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Il2rg interleukin 2 receptor, gamma chain [ Mus musculus (house mouse) ]

Gene ID: 16186, updated on 3-Aug-2021

Summary

Official Symbol
Il2rgprovided by MGI
Official Full Name
interleukin 2 receptor, gamma chainprovided by MGI
Primary source
MGI:MGI:96551
See related
Ensembl:ENSMUSG00000031304
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
gc; p64; [g]c; gamm; CD132; gamma(; gamma(c)
Summary
This gene encodes a transmembrane protein that is a common subunit of several interleukin receptor complexes. These receptors are comprised of alpha and beta subunits in addition to this gamma subunit. Signalling through this pathway in important in immune cell differentiation and function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
Expression
Biased expression in thymus adult (RPKM 107.8), spleen adult (RPKM 68.6) and 5 other tissues See more
Orthologs
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Genomic context

See Il2rg in Genome Data Viewer
Location:
X D; X 43.9 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (100307991..100311861, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (101264385..101268255, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (98459726..98463545, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene forkhead box O4 Neighboring gene predicted gene 614 Neighboring gene mediator complex subunit 12 Neighboring gene neuroligin 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables interleukin-15 receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-2 binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cytokine receptor common subunit gamma
Names
IL-2 receptor subunit gamma
IL-2R subunit gamma
common gamma chain
gamma C receptor
interleukin-2 receptor subunit gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308535.1NP_001295464.1  cytokine receptor common subunit gamma isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) uses an alternate splice site, which results in a frameshift, compared to variant a. The encoded isoform (b) is shorter than isoform a and has a distinct C-terminus.
    Source sequence(s)
    AK143669, AL683892, KC815469
    UniProtKB/TrEMBL
    Q3UPA9, V5SIM2
    Conserved Domains (2) summary
    cd00063
    Location:154218
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:59151
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. NM_013563.4NP_038591.1  cytokine receptor common subunit gamma isoform a precursor

    See identical proteins and their annotated locations for NP_038591.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK143669, AL683892
    Consensus CDS
    CCDS30312.1
    UniProtKB/Swiss-Prot
    P34902
    UniProtKB/TrEMBL
    Q3UPA9
    Related
    ENSMUSP00000033664.8, ENSMUST00000033664.14
    Conserved Domains (2) summary
    cd00063
    Location:154247
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:59151
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    100307991..100311861 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318396.3XP_017173885.1  cytokine receptor common subunit gamma isoform X1

    Conserved Domains (2) summary
    cd00063
    Location:181274
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:86158
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
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