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Il12rb1 interleukin 12 receptor, beta 1 [ Mus musculus (house mouse) ]

Gene ID: 16161, updated on 8-Nov-2022

Summary

Official Symbol
Il12rb1provided by MGI
Official Full Name
interleukin 12 receptor, beta 1provided by MGI
Primary source
MGI:MGI:104579
See related
Ensembl:ENSMUSG00000000791 AllianceGenome:MGI:104579
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD212; IL-12R[b]; IL-12R-beta-1
Summary
Contributes to cytokine binding activity. Acts upstream of or within peptidyl-tyrosine phosphorylation. Located in external side of plasma membrane. Part of interleukin-23 receptor complex. Is expressed in mandible; maxilla; orbito-sphenoid; rib; and testis. Human ortholog(s) of this gene implicated in immunodeficiency 30. Orthologous to human IL12RB1 (interleukin 12 receptor subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 9.3), spleen adult (RPKM 1.7) and 4 other tissues See more
Orthologs
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Genomic context

See Il12rb1 in Genome Data Viewer
Location:
8 B3.3; 8 34.21 cM
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71261005..71276186)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70808360..70823542)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2010320M18 gene Neighboring gene microtubule associated serine/threonine kinase 3 Neighboring gene microRNA 7240 Neighboring gene arrestin domain containing 2 Neighboring gene potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to cytokine binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to interleukin-12 receptor activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to interleukin-12 receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to interleukin-12 receptor binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to interleukin-23 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to interleukin-23 binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to interleukin-23 receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in immune response IC
Inferred by Curator
more info
PubMed 
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NK T cell proliferation IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of NK T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T-helper 1 type immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T-helper 17 type immune response IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of activated T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of defense response to virus by host ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-17 production IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of natural killer cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of interleukin-12 receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of interleukin-12 receptor complex IC
Inferred by Curator
more info
PubMed 
part_of interleukin-12 receptor complex ISO
Inferred from Sequence Orthology
more info
 
part_of interleukin-23 receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of interleukin-23 receptor complex IC
Inferred by Curator
more info
PubMed 
part_of interleukin-23 receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of interleukin-23 receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interleukin-12 receptor subunit beta-1
Names
IL-12 receptor beta component
IL-12 receptor subunit beta-1
IL-12R subunit beta-1
Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008353.3NP_032379.2  interleukin-12 receptor subunit beta-1 precursor

    See identical proteins and their annotated locations for NP_032379.2

    Status: VALIDATED

    Source sequence(s)
    AC162446
    Consensus CDS
    CCDS22382.1
    UniProtKB/Swiss-Prot
    Q3UV59, Q60837
    Related
    ENSMUSP00000000808.8, ENSMUST00000000808.8
    Conserved Domains (2) summary
    pfam00041
    Location:470553
    fn3; Fibronectin type III domain
    pfam02720
    Location:657714
    DUF222; Domain of unknown function (DUF222)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    71261005..71276186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509557.4XP_006509620.1  interleukin-12 receptor subunit beta-1 isoform X1

    Conserved Domains (2) summary
    pfam00041
    Location:470553
    fn3; Fibronectin type III domain
    pfam02720
    Location:658715
    DUF222; Domain of unknown function (DUF222)
  2. XM_006509559.5XP_006509622.1  interleukin-12 receptor subunit beta-1 isoform X3

    Conserved Domains (1) summary
    pfam00041
    Location:470553
    fn3; Fibronectin type III domain
  3. XM_006509560.5XP_006509623.1  interleukin-12 receptor subunit beta-1 isoform X4

    UniProtKB/TrEMBL
    A0A1D5RL98
    Related
    ENSMUSP00000148279.2, ENSMUST00000212657.2
    Conserved Domains (1) summary
    pfam00041
    Location:470552
    fn3; Fibronectin type III domain
  4. XM_006509558.5XP_006509621.1  interleukin-12 receptor subunit beta-1 isoform X2

    Conserved Domains (2) summary
    pfam00041
    Location:449532
    fn3; Fibronectin type III domain
    pfam02720
    Location:637694
    DUF222; Domain of unknown function (DUF222)
  5. XM_006509561.5XP_006509624.1  interleukin-12 receptor subunit beta-1 isoform X5

    See identical proteins and their annotated locations for XP_006509624.1

    Conserved Domains (1) summary
    pfam00041
    Location:305388
    fn3; Fibronectin type III domain
  6. XM_011242266.4XP_011240568.1  interleukin-12 receptor subunit beta-1 isoform X5

    See identical proteins and their annotated locations for XP_011240568.1

    Conserved Domains (1) summary
    pfam00041
    Location:305388
    fn3; Fibronectin type III domain
  7. XM_006509562.4XP_006509625.1  interleukin-12 receptor subunit beta-1 isoform X6

    Conserved Domains (1) summary
    pfam00041
    Location:191274
    fn3; Fibronectin type III domain