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Iapp islet amyloid polypeptide [ Mus musculus (house mouse) ]

Gene ID: 15874, updated on 23-Jun-2021

Summary

Official Symbol
Iappprovided by MGI
Official Full Name
islet amyloid polypeptideprovided by MGI
Primary source
MGI:MGI:96382
See related
Ensembl:ENSMUSG00000041681
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
am; DAP
Expression
Biased expression in thymus adult (RPKM 1.6), genital fat pad adult (RPKM 1.5) and 10 other tissues See more
Orthologs
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Genomic context

See Iapp in Genome Data Viewer
Location:
6 G2; 6 73.81 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (142244151..142249546)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (142298425..142303820)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (142246945..142252340)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene solute carrier organic anion transporter family, member 1a6 Neighboring gene predicted gene, 18159 Neighboring gene predicted gene, 53313 Neighboring gene solute carrier organic anion transporter family, member 1a5 Neighboring gene 60S ribosomal protein L18 pseudogene Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 1 Neighboring gene RecQ protein-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in amylin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in amyloid fibril formation ISO
Inferred from Sequence Orthology
more info
 
involved_in eating behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of bone resorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in inclusion body ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
islet amyloid polypeptide
Names
amylin
diabetes-associated peptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010491.2NP_034621.1  islet amyloid polypeptide precursor

    See identical proteins and their annotated locations for NP_034621.1

    Status: VALIDATED

    Source sequence(s)
    BC027527, CJ042995
    Consensus CDS
    CCDS39694.1
    UniProtKB/Swiss-Prot
    P12968
    Related
    ENSMUSP00000043956.3, ENSMUST00000041993.3
    Conserved Domains (1) summary
    smart00113
    Location:3677
    CALCITONIN; calcitonin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    142244151..142249546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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