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Jchain immunoglobulin joining chain [ Mus musculus (house mouse) ]

Gene ID: 16069, updated on 6-May-2021

Summary

Official Symbol
Jchainprovided by MGI
Official Full Name
immunoglobulin joining chainprovided by MGI
Primary source
MGI:MGI:96493
See related
Ensembl:ENSMUSG00000067149
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ig; Igj; Jch; AI323815; 9530090F24Rik
Expression
Biased expression in large intestine adult (RPKM 384.0), small intestine adult (RPKM 358.4) and 3 other tissues See more
Orthologs
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Genomic context

See Jchain in Genome Data Viewer
Location:
5; 5 E1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (88667668..88675756, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (88519809..88527897, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (88948834..88956922, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ameloblastin Neighboring gene enamelin Neighboring gene UTP3 small subunit processome component Neighboring gene predicted gene, 42107 Neighboring gene RUN and FYVE domain containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables IgA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables IgA binding ISO
Inferred from Sequence Orthology
more info
 
enables antigen binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
contributes_to immunoglobulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to immunoglobulin receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to immunoglobulin receptor binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to peptidoglycan binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to phosphatidylcholine binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in adaptive immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in antibacterial humoral response ISO
Inferred from Sequence Orthology
more info
 
involved_in glomerular filtration ISO
Inferred from Sequence Orthology
more info
 
involved_in humoral immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within humoral immune response ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of respiratory burst ISO
Inferred from Sequence Orthology
more info
 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of dimeric IgA immunoglobulin complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of dimeric IgA immunoglobulin complex ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of monomeric IgA immunoglobulin complex ISO
Inferred from Sequence Orthology
more info
 
part_of pentameric IgM immunoglobulin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of pentameric IgM immunoglobulin complex ISO
Inferred from Sequence Orthology
more info
 
part_of secretory IgA immunoglobulin complex ISO
Inferred from Sequence Orthology
more info
 
part_of secretory dimeric IgA immunoglobulin complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
immunoglobulin J chain
Names
J chain
immunoglobulin joining gene (not J region)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152839.3NP_690052.2  immunoglobulin J chain precursor

    See identical proteins and their annotated locations for NP_690052.2

    Status: VALIDATED

    Source sequence(s)
    AA254605, AC121585, AK078865, AK160344, BG147365
    Consensus CDS
    CCDS19401.1
    UniProtKB/Swiss-Prot
    P01592
    Related
    ENSMUSP00000084259.4, ENSMUST00000087033.6
    Conserved Domains (1) summary
    pfam15097
    Location:23159
    Ig_J_chain; Immunoglobulin J chain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    88667668..88675756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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