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Il1r2 interleukin 1 receptor, type II [ Mus musculus (house mouse) ]

Gene ID: 16178, updated on 17-Mar-2024

Summary

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Official Symbol
Il1r2provided by MGI
Official Full Name
interleukin 1 receptor, type IIprovided by MGI
Primary source
MGI:MGI:96546
See related
Ensembl:ENSMUSG00000026073 AllianceGenome:MGI:96546
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD121b; Il1r-2
Summary
Enables interleukin-1 binding activity and interleukin-1 receptor activity. Acts upstream of or within negative regulation of gene expression and negative regulation of interleukin-1-mediated signaling pathway. Located in cytoplasm. Is expressed in several structures, including dorsal aorta; gut; pituitary gland; reproductive system; and thymus. Human ortholog(s) of this gene implicated in aggressive periodontitis. Orthologous to human IL1R2 (interleukin 1 receptor type 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 4.5), mammary gland adult (RPKM 1.6) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 B; 1 18.65 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (40123872..40164390)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (40084692..40125230)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00730 Neighboring gene predicted gene, 35600 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:39952403-39952658 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:39953411-39953598 Neighboring gene STARR-seq mESC enhancer starr_00731 Neighboring gene STARR-seq mESC enhancer starr_00732 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:39991996-39992105 Neighboring gene STARR-positive B cell enhancer ABC_E9463 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 4 Neighboring gene VISTA enhancer mm1333 Neighboring gene STARR-positive B cell enhancer mm9_chr1:40142581-40142881 Neighboring gene STARR-seq mESC enhancer starr_00736 Neighboring gene predicted gene, 16894 Neighboring gene predicted gene, 35741 Neighboring gene STARR-positive B cell enhancer ABC_E5749 Neighboring gene interleukin 1 receptor, type I Neighboring gene STARR-seq mESC enhancer starr_00738

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. IL-1R signaling promotes STAT3 and NF-κB factor recruitment to distal cis-regulatory elements that regulate Il17a/f transcription. Whitley SK, et al. J Biol Chem, 2018 Oct 12. PMID 30093408, Free PMC Article
  2. Differential expression of interleukin 1 receptor type II during mouse decidualization. Zhang XH, et al. Reprod Sci, 2012 Sep. PMID 22556012
  3. Transcription factor Zbtb38 downregulates the expression of anti-inflammatory IL1r2 in mouse model of rheumatoid arthritis. Ocskó T, et al. Biochim Biophys Acta Gene Regul Mech, 2018 Nov. PMID 30343694
  4. IL-1R2 deficiency suppresses dextran sodium sulfate-induced colitis in mice via regulation of microbiota. Yoshida K, et al. Biochem Biophys Res Commun, 2018 Feb 12. PMID 29366788
  5. Deficiency in IL-1 Receptor Type 2 Aggravates K/BxN Serum Transfer-Induced Arthritis in Mice but Has No Impact on Systemic Inflammatory Responses. Martin P, et al. J Immunol, 2017 Apr 1. PMID 28235865

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of T follicular regulatory cell-derived IL-1R2 augments germinal center reactions via increased IL-1.
    Title: Loss of T follicular regulatory cell-derived IL-1R2 augments germinal center reactions via increased IL-1.
  2. IL1R2 promotes retinal angiogenesis to participate in retinopathy of prematurity by activating the HIF1alpha/PFKFB3 pathway.
    Title: IL1R2 promotes retinal angiogenesis to participate in retinopathy of prematurity by activating the HIF1α/PFKFB3 pathway.
  3. Decreased Expression of EZH2 in Granulosa Cells Contributes to Endometriosis-Associated Infertility by Targeting IL-1R2.
    Title: Decreased Expression of EZH2 in Granulosa Cells Contributes to Endometriosis-Associated Infertility by Targeting IL-1R2.
  4. Cardiomyocyte IL-1R2 protects heart from ischemia/reperfusion injury by attenuating IL-17RA-mediated cardiomyocyte apoptosis.
    Title: Cardiomyocyte IL-1R2 protects heart from ischemia/reperfusion injury by attenuating IL-17RA-mediated cardiomyocyte apoptosis.
  5. Our studies demonstrate that Zbtb38 forms a molecular bridge between an arthritis-associated epimutation (DNA hypomethylation in Zbtb38 promoter) and transcriptional silencing of the IL1r2 gene in B cells. In this way, disease-associated DNA hypomethylation can support autoimmune arthritis by interfering with an anti-inflammatory pathway.
    Title: Transcription factor Zbtb38 downregulates the expression of anti-inflammatory IL1r2 in mouse model of rheumatoid arthritis.
  6. Il1r2 encourages STAT3 to bind to cis-elements that regulate expression of interleukin-17.
    Title: IL-1R signaling promotes STAT3 and NF-κB factor recruitment to distal cis-regulatory elements that regulate Il17a/f transcription.
  7. Thus, we show that IL-1R2 is harmful for the development of colitis, because IL-1R2 promotes the growth of proinflammatory intestinal microbiota by suppressing IL-1beta-induced AMP production.
    Title: IL-1R2 deficiency suppresses dextran sodium sulfate-induced colitis in mice via regulation of microbiota.
  8. present study demonstrated the ability of Staphylococcus aureus to induce IL-1RII shedding in myeloid cells
    Title: Staphylococcus aureus Induces Shedding of IL-1RII in Monocytes and Neutrophils.
  9. Our data demonstrate that the decoy receptor IL-1R2 plays an important inhibitory role in local IL-1- and neutrophil-dependent tissue inflammation
    Title: Deficiency in IL-1 Receptor Type 2 Aggravates K/BxN Serum Transfer-Induced Arthritis in Mice but Has No Impact on Systemic Inflammatory Responses.
  10. Data indicate that a disintegrin and metallopeptidase domain 17 (ADAM17) regulates interleukin (IL)-1 signaling via cleavage of IL-1 receptor type 2 (IL-1R2).
    Title: ADAM17 regulates IL-1 signaling by selectively releasing IL-1 receptor type 2 from the cell surface.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables interleukin-1 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-1 binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables interleukin-1 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-1 receptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables interleukin-1, type II, blocking receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of cytokine production involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of interleukin-1 alpha production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of interleukin-1-mediated signaling pathway IPI
Inferred from Physical Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of protein processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of protein processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
interleukin-1 receptor type 2
Names
CD121 antigen-like family member B
IL-1 receptor beta chain
IL-1 type II receptor
IL-1R-2
IL-1R-beta
IL-1RT-2
IL-1RT2
interleukin-1 receptor beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360800.1 → NP_001347729.1  interleukin-1 receptor type 2 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC161534
    Conserved Domains (1) summary
    PHA02785
    Location:54 → 382
    PHA02785; IL-beta-binding protein; Provisional

  2. NM_001360801.1 → NP_001347730.1  interleukin-1 receptor type 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC161534, BC032962
    UniProtKB/TrEMBL
    Q8K084
    Conserved Domains (2) summary
    PHA02785
    Location:1 → 234
    PHA02785; IL-beta-binding protein; Provisional
    cl11960
    Location:18 → 112
    Ig; Immunoglobulin domain

  3. NM_010555.5 → NP_034685.1  interleukin-1 receptor type 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_034685.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC161534, AK132264
    Consensus CDS
    CCDS14909.1
    UniProtKB/Swiss-Prot
    P27931
    UniProtKB/TrEMBL
    Q4FK69
    Related
    ENSMUSP00000027243.8, ENSMUST00000027243.13
    Conserved Domains (1) summary
    PHA02785
    Location:36 → 364
    PHA02785; IL-beta-binding protein; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    40123872..40164390
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317722.3 → XP_017173211.1  interleukin-1 receptor type 2 isoform X1

    Conserved Domains (1) summary
    PHA02785
    Location:54 → 382
    PHA02785; IL-beta-binding protein; Provisional

  2. XM_011238437.4 → XP_011236739.1  interleukin-1 receptor type 2 isoform X2

    See identical proteins and their annotated locations for XP_011236739.1

    UniProtKB/Swiss-Prot
    P27931
    UniProtKB/TrEMBL
    Q4FK69
    Conserved Domains (1) summary
    PHA02785
    Location:36 → 364
    PHA02785; IL-beta-binding protein; Provisional

  3. XM_030250758.2 → XP_030106618.1  interleukin-1 receptor type 2 isoform X2

    UniProtKB/Swiss-Prot
    P27931
    UniProtKB/TrEMBL
    Q4FK69
    Conserved Domains (1) summary
    PHA02785
    Location:36 → 364
    PHA02785; IL-beta-binding protein; Provisional

  4. XM_011238438.3 → XP_011236740.1  interleukin-1 receptor type 2 isoform X2

    See identical proteins and their annotated locations for XP_011236740.1

    UniProtKB/Swiss-Prot
    P27931
    UniProtKB/TrEMBL
    Q4FK69
    Conserved Domains (1) summary
    PHA02785
    Location:36 → 364
    PHA02785; IL-beta-binding protein; Provisional

  5. XM_011238440.4 → XP_011236742.1  interleukin-1 receptor type 2 isoform X2

    See identical proteins and their annotated locations for XP_011236742.1

    UniProtKB/Swiss-Prot
    P27931
    UniProtKB/TrEMBL
    Q4FK69
    Conserved Domains (1) summary
    PHA02785
    Location:36 → 364
    PHA02785; IL-beta-binding protein; Provisional

  6. XM_036162222.1 → XP_036018115.1  interleukin-1 receptor type 2 isoform X2

    UniProtKB/Swiss-Prot
    P27931
    UniProtKB/TrEMBL
    Q4FK69
    Conserved Domains (1) summary
    PHA02785
    Location:36 → 364
    PHA02785; IL-beta-binding protein; Provisional

  7. XM_006495726.4 → XP_006495789.1  interleukin-1 receptor type 2 isoform X3

    UniProtKB/TrEMBL
    Q8K084
    Conserved Domains (2) summary
    PHA02785
    Location:1 → 234
    PHA02785; IL-beta-binding protein; Provisional
    cl11960
    Location:18 → 112
    Ig; Immunoglobulin domain

RNA

  1. XR_003952769.2 RNA Sequence

  2. XR_003952762.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27931.1 GenPept UniProtKB/Swiss-Prot:P27931

Gene LinkOut

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