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Ighm immunoglobulin heavy constant mu [ Mus musculus (house mouse) ]

Gene ID: 16019, updated on 11-May-2021

Summary

Official Symbol
Ighmprovided by MGI
Official Full Name
immunoglobulin heavy constant muprovided by MGI
Primary source
MGI:MGI:96448
See related
Ensembl:ENSMUSG00000076617 IMGT/GENE-DB:IGHM
Gene type
other
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ig; Igm; muH; Igh-; Igh6; Igh-6; Igh-M; AI326478
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Genomic context

See Ighm in Genome Data Viewer
Location:
12 F1; 12 62.1 cM
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (113382446..113386350, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (113418826..113422730, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (114657037..114660941, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene immunoglobulin heavy chain complex Neighboring gene transducin-like enhancer of split 6 pseudogene Neighboring gene transducin-like enhancer of split 6 pseudogene Neighboring gene immunoglobulin heavy joining 4 Neighboring gene immunoglobulin heavy joining 3 Neighboring gene immunoglobulin heavy constant delta

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Other Names

  • Ig mu
  • immunoglobulin heavy chain 6 (heavy chain of IgM)
  • mu-immunoglobulin

Clone Names

  • MGC107036, MGC107507

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables antigen binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables immunoglobulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables immunoglobulin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell affinity maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within B cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within antigen processing and presentation IDA
Inferred from Direct Assay
more info
 
involved_in complement activation, classical pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within early endosome to late endosome transport IDA
Inferred from Direct Assay
more info
 
acts_upstream_of_or_within humoral immune response mediated by circulating immunoglobulin IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within immunoglobulin mediated immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phagocytosis, engulfment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phagocytosis, recognition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of B cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of B cell activation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of B cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of endocytosis IDA
Inferred from Direct Assay
more info
 
acts_upstream_of_or_within positive regulation of immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of immunoglobulin production IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of B cell receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
part_of immunoglobulin complex, circulating IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of immunoglobulin complex, circulating IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_005838.1 

    Range
    171230..175134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    113382446..113386350 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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