Ccn1 cellular communication network factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccn1provided by MGI
Official Full Name: cellular communication network factor 1provided by MGI
Primary source: MGI:MGI:88613
See related: Ensembl:ENSMUSG00000028195 AllianceGenome:MGI:88613
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cyr61; Igfbp10
Summary: Enables extracellular matrix binding activity and integrin binding activity. Acts upstream of or within several processes, including circulatory system development; positive regulation of hydrolase activity; and regulation of apoptotic process. Located in collagen-containing extracellular matrix. Is expressed in several structures, including brain; cardiovascular system; embryo mesenchyme; sensory organ; and skeleton. Used to study atrial heart septal defect 1 and atrioventricular septal defect. Orthologous to human CCN1 (cellular communication network factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 41.5), limb E14.5 (RPKM 37.8) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 H2; 3 70.18 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (145352726..145355740, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (145646971..145649985, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatocyte CYR61 polarizes profibrotic macrophages to orchestrate NASH fibrosis.
Title: Hepatocyte CYR61 polarizes profibrotic macrophages to orchestrate NASH fibrosis.
CCN1 expression is regulated by mechanical stimuli in tendons.
Title: CCN1 expression is regulated by mechanical stimuli in tendons.
[Effect of Cyr61 on Imatinib Resistance in Chronic Myeloid Leukemia and Its Mechanism].
Title: [Effect of Cyr61 on Imatinib Resistance in Chronic Myeloid Leukemia and Its Mechanism].
Matrix-bound Cyr61/CCN1 is required to retain the properties of the bone marrow mesenchymal stem cell niche but is depleted with aging.
Title: Matrix-bound Cyr61/CCN1 is required to retain the properties of the bone marrow mesenchymal stem cell niche but is depleted with aging.
Effects of umbilical cord mesenchymal stem cells on expression of CYR61, FSH, and AMH in mice with premature ovarian failure.
Title: Effects of umbilical cord mesenchymal stem cells on expression of CYR61, FSH, and AMH in mice with premature ovarian failure.
CCN1 interacts with integrins to regulate intestinal stem cell proliferation and differentiation.
Title: CCN1 interacts with integrins to regulate intestinal stem cell proliferation and differentiation.
CCN1 Promotes Inflammation by Inducing IL-6 Production via alpha6beta1/PI3K/Akt/NF-kappaB Pathway in Autoimmune Hepatitis.
Title: CCN1 Promotes Inflammation by Inducing IL-6 Production via α6β1/PI3K/Akt/NF-κB Pathway in Autoimmune Hepatitis.
Endothelial cyclin I reduces vulnerability to angiotensin II-induced vascular remodeling and abdominal aortic aneurysm risk.
Title: Endothelial cyclin I reduces vulnerability to angiotensin II-induced vascular remodeling and abdominal aortic aneurysm risk.
Expression of Cyr61 in ApoE(-/-) mice with chronic unilateral renal artery ligation.
Title: Expression of Cyr61 in ApoE(-/-) mice with chronic unilateral renal artery ligation.
CCN1/Cyr61 Is Required in Osteoblasts for Responsiveness to the Anabolic Activity of PTH.
Title: CCN1/Cyr61 Is Required in Osteoblasts for Responsiveness to the Anabolic Activity of PTH.

Submit: New GeneRIF Correction See all GeneRIFs (82)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI325051 (e-PCR)
- UniSTS:178949

Cyr61 (e-PCR), detects polymorphism
- UniSTS:532670

Cyr61 (e-PCR), detects polymorphism
- UniSTS:506833

D3Mit113 (e-PCR), detects polymorphism
- UniSTS:129516

D3Mit113.1 (e-PCR), detects polymorphism
- UniSTS:129517

D3Mit113.2 (e-PCR), detects polymorphism
- UniSTS:129518

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables extracellular matrix binding	IDA Inferred from Direct Assay more info	PubMed
enables growth factor binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within apoptotic process involved in heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within atrial septum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within atrioventricular valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of chondroblast differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within chondroblast differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within chorio-allantoic fusion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within extracellular matrix organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within intussusceptive angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within labyrinthine layer blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within osteoblast differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell-substrate adhesion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of ceramide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of phospholipase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor (ligand) superfamily member 11 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within reactive oxygen species metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ventricular septum development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing, spreading of cells	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CCN family member 1

Names: 3CH61; IBP-10; IGF-binding protein 10; IGFBP-10; cysteine rich protein 61; cysteine-rich angiogenic inducer 61; insulin-like growth factor-binding protein 10; intermediate early; protein CYR61

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010516.2 → NP_034646.1 CCN family member 1 precursor

See identical proteins and their annotated locations for NP_034646.1

Status: VALIDATED

Source sequence(s)

AC136729, AK159452

Consensus CDS

CCDS17895.1

UniProtKB/Swiss-Prot

P18406

UniProtKB/TrEMBL

Q3TX21

Related

ENSMUSP00000029846.4, ENSMUST00000029846.5

Conserved Domains (4) summary

smart00209
Location:230 → 270

TSP1; Thrombospondin type 1 repeats

smart00214
Location:100 → 159

VWC; von Willebrand factor (vWF) type C domain

pfam00007
Location:291 → 373

Cys_knot; Cystine-knot domain

pfam00219
Location:26 → 78

IGFBP; Insulin-like growth factor binding protein