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Igfbp3 insulin-like growth factor binding protein 3 [ Mus musculus (house mouse) ]

Gene ID: 16009, updated on 29-Jun-2021

Summary

Official Symbol
Igfbp3provided by MGI
Official Full Name
insulin-like growth factor binding protein 3provided by MGI
Primary source
MGI:MGI:96438
See related
Ensembl:ENSMUSG00000020427
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IGFBP; IGFBP-3; IGgfbp3; AI649005
Expression
Broad expression in kidney adult (RPKM 114.2), limb E14.5 (RPKM 82.6) and 23 other tissues See more
Orthologs
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Genomic context

See Igfbp3 in Genome Data Viewer
Location:
11 A1; 11 4.75 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (7156086..7165498, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (7206086..7215498, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (7106089..7113926, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene coiled coil domain 201 Neighboring gene insulin-like growth factor binding protein 1 Neighboring gene predicted gene, 36565 Neighboring gene predicted gene, 36653

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables fibronectin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fibronectin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables growth factor binding IEA
Inferred from Electronic Annotation
more info
 
enables insulin-like growth factor I binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables insulin-like growth factor I binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin-like growth factor II binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables insulin-like growth factor II binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin-like growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine phosphatase activator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of testosterone secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within osteoblast differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within positive regulation of MAPK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of apoptotic DNA fragmentation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of insulin-like growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within regulation of cell growth IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of glucose metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of growth IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of insulin-like growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within type B pancreatic cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in heterochromatin ISO
Inferred from Sequence Orthology
more info
 
part_of insulin-like growth factor binary complex ISO
Inferred from Sequence Orthology
more info
 
part_of insulin-like growth factor ternary complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in platelet alpha granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
insulin-like growth factor-binding protein 3
Names
IBP-3
IGF-binding protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008343.2NP_032369.2  insulin-like growth factor-binding protein 3 precursor

    See identical proteins and their annotated locations for NP_032369.2

    Status: VALIDATED

    Source sequence(s)
    AK141690, AL607124, BP754524
    Consensus CDS
    CCDS24428.1
    UniProtKB/Swiss-Prot
    P47878
    UniProtKB/TrEMBL
    Q3UR87
    Related
    ENSMUSP00000020702.5, ENSMUST00000020702.11
    Conserved Domains (3) summary
    smart00121
    Location:39117
    IB; Insulin growth factor-binding protein homologues
    pfam00086
    Location:214286
    Thyroglobulin_1; Thyroglobulin type-1 repeat
    cl00349
    Location:137186
    S15_NS1_EPRS_RNA-bind; S15/NS1/EPRS_RNA-binding domain. This short domain consists of a helix-turn-helix structure, which can bind to several types of RNA. It is found in the ribosomal protein S15, the influenza A viral nonstructural protein (NSA) and in several eukaryotic ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    7156086..7165498 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243665.3XP_011241967.1  insulin-like growth factor-binding protein 3 isoform X1

    Conserved Domains (3) summary
    smart00121
    Location:2285
    IB; Insulin growth factor-binding protein homologues
    pfam00086
    Location:182254
    Thyroglobulin_1; Thyroglobulin type-1 repeat
    cl00349
    Location:105154
    S15_NS1_EPRS_RNA-bind; S15/NS1/EPRS_RNA-binding domain. This short domain consists of a helix-turn-helix structure, which can bind to several types of RNA. It is found in the ribosomal protein S15, the influenza A viral nonstructural protein (NSA) and in several eukaryotic ...
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