CYP3A51P cytochrome P450 family 3 subfamily A member 51, pseudogene [Homo sapiens (human)] - Gene

Summary

Official Symbol: CYP3A51Pprovided by HGNC
Official Full Name: cytochrome P450 family 3 subfamily A member 51, pseudogeneprovided by HGNC
Primary source: HGNC:HGNC:42418
See related: Ensembl:ENSG00000282277 AllianceGenome:HGNC:42418
Gene type: pseudo
RefSeq status: INFERRED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CYP3AP1; CYP3A5P1; CYP3A5-de13c; CYP3A5-de1b2b
Summary: This locus represents a CYP3A pseudogene that is present within a cluster of CYP3A (cytochrome P450, family 3, subfamily A) genes on chromosome 7. This pseudogene is located between the CYP3A7 and CYP3A5 family members. It contains duplicates of exons 1, 2 and 13 that are found in the functional genes. Readthrough transcription exists between the CYP3A7 gene and this pseudogene, where the readthrough transcript includes CYP3A7 exons 1-13 and exons 2 and 13 of this pseudogene, as represented in GeneID:100861540. This pseudogene is not known to be independently transcribed. [provided by RefSeq, Feb 2012]
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Genomic context

Location:: 7q22.1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (99685024..99700120, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (100924543..100939637, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (99282647..99297743, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: CYP3AP1*3 allele is associated with lipid-lowering efficacy of simvastatin and atorvastatin in Chinese women.
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: CYP450 polymorphisms predict clinic outcomes to vinorelbine-based chemotherapy in patients with non-small-cell lung cancer.
Observational study of gene-disease association. (HuGE Navigator)
Title: Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients.
A novel mechanism, consisting of the splicing of the pseudogene CYP3AP1 (CYP3A5P1) to CYP3A7, causes the formation of the novel CYP3A7.1L.
Title: A novel polymorphic cytochrome P450 formed by splicing of CYP3A7 and the pseudogene CYP3AP1.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Readthrough CYP3A7-CYP3A51P

Readthrough gene: CYP3A7-CYP3A51P, Included gene: CYP3A7

Other Names

cytochrome P450, family 3, subfamily A, polypeptide 5 pseudogene 1
cytochrome P450, family 3, subfamily A, polypeptide 51, pseudogene
cytochrome P450, subfamily IIIA (niphedipine oxidase), pseudogene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.