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Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) [ Mus musculus (house mouse) ]

Gene ID: 16149, updated on 3-Aug-2021

Summary

Official Symbol
Cd74provided by MGI
Official Full Name
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)provided by MGI
Primary source
MGI:MGI:96534
See related
Ensembl:ENSMUSG00000024610
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C; Ii; CLIP; DHLAG; HLADG; Ia-GAMMA
Expression
Biased expression in spleen adult (RPKM 2800.7), large intestine adult (RPKM 1812.1) and 12 other tissues See more
Orthologs
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Genomic context

See Cd74 in Genome Data Viewer
Location:
18 E1; 18 34.41 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (60936921..60945724)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (60803849..60812652)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (60963503..60972306)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S14 Neighboring gene 40S ribosomal protein S16 pseudogene Neighboring gene microRNA 5107 Neighboring gene treacle ribosome biogenesis factor 1 Neighboring gene predicted gene, 41744

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CD4 receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables MHC class II protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MHC class II protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables MHC class II protein binding, via antigen binding groove ISO
Inferred from Sequence Orthology
more info
 
enables MHC class II protein complex binding ISO
Inferred from Sequence Orthology
more info
 
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to cytokine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cytokine binding ISO
Inferred from Sequence Orthology
more info
 
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cytokine receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables macrophage migration inhibitory factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables macrophage migration inhibitory factor binding ISO
Inferred from Sequence Orthology
more info
 
enables nitric-oxide synthase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein folding chaperone ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in T cell activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in antigen processing and presentation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within antigen processing and presentation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within antigen processing and presentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chaperone cofactor-dependent protein refolding IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within chaperone cofactor-dependent protein refolding IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within defense response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immunoglobulin mediated immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular protein transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in macrophage migration inhibitory factor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mature B cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of peptide secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of viral entry into host cell ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative thymic T cell selection IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of adaptive immune response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cytokine-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendritic cell antigen processing and presentation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of innate immune response IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of macrophage cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of macrophage migration inhibitory factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of monocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neutrophil chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of prostaglandin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type 2 immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of type 2 immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of viral entry into host cell ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive thymic T cell selection IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in prostaglandin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein trimerization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to interferon-gamma IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to interferon-gamma ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
part_of MHC class II protein complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of NOS2-CD74 complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in late endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of macrophage migration inhibitory factor receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of macrophage migration inhibitory factor receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in multivesicular body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in vacuole ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
H-2 class II histocompatibility antigen gamma chain
Names
HLA-DR-GAMMA
Ia-associated invariant chain
MHC class II-associated invariant chain
class II-associated invariant chain peptide
dinucleotide microsatellite
histocompatibility: class II antigens, gamma chain of
ia antigen-associated invariant chain
ii chain
invariant polypeptide of major histocompatibility complex, class II antigen-associated

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042605.1NP_001036070.1  H-2 class II histocompatibility antigen gamma chain isoform 1

    See identical proteins and their annotated locations for NP_001036070.1

    Status: VALIDATED

    Source sequence(s)
    AK002232, AW123644, BG148172
    Consensus CDS
    CCDS37835.1
    UniProtKB/Swiss-Prot
    P04441
    UniProtKB/TrEMBL
    Q3U4Q8, Q545Y5
    Related
    ENSMUSP00000095171.3, ENSMUST00000097563.9
    Conserved Domains (3) summary
    cd00191
    Location:195254
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    pfam08831
    Location:119184
    MHCassoc_trimer; Class II MHC-associated invariant chain trimerization domain
    pfam09307
    Location:1111
    MHC2-interact; CLIP, MHC2 interacting
  2. NM_010545.3NP_034675.1  H-2 class II histocompatibility antigen gamma chain isoform 2

    See identical proteins and their annotated locations for NP_034675.1

    Status: VALIDATED

    Source sequence(s)
    AK002232, AW123644
    Consensus CDS
    CCDS50299.1
    UniProtKB/TrEMBL
    Q545Y5
    Related
    ENSMUSP00000057836.9, ENSMUST00000050487.16
    Conserved Domains (2) summary
    pfam08831
    Location:119184
    MHCassoc_trimer; Class II MHC-associated invariant chain trimerization domain
    pfam09307
    Location:1111
    MHC2-interact; CLIP, MHC2 interacting

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    60936921..60945724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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