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Ccn1 cellular communication network factor 1 [ Mus musculus (house mouse) ]

Gene ID: 16007, updated on 15-Jun-2021

Summary

Official Symbol
Ccn1provided by MGI
Official Full Name
cellular communication network factor 1provided by MGI
Primary source
MGI:MGI:88613
See related
Ensembl:ENSMUSG00000028195
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CCN; Cyr6; Cyr61; Igfbp10; AI325051
Expression
Broad expression in lung adult (RPKM 41.5), limb E14.5 (RPKM 37.8) and 26 other tissues See more
Orthologs
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Genomic context

See Ccn1 in Genome Data Viewer
Location:
3 H2; 3 70.18 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (145352726..145355740, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (145646971..145649985, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (145309935..145312949, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene zinc finger, HIT type 6 Neighboring gene predicted gene, 40164 Neighboring gene predicted gene, 17501 Neighboring gene dimethylarginine dimethylaminohydrolase 1 Neighboring gene ribosomal protein L36A, pseudogene 2 Neighboring gene predicted gene, 35187

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix binding IDA
Inferred from Direct Assay
more info
PubMed 
enables growth factor binding IEA
Inferred from Electronic Annotation
more info
 
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables insulin-like growth factor binding IEA
Inferred from Electronic Annotation
more info
 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables integrin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process involved in heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within atrial septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within atrioventricular valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chondroblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within chorio-allantoic fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within extracellular matrix organization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within intussusceptive angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within labyrinthine layer blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell death IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within osteoblast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cartilage development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell-substrate adhesion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of ceramide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of osteoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of phospholipase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within reactive oxygen species metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within ventricular septum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in wound healing, spreading of cells ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CCN family member 1
Names
3CH61
IBP-10
IGF-binding protein 10
IGFBP-10
cysteine rich protein 61
cysteine-rich angiogenic inducer 61
insulin-like growth factor-binding protein 10
intermediate early
protein CYR61

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010516.2NP_034646.1  CCN family member 1 precursor

    See identical proteins and their annotated locations for NP_034646.1

    Status: VALIDATED

    Source sequence(s)
    AC136729, AK159452
    Consensus CDS
    CCDS17895.1
    UniProtKB/Swiss-Prot
    P18406
    UniProtKB/TrEMBL
    Q3TX21
    Related
    ENSMUSP00000029846.4, ENSMUST00000029846.5
    Conserved Domains (4) summary
    smart00209
    Location:230270
    TSP1; Thrombospondin type 1 repeats
    smart00214
    Location:100159
    VWC; von Willebrand factor (vWF) type C domain
    pfam00007
    Location:291373
    Cys_knot; Cystine-knot domain
    pfam00219
    Location:2678
    IGFBP; Insulin-like growth factor binding protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    145352726..145355740 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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