Il1b interleukin 1 beta [ Mus musculus (house mouse) ]

Gene ID: 16176, updated on 12-Mar-2024

Summary

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Official Symbol: Il1bprovided by MGI
Official Full Name: interleukin 1 betaprovided by MGI
Primary source: MGI:MGI:96543
See related: Ensembl:ENSMUSG00000027398 AllianceGenome:MGI:96543
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Il-1b; IL-1beta
Summary: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1. The encoded protein plays a role in thymocyte proliferation and is involved in the inflammatory response. [provided by RefSeq, Aug 2015]
Expression: Broad expression in spleen adult (RPKM 1.3), lung adult (RPKM 1.0) and 19 other tissues See more
Orthologs: human all
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Genomic context

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See Il1b in Genome Data Viewer

Location:: 2 F1; 2 62.97 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (129206490..129213059, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (129364569..129371164, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-1beta promotes MPN disease initiation by favoring early clonal expansion of JAK2-mutant hematopoietic stem cells.
Title: IL-1β promotes MPN disease initiation by favoring early clonal expansion of JAK2-mutant hematopoietic stem cells.
Serine synthesis sustains macrophage IL-1beta production via NAD[+]-dependent protein acetylation.
Title: Serine synthesis sustains macrophage IL-1β production via NAD(+)-dependent protein acetylation.
NLRP3-GSDMD-dependent IL-1beta Secretion from Microglia Mediates Learning and Memory Impairment in a Chronic Intermittent Hypoxia-induced Mouse Model.
Title: NLRP3-GSDMD-dependent IL-1β Secretion from Microglia Mediates Learning and Memory Impairment in a Chronic Intermittent Hypoxia-induced Mouse Model.
Salmonella manipulates the host to drive pathogenicity via induction of interleukin 1beta.
Title: Salmonella manipulates the host to drive pathogenicity via induction of interleukin 1β.
Severe inflammation in C57/BL6 mice leads to prolonged cognitive impairment by initiating the IL-1beta/TRPM2 pathway.
Title: Severe inflammation in C57/BL6 mice leads to prolonged cognitive impairment by initiating the IL-1β/TRPM2 pathway.
Transcriptome analysis of the cerebral cortex of acrylamide-exposed wild-type and IL-1beta-knockout mice.
Title: Transcriptome analysis of the cerebral cortex of acrylamide-exposed wild-type and IL-1β-knockout mice.
Inhibiting mtDNA-STING-NLRP3/IL-1beta axis-mediated neutrophil infiltration protects neurons in Alzheimer's disease.
Title: Inhibiting mtDNA-STING-NLRP3/IL-1β axis-mediated neutrophil infiltration protects neurons in Alzheimer's disease.
Tmem178 Negatively Regulates IL-1beta Production Through Inhibition of the NLRP3 Inflammasome.
Title: Tmem178 Negatively Regulates IL-1β Production Through Inhibition of the NLRP3 Inflammasome.
Myeloid Cell Derived IL1beta Contributes to Pulmonary Hypertension in HFpEF.
Title: Myeloid Cell Derived IL1β Contributes to Pulmonary Hypertension in HFpEF.
ICAM-1 Abundance Is Increased in Pancreatic Islets of Hyperglycemic Female NOD Mice and Is Rapidly Upregulated by NF-kappaB in Pancreatic beta-Cells.
Title: ICAM-1 Abundance Is Increased in Pancreatic Islets of Hyperglycemic Female NOD Mice and Is Rapidly Upregulated by NF-κB in Pancreatic β-Cells.

Submit: New GeneRIF Correction See all GeneRIFs (806)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Il1b (e-PCR), detects polymorphism
- UniSTS:257045

PMC22755P1 (e-PCR)
- UniSTS:272152

PMC151130P1 (e-PCR)
- UniSTS:271139

Il1b (e-PCR), detects polymorphism
- UniSTS:259396

X04964 (e-PCR)
- UniSTS:125786

Il1b (e-PCR), detects polymorphism
- UniSTS:256683

Il1b (e-PCR), detects polymorphism
- UniSTS:143541

NoName (e-PCR)
- UniSTS:143542

Il1b (e-PCR), detects polymorphism
- UniSTS:143543

D2Mit135 (e-PCR), detects polymorphism
- UniSTS:128995

M15131 (e-PCR)
- UniSTS:124919

D2Nds3 (e-PCR), detects polymorphism
- UniSTS:142333

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables interleukin-1 receptor binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor ligand activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within astrocyte activation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to interleukin-17	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to organic substance	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ectopic germ cell programmed cell death	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fever generation	IEA Inferred from Electronic Annotation more info
involved_in hyaluronan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within interleukin-1 beta production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in interleukin-1-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within leukocyte migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within macrophage cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in monocyte aggregation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of adiponectin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of branching morphogenesis of a nerve	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gap junction assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glucose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of glutamate secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neutrophil chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of RNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 1 cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of astrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcidiol 1-monooxygenase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of chemokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of complement activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fever generation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of granulocyte macrophage colony-stimulating factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immature T cell proliferation in thymus	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of immature T cell proliferation in thymus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte chemotactic protein-1 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myosin light chain kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of p38MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of prostaglandin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info
involved_in regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of defense response to virus by host	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of nitric-oxide synthase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of nitric-oxide synthase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of nitric-oxide synthase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to ATP	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to ATP	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to carbohydrate	IDA Inferred from Direct Assay more info	PubMed
involved_in response to interleukin-1	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in sequestering of triglyceride	ISO Inferred from Sequence Orthology more info
involved_in social behavior	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: interleukin-1 beta

Names: IL-1 beta; interleukin 1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008361.4 → NP_032387.1 interleukin-1 beta

See identical proteins and their annotated locations for NP_032387.1

Status: REVIEWED

Source sequence(s)

AK225002

Consensus CDS

CCDS16726.1

UniProtKB/Swiss-Prot

P10749, Q2M4J6

Related

ENSMUSP00000028881.8, ENSMUST00000028881.14

Conserved Domains (2) summary

smart00125
Location:120 → 265

IL1; Interleukin-1 homologues

pfam02394
Location:1 → 101

IL1_propep; Interleukin-1 propeptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

129206490..129213059 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006498795.5 → XP_006498858.1 interleukin-1 beta isoform X1

Conserved Domains (2) summary

smart00125
Location:126 → 271

IL1; Interleukin-1 homologues

pfam02394
Location:21 → 107

IL1_propep; Interleukin-1 propeptide