U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ifi47 interferon gamma inducible protein 47 [ Mus musculus (house mouse) ]

Gene ID: 15953, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Ifi47provided by MGI
Official Full Name
interferon gamma inducible protein 47provided by MGI
Primary source
MGI:MGI:99448
See related
Ensembl:ENSMUSG00000078920 AllianceGenome:MGI:99448
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Igrd; Irgd; 47kDa; Iigp4; Iipg4; IRG-47; Ifggc1
Summary
Predicted to enable GTPase activity. Acts upstream of or within defense response. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in alimentary system; axial skeleton; and liver. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E18 (RPKM 10.2), large intestine adult (RPKM 9.9) and 18 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
11 B1.2; 11 29.08 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (48967414..48987814)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (49076587..49096987)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene T cell specific GTPase 2 Neighboring gene predicted gene 12187 Neighboring gene STARR-positive B cell enhancer ABC_E8399 Neighboring gene Uncharacterized LOC133624656 Neighboring gene STARR-positive B cell enhancer ABC_E3946 Neighboring gene predicted gene 12188 Neighboring gene predicted gene, 51892 Neighboring gene olfactory receptor family 2 subfamily V member 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A promoter ISRE and dual 5' YY1 motifs control IFN-gamma induction of the IRG-47 G-protein gene. Gilly M, et al. Gene, 1996 Nov 14. PMID 8972906
  2. The IRG-47 gene is IFN-gamma induced in B cells and encodes a protein with GTP-binding motifs. Gilly M, et al. J Immunol, 1992 May 15. PMID 1578148
  3. Impaired macrophage function underscores susceptibility to Salmonella in mice lacking Irgm1 (LRG-47). Henry SC, et al. J Immunol, 2007 Nov 15. PMID 17982087
  4. p47 GTPases regulate Toxoplasma gondii survival in activated macrophages. Butcher BA, et al. Infect Immun, 2005 Jun. PMID 15908352, Free PMC Article
  5. Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection. Collazo CM, et al. J Exp Med, 2001 Jul 16. PMID 11457893, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to interferon-beta IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within defense response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum TAS
Traceable Author Statement
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
interferon gamma inducible protein 47
Names
Immunity related GTPase family D
interferon gamma inducible protein, 47 kDa
interferon-gamma-inducible GTPase Ifggc1 protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271676.1 → NP_001258605.1  interferon gamma inducible protein 47

    See identical proteins and their annotated locations for NP_001258605.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL645688
    Consensus CDS
    CCDS24595.1
    UniProtKB/TrEMBL
    A0A1G5SK64, Q3U0K0, Q61635
    Conserved Domains (2) summary
    cd04104
    Location:75 → 270
    p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1
    pfam05049
    Location:40 → 414
    IIGP; Interferon-inducible GTPase (IIGP)

  2. NM_001271677.1 → NP_001258606.1  interferon gamma inducible protein 47

    See identical proteins and their annotated locations for NP_001258606.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BU696734, CD742161, M63630
    Consensus CDS
    CCDS24595.1
    UniProtKB/TrEMBL
    A0A1G5SK64, Q3U0K0, Q61635
    Related
    ENSMUSP00000104825.2, ENSMUST00000109202.3
    Conserved Domains (2) summary
    cd04104
    Location:75 → 270
    p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1
    pfam05049
    Location:40 → 414
    IIGP; Interferon-inducible GTPase (IIGP)

  3. NM_008330.2 → NP_032356.1  interferon gamma inducible protein 47

    See identical proteins and their annotated locations for NP_032356.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BY159742, CD742161, M63630
    Consensus CDS
    CCDS24595.1
    UniProtKB/TrEMBL
    A0A1G5SK64, Q3U0K0, Q61635
    Related
    ENSMUSP00000041975.7, ENSMUST00000046704.7
    Conserved Domains (2) summary
    cd04104
    Location:75 → 270
    p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1
    pfam05049
    Location:40 → 414
    IIGP; Interferon-inducible GTPase (IIGP)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    48967414..48987814
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous