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Igfbp2 insulin-like growth factor binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 16008, updated on 23-Jun-2021

Summary

Official Symbol
Igfbp2provided by MGI
Official Full Name
insulin-like growth factor binding protein 2provided by MGI
Primary source
MGI:MGI:96437
See related
Ensembl:ENSMUSG00000039323
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IBP-2; IGFBP; Igfbp-2; AI255832; mIGFBP-2
Summary
The protein encoded by this gene is one of several similar proteins that bind insulin-like growth factors I and II (Igf-I and Igf-II). The encoded protein can be secreted into the bloodstream, where it binds Igf-I and Igf-II with high affinity, or it can remain intracellular, interacting with many different ligands. Two transcript variants, one encoding a secreted isoform and the other encoding a nonsecreted isoform, have been found for this gene. [provided by RefSeq, Sep 2015]
Expression
Biased expression in bladder adult (RPKM 311.4), liver E18 (RPKM 285.8) and 12 other tissues See more
Orthologs
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Genomic context

See Igfbp2 in Genome Data Viewer
Location:
1 C3; 1 36.94 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (72863639..72891633)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (72824480..72852474)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (72871078..72899048)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51632 Neighboring gene predicted gene, 39663 Neighboring gene predicted gene, 30788 Neighboring gene predicted gene, 30847 Neighboring gene predicted gene, 53254 Neighboring gene insulin-like growth factor binding protein 5 Neighboring gene ribosomal protein L7A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables growth factor binding IEA
Inferred from Electronic Annotation
more info
 
enables insulin-like growth factor I binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables insulin-like growth factor I binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin-like growth factor II binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables insulin-like growth factor II binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin-like growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
insulin-like growth factor-binding protein 2
Names
IGF-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310659.1NP_001297588.1  insulin-like growth factor-binding protein 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate first exon compared to variant 1, which results in translation initiation from a downstream AUG. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC115870, AC121498
    Consensus CDS
    CCDS78613.1
    UniProtKB/TrEMBL
    D3YU40
    Related
    ENSMUSP00000112706.2, ENSMUST00000120564.2
    Conserved Domains (1) summary
    pfam00086
    Location:60139
    Thyroglobulin_1; Thyroglobulin type-1 repeat
  2. NM_008342.3NP_032368.2  insulin-like growth factor-binding protein 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_032368.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC121498, AI159675, AK012703, DV552718
    Consensus CDS
    CCDS15036.1
    UniProtKB/Swiss-Prot
    P47877
    Related
    ENSMUSP00000046610.5, ENSMUST00000047328.11
    Conserved Domains (2) summary
    smart00121
    Location:38116
    IB; Insulin growth factor-binding protein homologues
    pfam00086
    Location:207286
    Thyroglobulin_1; Thyroglobulin type-1 repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    72863639..72891633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250357.2XP_030106217.1  insulin-like growth factor-binding protein 2 isoform X1

    Conserved Domains (1) summary
    pfam00086
    Location:60139
    Thyroglobulin_1; Thyroglobulin type-1 repeat
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