Il10ra interleukin 10 receptor, alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il10raprovided by MGI
Official Full Name: interleukin 10 receptor, alphaprovided by MGI
Primary source: MGI:MGI:96538
See related: Ensembl:ENSMUSG00000032089 AllianceGenome:MGI:96538
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Il10r; CDw210; CDw210a; IL-10R1; IL-10RA; mIL-10R
Summary: Predicted to enable interleukin-10 binding activity and interleukin-10 receptor activity. Predicted to be involved in several processes, including negative regulation of autophagy; positive regulation of receptor signaling pathway via JAK-STAT; and ubiquitin-dependent endocytosis. Predicted to be located in cytosol. Predicted to be integral component of plasma membrane. Predicted to colocalize with plasma membrane. Human ortholog(s) of this gene implicated in inflammatory bowel disease 28. Orthologous to human IL10RA (interleukin 10 receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 30.8), thymus adult (RPKM 10.6) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.2; 9 24.84 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (45165135..45180447, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (45253837..45269149, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The IL-10 receptor inhibits cell extrinsic signals necessary for STAT1-dependent macrophage accumulation during colitis.
Title: The IL-10 receptor inhibits cell extrinsic signals necessary for STAT1-dependent macrophage accumulation during colitis.
CCR2 promotes monocyte recruitment and intestinal inflammation in mice lacking the interleukin-10 receptor.
Title: CCR2 promotes monocyte recruitment and intestinal inflammation in mice lacking the interleukin-10 receptor.
Interleukin-10 receptor signaling promotes the maintenance of a PD-1(int) TCF-1(+) CD8(+) T cell population that sustains anti-tumor immunity.
Title: Interleukin-10 receptor signaling promotes the maintenance of a PD-1(int) TCF-1(+) CD8(+) T cell population that sustains anti-tumor immunity.
Loss of interleukin-10 receptor disrupts intestinal epithelial cell proliferation and skews differentiation towards the goblet cell fate.
Title: Loss of interleukin-10 receptor disrupts intestinal epithelial cell proliferation and skews differentiation towards the goblet cell fate.
Modulation of IL10 and Its Receptor Subunits in Normal and Progesterone-Prolonged Gestation in the Mouse.
Title: Modulation of IL10 and Its Receptor Subunits in Normal and Progesterone-Prolonged Gestation in the Mouse.
Blocking IL-10 receptor signaling ameliorates Mycobacterium tuberculosis infection during influenza-induced exacerbation.
Title: Blocking IL-10 receptor signaling ameliorates Mycobacterium tuberculosis infection during influenza-induced exacerbation.
The authors demonstrate here that selective loss of IL10 receptor alpha in adipocytes recapitulates the beneficial effects of global IL10 deletion, and that local crosstalk between IL10-producing immune cells and adipocytes is a determinant of thermogenesis and systemic energy balance.
Title: Single cell analysis reveals immune cell-adipocyte crosstalk regulating the transcription of thermogenic adipocytes.
In summary, our data identify the IL-10Ra on Tregs as a crucial component for control of Th17 immunity during homeostasis and after induction of acute GN.
Title: IL-10 Receptor Signaling Empowers Regulatory T Cells to Control Th17 Responses and Protect from GN.
These results indicate that IL10R-mediated regulation of macrophage function during the early postnatal period is indispensable for preventing the development of murine colitis.
Title: Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor.
cross-talk between type I IFN and IL-10R signaling pathways may represent a key host cellular mechanism to investigate further in order to unravel the balance between pathogenic inflammation and homeostasis of the colon. Taken together, our data clearly demonstrate that type I IFN signaling is pathogenic in S. typhimurium colitis
Title: Type I interferon signaling restrains IL-10R+ colonic macrophages and dendritic cells and leads to more severe Salmonella colitis.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Targeted (7) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (3) 1 citation

General gene information

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Markers

Il10ra (e-PCR), detects polymorphism
- UniSTS:143533

AW553859 (e-PCR)
- UniSTS:179890

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables interleukin-10 binding	ISO Inferred from Sequence Orthology more info
enables interleukin-10 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-10 receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in intestinal epithelial structure maintenance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse organization	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent endocytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-10 receptor subunit alpha

Names: IL-10 receptor subunit alpha; IL-10R subunit 1; IL-10R subunit alpha; interleukin-10 receptor subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001324486.1 → NP_001311415.1 interleukin-10 receptor subunit alpha isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice donor site in the 5' coding region, compared to variant 1. This difference results in a shorter isoform (2), compared to isoform 1.

Source sequence(s)

AK149680, AK149899, AK153120, BY691362

Consensus CDS

CCDS85671.1

UniProtKB/TrEMBL

H3BKN6, Q3UE89

Related

ENSMUSP00000135461.2, ENSMUST00000176222.2
NM_008348.3 → NP_032374.1 interleukin-10 receptor subunit alpha isoform 1 precursor

See identical proteins and their annotated locations for NP_032374.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK149899, AK159566, BY691362

Consensus CDS

CCDS23131.1

UniProtKB/Swiss-Prot

Q61727

UniProtKB/TrEMBL

Q3U6I9, Q3UDL4

Related

ENSMUSP00000034594.10, ENSMUST00000034594.16

Conserved Domains (2) summary

pfam01108
Location:21 → 114

Tissue_fac; Tissue factor

cl21522
Location:132 → 229

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RNA

NR_136903.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate 5' internal exon, compared to variant 1. This variant is represented as non-coding because the use of the translational start codon used in variant 1 renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). This transcript is potentially protein coding if an alternate upstream translational start codon is used.

Source sequence(s)

AK149899, AK153120, BY691362

Related

ENSMUST00000176808.2