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Impact impact, RWD domain protein [ Mus musculus (house mouse) ]

Gene ID: 16210, updated on 23-Jun-2021

Summary

Official Symbol
Impactprovided by MGI
Official Full Name
impact, RWD domain proteinprovided by MGI
Primary source
MGI:MGI:1098233
See related
Ensembl:ENSMUSG00000024423
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E430016J11Rik
Expression
Broad expression in frontal lobe adult (RPKM 16.8), cerebellum adult (RPKM 14.5) and 23 other tissues See more
Orthologs
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Genomic context

See Impact in Genome Data Viewer
Location:
18; 18 A1
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (13087747..13126007)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (12954690..12992950)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (13130761..13151457)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 1A Neighboring gene predicted gene, 36439 Neighboring gene ribosomal protein S8 pseudogene Neighboring gene histamine receptor H4 Neighboring gene ribosomal protein SA pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in GCN2-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to UV-C IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to acidic pH IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to amino acid starvation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to benomyl IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to glucose starvation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to leucine starvation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell death IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription from RNA polymerase II promoter in response to stress IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of translational initiation in response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of polysome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein IMPACT
Names
imprinted and ancient gene protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357396.1NP_001344325.1  protein IMPACT isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC131672, BM899561
    Conserved Domains (2) summary
    smart00591
    Location:197
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    pfam01205
    Location:164270
    UPF0029; Uncharacterized protein family UPF0029
  2. NM_008378.3NP_032404.1  protein IMPACT isoform 1

    See identical proteins and their annotated locations for NP_032404.1

    Status: VALIDATED

    Source sequence(s)
    AC131672, AK138136, BM899561, CJ056911
    Consensus CDS
    CCDS29068.1
    UniProtKB/Swiss-Prot
    O55091
    Related
    ENSMUSP00000025290.6, ENSMUST00000025290.7
    Conserved Domains (2) summary
    smart00591
    Location:15115
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    pfam01205
    Location:181288
    UPF0029; Uncharacterized protein family UPF0029

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    13087747..13126007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246850.3XP_011245152.1  protein IMPACT isoform X1

    See identical proteins and their annotated locations for XP_011245152.1

    Conserved Domains (2) summary
    smart00591
    Location:197
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    pfam01205
    Location:164270
    UPF0029; Uncharacterized protein family UPF0029

RNA

  1. XR_001782344.3 RNA Sequence

  2. XR_004939837.1 RNA Sequence

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