Igfbp1 insulin-like growth factor binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Igfbp1provided by MGI
Official Full Name: insulin-like growth factor binding protein 1provided by MGI
Primary source: MGI:MGI:96436
See related: Ensembl:ENSMUSG00000020429 AllianceGenome:MGI:96436
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables insulin-like growth factor binding activity. Predicted to be involved in regulation of insulin-like growth factor receptor signaling pathway. Located in extracellular space. Is expressed in several structures, including blastocyst; early embryo; liver; and secondary oocyte. Human ortholog(s) of this gene implicated in diabetic angiopathy. Orthologous to human IGFBP1 (insulin like growth factor binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward liver E18 (RPKM 581.5) See more
Orthologs: human all
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Genomic context

Location:: 11 A1; 11 4.75 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (7147787..7152546)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (7197787..7202546)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tumor-derived insulin-like growth factor-binding protein-1 contributes to resistance of hepatocellular carcinoma to tyrosine kinase inhibitors.
Title: Tumor-derived insulin-like growth factor-binding protein-1 contributes to resistance of hepatocellular carcinoma to tyrosine kinase inhibitors.
IGFBP1 Sustains Cell Survival during Spatially-Confined Migration and Promotes Tumor Metastasis.
Title: IGFBP1 Sustains Cell Survival during Spatially-Confined Migration and Promotes Tumor Metastasis.
HBP1 inhibits the development of type 2 diabetes mellitus through transcriptional activation of the IGFBP1 gene.
Title: HBP1 inhibits the development of type 2 diabetes mellitus through transcriptional activation of the IGFBP1 gene.
Sex-Specific Control of Muscle Mass: Elevated IGFBP Proteolysis and Reductions of IGF-1 Levels Are Associated with Substantial Loss of Carcass Weight in Male DU6PxIGFBP-2 Transgenic Mice.
Title: Sex-Specific Control of Muscle Mass: Elevated IGFBP Proteolysis and Reductions of IGF-1 Levels Are Associated with Substantial Loss of Carcass Weight in Male DU6PxIGFBP-2 Transgenic Mice.
In inflamed experimental autoimmune encephalomyelitis (EAE) spinal cord, study found a significant increased number of IGF-I expressing neurons versus a reduced number of IGFBP-1 positive neurons. Moreover, while nearly all IGF-I neurons expressed GSK3beta, some expressed it more intensely.
Title: Altered expression of IGF-I system in neurons of the inflamed spinal cord during acute experimental autoimmune encephalomyelitis.
the hepatokine IGFBP1 is a critical liver-bone hormonal relay that promotes osteoclastogenesis and bone resorption as well as an essential mediator of FGF21-induced bone loss
Title: A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption.
Data suggest expression of Igfbp1 in liver is regulated by dietary factors; carnosine supplementation down-regulates expression of Igfbp1 in liver of obese/diabetic mice; mechanism involves suppression of Hif1a (hypoxia inducible factor 1 alpha).
Title: Carnosine decreases IGFBP1 production in db/db mice through suppression of HIF-1.
serum IGFBPI protein could provide an easily measured biomarker for early detection of alcohol-induced liver injury in humans
Title: Identification of serum insulin-like growth factor binding protein 1 as diagnostic biomarker for early-stage alcohol-induced liver disease.
During the two week starvation period, both the levels of plasma IGF-1 and IGFBP-1 decreased.
Title: [Effects of compensatory growth on the levels of IGF-1, IGFBP-1 and expressions of IGF-1 mRNA, IGF-1R mRNA in Carassius auratus gibelio].
These results show that RTEF-1-stimulated IGFBP-1 expression may be central to the mechanism by which RTEF-1 attenuates blood glucose levels.
Title: RTEF-1 attenuates blood glucose levels by regulating insulin-like growth factor binding protein-1 in the endothelium.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Igfbp1 (e-PCR), detects polymorphism
- UniSTS:471312

Igfbp1 (e-PCR), detects polymorphism
- UniSTS:461919

Igfbp1 (e-PCR), detects polymorphism
- UniSTS:474723

Igfbp1 (e-PCR), detects polymorphism
- UniSTS:516199

Igfbp1 (e-PCR), detects polymorphism
- UniSTS:143486

PMC141131P1 (e-PCR)
- UniSTS:270986

Igfbp1 (e-PCR), detects polymorphism
- UniSTS:525989

X81579 (e-PCR)
- UniSTS:163493

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables growth factor binding	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor I binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor I binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor II binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor II binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of insulin-like growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to insulin	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: insulin-like growth factor-binding protein 1

Names: IBP-1; IGF-binding protein 1; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1 PRECURSOR (IGFBP-1) (IBP-1) (IGF-BINDING PROTEIN 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.