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Idh1 isocitrate dehydrogenase 1 (NADP+), soluble [ Mus musculus (house mouse) ]

Gene ID: 15926, updated on 5-Jul-2021

Summary

Official Symbol
Idh1provided by MGI
Official Full Name
isocitrate dehydrogenase 1 (NADP+), solubleprovided by MGI
Primary source
MGI:MGI:96413
See related
Ensembl:ENSMUSG00000025950
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ID; Id-; Id-1; Idh-; Idpc; Idh-1; AI314845; AI788952; E030024J03Rik
Expression
Ubiquitous expression in kidney adult (RPKM 104.0), CNS E18 (RPKM 83.7) and 25 other tissues See more
Orthologs
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Genomic context

See Idh1 in Genome Data Viewer
Location:
1 C2- C3; 1 32.91 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (65197775..65225638, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (65158616..65186479, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (65205190..65233053, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D630023F18 gene Neighboring gene crystallin, gamma A Neighboring gene predicted gene, 36358 Neighboring gene phosphoinositide kinase, FYVE type zinc finger containing Neighboring gene parathyroid hormone 2 receptor

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC115782

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
 
enables NADP binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables isocitrate dehydrogenase (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables isocitrate dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables isocitrate dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
 
enables isocitrate dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
isocitrate dehydrogenase [NADP] cytoplasmic
Names
IDH
IDP
NADP(+)-specific ICDH
cytosolic NADP-isocitrate dehydrogenase
oxalosuccinate decarboxylase
NP_001104790.1
NP_034627.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111320.1NP_001104790.1  isocitrate dehydrogenase [NADP] cytoplasmic

    See identical proteins and their annotated locations for NP_001104790.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK167158, BY787507, CF379827, CF950262
    Consensus CDS
    CCDS15016.1
    UniProtKB/Swiss-Prot
    O88844
    Related
    ENSMUSP00000127307.2, ENSMUST00000169032.8
    Conserved Domains (1) summary
    PTZ00435
    Location:1411
    PTZ00435; isocitrate dehydrogenase; Provisional
  2. NM_010497.3NP_034627.3  isocitrate dehydrogenase [NADP] cytoplasmic

    See identical proteins and their annotated locations for NP_034627.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK167158, BB868400, CF379827
    Consensus CDS
    CCDS15016.1
    UniProtKB/Swiss-Prot
    O88844
    Related
    ENSMUSP00000095316.5, ENSMUST00000097709.11
    Conserved Domains (1) summary
    PTZ00435
    Location:1411
    PTZ00435; isocitrate dehydrogenase; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    65197775..65225638 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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