily member 9 TNFSF9 upregulates PubMed
transportin-1 isoform 1 TNPO1 interacts with PubMed
TNPO1 regulates PubMed
mitochondrial import receptor subunit TOM22 homolog TOMM22 downregulates PubMed
cellular tumor antigen p53 isoform a TP53 interacts with PubMed
TP53 upregulates PubMed
TP53 upregulates PubMed
TP53 upregulates PubMed
TP53 inhibits PubMed
TP53 interacts with PubMed
TP53 regulated by PubMed
TP53 activates PubMed
TP53 inhibits PubMed
TP53-binding protein 1 isoform 3 TP53BP1 interacts with PubMed
TP53BP1 co-localizes with PubMed
triosephosphate isomerase isoform 1 TPI1 downregulates PubMed
transformer-2 protein homolog alpha isoform 1 TRA2A activated by PubMed
transformer-2 protein homolog beta isoform 1 TRA2B activated by PubMed
TNF receptor-associated factor 1 isoform a TRAF1 mediated by PubMed
TNF receptor-associated factor 2 TRAF2 mediated by PubMed
TNF receptor-associated factor 6 TRAF6 interacts with PubMed
TRAF6 interacts with PubMed
E3 ubiquitin-protein ligase TRIM11 TRIM11 regulates PubMed
transient receptor potential cation channel subfamily V member 2 TRPV2 upregulates PubMed
tumor susceptibility gene 101 protein TSG101 competes with PubMed
TSG101 abrogates PubMed
testis-specific Y-encoded-like protein 1 TSPYL1 interacts with PubMed
tubulin beta-3 chain isoform 1 TUBB3 downregulates PubMed
tubulin gamma-1 chain TUBG1 induces accumulation of PubMed
tubulin gamma-2 chain isoform 2 TUBG2 induces accumulation of PubMed
tubby-related protein 3 isoform 1 TULP3 interacts with PubMed
thioredoxin-interacting protein isoform 2 TXNIP upregulates PubMed
ubiquitin-60S ribosomal protein L40 isoform 1 precursor UBA52 upregulates PubMed
ubiquitin-associated protein 2-like isoform a UBAP2L upregulates PubMed
polyubiquitin-B precursor UBB complexes with PubMed
UBB cooperates with PubMed
polyubiquitin-C UBC complexes with PubMed
UBC cooperates with PubMed
ubiquitin D UBD co-localizes with PubMed
UBD upregulates PubMed
E3 ubiquitin-protein ligase UBR1 UBR1 induces complex with PubMed
E3 ubiquitin-protein ligase UBR2 isoform 1 UBR2 complexes with PubMed
E3 ubiquitin-protein ligase UBR3 UBR3 complexes with PubMed
E3 ubiquitin-protein ligase UBR4 UBR4 complexes with PubMed
E3 ubiquitin-protein ligase UBR5 isoform 1 UBR5 interacts with PubMed
UBR5 complexes with PubMed
UL16-binding protein 1 isoform 1 precursor ULBP1 upregulates PubMed
ULBP1 upregulates PubMed
ULBP1 upregulates PubMed
ULBP1 upregulates PubMed
ULBP1 upregulates PubMed
UL16-binding protein 2 preproprotein ULBP2 upregulates PubMed
ULBP2 upregulates PubMed
ULBP2 upregulates PubMed
ULBP2 upregulates PubMed
ULBP2 upregulates PubMed
ULBP2 upregulates PubMed
ULBP2 upregulates PubMed
UL16-binding protein 3 ULBP3 upregulates PubMed
ULBP3 upregulates PubMed
ULBP3 upregulates PubMed
ULBP3 upregulates PubMed
uracil-DNA glycosylase isoform UNG2 UNG inhibits PubMed
UNG mimics DNA binding to PubMed
UNG depletes PubMed
UNG targets PubMed
UNG binds PubMed
UNG downregulates PubMed
UNG downregulates PubMed
UNG complexes with PubMed
UNG induces ubiquitination of PubMed
UNG degrades PubMed
UNG degrades PubMed
UNG degrades PubMed
UNG binds PubMed
UNG downregulates PubMed
UNG complexes with PubMed
UNG binds PubMed
UNG induces phosphorylation of PubMed
UNG activates PubMed
UNG interacts with PubMed
UNG binds PubMed
UNG incorporates PubMed
UNG induces ubiquitination of PubMed
UNG incorporates PubMed
UNG binds PubMed
general vesicular transport factor p115 isoform 2 USO1 upregulates PubMed
ubl carboxyl-terminal hydrolase 18 USP18 upregulates PubMed
synaptic vesicle membrane protein VAT-1 homolog VAT1 upregulates PubMed
voltage-dependent anion-selective channel protein 1 VDAC1 downregulates PubMed
VDAC1 interacts with PubMed
VDAC1 interacts with PubMed
voltage-dependent anion-selective channel protein 2 isoform 2 VDAC2 downregulates PubMed
VDAC2 interacts with PubMed
voltage-dependent anion-selective channel protein 3 isoform 1 VDAC3 interacts with PubMed
vimentin VIM downregulates PubMed
VIM modulates PubMed
wee1-like protein kinase isoform 1 WEE1 downregulates PubMed
WEE1 binds PubMed
WEE1 upregulates PubMed
WEE1 interacts with PubMed
WEE1 inhibited by PubMed
WEE1 induces release of PubMed
XIAP-associated factor 1 isoform 1 XAF1 upregulates PubMed
exportin-1 XPO1 exported by PubMed
XPO1 exported by PubMed
14-3-3 protein beta/alpha YWHAB inhibits PubMed
YWHAB enhanced by PubMed
14-3-3 protein epsilon YWHAE inhibits PubMed
YWHAE enhanced by PubMed
14-3-3 protein gamma YWHAG inhibits PubMed
YWHAG inhibits PubMed
YWHAG enhanced by PubMed
14-3-3 protein eta YWHAH inhibits PubMed
YWHAH complexes with PubMed
YWHAH binds PubMed
YWHAH enhanced by PubMed
14-3-3 protein theta YWHAQ interacts with PubMed
YWHAQ inhibits PubMed
YWHAQ binds PubMed
14-3-3 protein zeta/delta YWHAZ interacts with PubMed
YWHAZ inhibits PubMed
YWHAZ enhanced by PubMed
Z-DNA-binding protein 1 isoform b ZBP1 upregulates PubMed
zinc finger CCCH-type with G patch domain-containing protein isoform a ZGPAT degrades PubMed
ZGPAT complexes with PubMed
zinc finger protein 512 isoform a ZNF512 downregulates PubMed
zinc finger-containing ubiquitin peptidase 1 isoform 1 ZUP1 downregulates PubMed

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Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
Vpr
NP_057852.2
  • An artificial frameshift eliminating the orf-disrupting nucleotide at position 5320 is introduced to obtain the typical HIV-1 Vpr protein sequence. For this particular HIV-1 strain, HXB2, only a short (78 amino acid long) variant of the Vpr sequence can be obtained by translation of nucleotides 5105 through 5341 without the frameshift

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001802.1 Reference assembly

    Range
    5105..5396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_057852.2 Vpr [Human immunodeficiency virus 1]

    See identical proteins and their annotated locations for NP_057852.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A288CFT1
    Conserved Domains (1) summary
    pfam00522
    Location:182
    VPR; VPR/VPX protein
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