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CDCA2 cell division cycle associated 2 [ Homo sapiens (human) ]

Gene ID: 157313, updated on 5-Mar-2024

Summary

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Official Symbol
CDCA2provided by HGNC
Official Full Name
cell division cycle associated 2provided by HGNC
Primary source
HGNC:HGNC:14623
See related
Ensembl:ENSG00000184661 MIM:618785; AllianceGenome:HGNC:14623
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPP1R81; Repo-Man
Summary
This gene encodes a targeting subunit of the cell-cycle associated protein, protein phosphatase 1, with a role in targeting this protein to chromatin during anaphase. These two proteins comprise a phosphatase complex that is involved in nuclear envelope reformation and regulation of the DNA damage response. The encoded protein may also play a role in cancer progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Expression
Biased expression in testis (RPKM 7.7), lymph node (RPKM 1.9) and 9 other tissues See more
Orthologs
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Genomic context

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Location:
8p21.2
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (25458931..25507917)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (25734151..25783086)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (25316447..25365433)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27124 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19035 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19036 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27125 Neighboring gene gonadotropin releasing hormone 1 Neighboring gene potassium channel tetramerization domain containing 9 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:25336688-25337887 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:25338615-25339116 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:25339117-25339616 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:25348932-25349432 Neighboring gene Sharpr-MPRA regulatory region 1118 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:25457409-25458332 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:25472096-25472597 Neighboring gene uncharacterized LOC107986933 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:25517514-25518200 Neighboring gene uncharacterized LOC105379333 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:25532846-25533449 Neighboring gene NANOG hESC enhancer GRCh37_chr8:25537050-25537623 Neighboring gene uncharacterized LOC105379332

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. PPP1R81 correlates with the survival and cell proliferation in lower-grade glioma. Xiao F, et al. Biosci Rep, 2023 May 5. PMID 37083601, Free PMC Article
  2. CDCA2 Promotes HCC Cells Development via AKT-mTOR Pathway. Li K, et al. Anal Cell Pathol (Amst), 2022. PMID 36588796, Free PMC Article
  3. Repo-Man/protein phosphatase 1 SUMOylation mediates binding to lamin A and serine 22 dephosphorylation. Huguet F, et al. Open Biol, 2022 Apr. PMID 35414260, Free PMC Article
  4. The Higher Expression of CDCA2 Associated with Poor Prognosis in Glioma. Jin X, et al. Dis Markers, 2022. PMID 35386230, Free PMC Article
  5. CDCA2 promotes tumorigenesis and induces radioresistance in oesophageal squamous cell carcinoma cells. Xu B, et al. Mol Med Rep, 2021 Jul. PMID 34036376, Free PMC Article

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A pan-cancer analysis reveals the diagnostic and prognostic role of CDCA2 in low-grade glioma.
    Title: A pan-cancer analysis reveals the diagnostic and prognostic role of CDCA2 in low-grade glioma.
  2. CDCA2 promotes melanoma progression by inhibiting ubiquitin-mediated degradation of Aurora kinase A.
    Title: CDCA2 promotes melanoma progression by inhibiting ubiquitin-mediated degradation of Aurora kinase A.
  3. PPP1R81 correlates with the survival and cell proliferation in lower-grade glioma.
    Title: PPP1R81 correlates with the survival and cell proliferation in lower-grade glioma.
  4. Cell division cycle associated 2 (CDCA2) upregulation promotes the progression of hepatocellular carcinoma in a p53-dependant manner.
    Title: Cell division cycle associated 2 (CDCA2) upregulation promotes the progression of hepatocellular carcinoma in a p53-dependant manner.
  5. CDCA2 Promotes HCC Cells Development via AKT-mTOR Pathway.
    Title: CDCA2 Promotes HCC Cells Development via AKT-mTOR Pathway.
  6. Repo-Man/protein phosphatase 1 SUMOylation mediates binding to lamin A and serine 22 dephosphorylation.
    Title: Repo-Man/protein phosphatase 1 SUMOylation mediates binding to lamin A and serine 22 dephosphorylation.
  7. CDCA2 protects against oxidative stress by promoting BRCA1-NRF2 signaling in hepatocellular carcinoma.
    Title: CDCA2 protects against oxidative stress by promoting BRCA1-NRF2 signaling in hepatocellular carcinoma.
  8. RepoMan stimulates the chromosome-dependent pathway of microtubule assembly.
    Title: RepoMan stimulates the chromosome-dependent pathway of microtubule assembly.
  9. CDCA2 promotes tumorigenesis and induces radioresistance in oesophageal squamous cell carcinoma cells.
    Title: CDCA2 promotes tumorigenesis and induces radioresistance in oesophageal squamous cell carcinoma cells.
  10. CDCA2 promotes proliferation and migration of melanoma by upregulating CCAD1.
    Title: CDCA2 promotes proliferation and migration of melanoma by upregulating CCAD1.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ25804, MGC129906, MGC129907

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cell division cycle-associated protein 2
Names
protein phosphatase 1, regulatory subunit 81
recruits PP1 onto mitotic chromatin at anaphase protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317906.1 → NP_001304835.1  cell division cycle-associated protein 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) retains a 5' intron resulting in a distinct 5' UTR and the use of an alternate translation start site compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to variant 1.
    Source sequence(s)
    AA678348, AI022757, AK292505, AL833396, DB093475
    Consensus CDS
    CCDS83266.1
    UniProtKB/TrEMBL
    A8K8Z0, E9PEI0
    Related
    ENSP00000370040.3, ENST00000380665.3
    Conserved Domains (1) summary
    pfam15276
    Location:375 → 433
    PP1_bind; Protein phosphatase 1 binding

  2. NM_001317907.1 → NP_001304836.1  cell division cycle-associated protein 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AA678348, AI022757, AK292505, AK299278, AL833396, DB093475
    UniProtKB/TrEMBL
    B7Z5Q5
    Conserved Domains (1) summary
    pfam15276
    Location:390 → 448
    PP1_bind; Protein phosphatase 1 binding

  3. NM_152562.4 → NP_689775.2  cell division cycle-associated protein 2 isoform 1

    See identical proteins and their annotated locations for NP_689775.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA678348, AI022757, AK299278, AL833396, BC015691
    Consensus CDS
    CCDS6049.1
    UniProtKB/Swiss-Prot
    Q3SX74, Q4G0W0, Q5RKN0, Q69YH5, Q69YI4, Q6P464, Q8N7C1
    UniProtKB/TrEMBL
    A8K8Z0
    Related
    ENSP00000328228.3, ENST00000330560.8
    Conserved Domains (1) summary
    pfam15276
    Location:390 → 448
    PP1_bind; Protein phosphatase 1 binding

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    25458931..25507917
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    25734151..25783086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q69YH5.2 GenPept UniProtKB/Swiss-Prot:Q69YH5

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