U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LDHAL6A lactate dehydrogenase A like 6A [ Homo sapiens (human) ]

Gene ID: 160287, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
LDHAL6Aprovided by HGNC
Official Full Name
lactate dehydrogenase A like 6Aprovided by HGNC
Primary source
HGNC:HGNC:28335
See related
Ensembl:ENSG00000166800 MIM:618928; AllianceGenome:HGNC:28335
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LDH6A
Summary
Predicted to enable L-lactate dehydrogenase activity. Predicted to be involved in carbohydrate metabolic process and carboxylic acid metabolic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 3.4) and thyroid (RPKM 0.2) See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LDHAL6A in Genome Data Viewer
Location:
11p15.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (18455856..18479601)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (18553931..18577621)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (18477403..18501148)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:18416070-18416735 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3191 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:18417470-18417971 Neighboring gene lactate dehydrogenase A Neighboring gene lactate dehydrogenase C Neighboring gene ReSE screen-validated silencer GRCh37_chr11:18507685-18507894 Neighboring gene tumor susceptibility 101 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4502 Neighboring gene UEV and lactate/malate dehyrogenase domains Neighboring gene ReSE screen-validated silencer GRCh37_chr11:18600575-18600756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4503 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4504 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4505 Neighboring gene Sharpr-MPRA regulatory region 13786

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of a novel human lactate dehydrogenase gene LDHAL6A, which activates transcriptional activities of AP1(PMA). Chen X, et al. Mol Biol Rep, 2009 Apr. PMID 18351441
  2. Huntingtin interacting proteins are genetic modifiers of neurodegeneration. Kaltenbach LS, et al. PLoS Genet, 2007 May 11. PMID 17500595, Free PMC Article
  3. ∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis. Pankow S, et al. Nature, 2015 Dec 24. PMID 26618866, Free PMC Article
  4. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
  5. A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling. Malty RH, et al. Cell Syst, 2017 Dec 27. PMID 29128334, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. expression of LDHAL6A was able to activate transcriptional activities of AP1(PMA)
    Title: Identification of a novel human lactate dehydrogenase gene LDHAL6A, which activates transcriptional activities of AP1(PMA).
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC23940

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-lactate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-lactate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in lactate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyruvate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
L-lactate dehydrogenase A-like 6A
Names
LDHA-like protein 6A
NP_001137543.1
NP_659409.2
XP_005252862.2
XP_011518224.2
XP_011518225.1
XP_011518226.1
XP_011518227.1
XP_054223838.1
XP_054223839.1
XP_054223840.1
XP_054223841.1
XP_054223842.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144071.2 → NP_001137543.1  L-lactate dehydrogenase A-like 6A

    See identical proteins and their annotated locations for NP_001137543.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AC027544, AY581313
    Consensus CDS
    CCDS7841.1
    UniProtKB/Swiss-Prot
    D3DQY5, Q6ZMR3
    Related
    ENSP00000379516.3, ENST00000396213.7
    Conserved Domains (1) summary
    cd05293
    Location:19 → 329
    LDH_1; A subgroup of L-lactate dehydrogenases

  2. NM_144972.5 → NP_659409.2  L-lactate dehydrogenase A-like 6A

    See identical proteins and their annotated locations for NP_659409.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC027544, AY581313
    Consensus CDS
    CCDS7841.1
    UniProtKB/Swiss-Prot
    D3DQY5, Q6ZMR3
    Related
    ENSP00000280706.2, ENST00000280706.3
    Conserved Domains (1) summary
    cd05293
    Location:19 → 329
    LDH_1; A subgroup of L-lactate dehydrogenases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    18455856..18479601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519923.3 → XP_011518225.1  L-lactate dehydrogenase A-like 6A isoform X3

    See identical proteins and their annotated locations for XP_011518225.1

    Conserved Domains (2) summary
    cd05293
    Location:19 → 347
    LDH_1; A subgroup of L-lactate dehydrogenases
    TIGR01771
    Location:25 → 343
    L-LDH-NAD; L-lactate dehydrogenase

  2. XM_011519922.3 → XP_011518224.2  L-lactate dehydrogenase A-like 6A isoform X1

  3. XM_005252805.5 → XP_005252862.2  L-lactate dehydrogenase A-like 6A isoform X2

    Conserved Domains (2) summary
    cd05293
    Location:43 → 353
    LDH_1; A subgroup of L-lactate dehydrogenases
    TIGR01771
    Location:49 → 349
    L-LDH-NAD; L-lactate dehydrogenase

  4. XM_011519925.2 → XP_011518227.1  L-lactate dehydrogenase A-like 6A isoform X3

    See identical proteins and their annotated locations for XP_011518227.1

    Conserved Domains (2) summary
    cd05293
    Location:19 → 347
    LDH_1; A subgroup of L-lactate dehydrogenases
    TIGR01771
    Location:25 → 343
    L-LDH-NAD; L-lactate dehydrogenase

  5. XM_011519924.3 → XP_011518226.1  L-lactate dehydrogenase A-like 6A isoform X3

    See identical proteins and their annotated locations for XP_011518226.1

    Conserved Domains (2) summary
    cd05293
    Location:19 → 347
    LDH_1; A subgroup of L-lactate dehydrogenases
    TIGR01771
    Location:25 → 343
    L-LDH-NAD; L-lactate dehydrogenase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    18553931..18577621
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367865.1 → XP_054223840.1  L-lactate dehydrogenase A-like 6A isoform X3

  2. XM_054367863.1 → XP_054223838.1  L-lactate dehydrogenase A-like 6A isoform X1

  3. XM_054367864.1 → XP_054223839.1  L-lactate dehydrogenase A-like 6A isoform X2

  4. XM_054367867.1 → XP_054223842.1  L-lactate dehydrogenase A-like 6A isoform X3

  5. XM_054367866.1 → XP_054223841.1  L-lactate dehydrogenase A-like 6A isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZMR3.1 GenPept UniProtKB/Swiss-Prot:Q6ZMR3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous