TCEAL6 transcription elongation factor A like 6 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TCEAL6provided by HGNC
Official Full Name: transcription elongation factor A like 6provided by HGNC
Primary source: HGNC:HGNC:24553
See related: AllianceGenome:HGNC:24553
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: WEX2; Tceal3
Summary: Predicted to enable WW domain binding activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: suggests misassembly
Expression: Biased expression in brain (RPKM 18.6), testis (RPKM 12.2) and 4 other tissues See more
Orthologs: all
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Genomic context

Location:: Xq22.1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (102138502..102142481, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (100583085..100587065, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (101393474..101397453, complement)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

hsa_circ_0101119 facilitates the progression of cervical cancer via an interaction with EIF4A3 to inhibit TCEAL6 expression.
Title: hsa_circ_0101119 facilitates the progression of cervical cancer via an interaction with EIF4A3 to inhibit TCEAL6 expression.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription elongation factor A protein-like 6

Names: TCEA-like protein 6; transcription elongation factor A (SII)-like 3; transcription elongation factor A (SII)-like 6; transcription elongation factor S-II protein-like 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001006938.3 → NP_001006939.2 transcription elongation factor A protein-like 6 isoform 2

See identical proteins and their annotated locations for NP_001006939.2

Status: VALIDATED

Source sequence(s)

Z70719

Conserved Domains (2) summary

pfam04538
Location:72 → 173

BEX; Brain expressed X-linked like family

pfam15724
Location:27 → 94

TMEM119; TMEM119 family
NM_001367790.1 → NP_001354719.1 transcription elongation factor A protein-like 6 isoform 1

Status: VALIDATED

Source sequence(s)

Z70719

UniProtKB/Swiss-Prot

Q5H9J8, Q6IPX3